wk 13, lec 3 Flashcards

1
Q

mammary gland is what type of gland

A

Modified sudiferous (sweat) glands

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2
Q

milk is made in

A

terminal duct lobular unit (TDLU)

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3
Q

where does milk go from and to

A

Milk is made in the terminal duct lobular unit (TDLU) which
consists of smaller lobules and terminal ducts→drain into a
lactiferous duct → lactiferous sinus → collecting ducts →
open to the nipple

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4
Q

milk secretion vs milk ejection

A

suckling and mechanoreceptors to hypothalamus

milk ejection: from oxytocin in posterior pituitary

milk secretion: from prolactin in anterior pituitary

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5
Q

areola

A

pigment skin around nipple; pigment increases with pregnancy

lacks hair and sweat glands

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6
Q

what glands are in areola and what do they secrete

A

Contains areolar glands AKA Glands of
Montgomery

secrete oily substance to lubricate areola and nipple, also olfactory so babies can smell

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7
Q

function of Montgomery glands/tubercles on the areola

A
  • Lubrication and Protection
  • Antimicrobial Properties
  • Neonatal Olfactory Cue
  • Hormonal Influence
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8
Q

lymphatics in breast

A

axillary or lateral pathway get 75% of lymph from boobs

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9
Q

suspensory ligament in breast for shape

A

coopers ligaments

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10
Q

changes during menstrual cycle in the terminal duct lobular unit TDLU

A

follicular phase: fewer terminal ducts, ..

literal phase: myoepithelial cells more prominent; causes fullness and tenderness

menses: return to follicular state

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11
Q

tanner stages of breast development

A

stage 1: prepubertal; elevation of nipple

stage 2 (begin puberty): breast bud stage, elevation of breast and nipple as small mound, enlarge areolar diameter

stage 3 (11-13yoa): further enlargement and elevation of breast and areola, no separation of contours

stage 4 (13-15yoa): projection of areola and nipple to form secondary mound above the level of the breast

stage 5 (15+ yoa): mature; projection of nipple only, areola has receded to general contour of breast

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12
Q

breast in pregnancy

A

increase nipple and areola pigmentation

TDLU grows, increase stoma vascularity

more secretions from lobular epithelial cells for lactation

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13
Q

breast in menopause

A

TDLU atrophy

increase adipose > fibrous tissue

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14
Q

acute mastitis

A

from breastfeeding

nipple cracks let strept and staph (bacteria) enter

blocked milk discharge

sx: pain, edema, erythema, fever, malaise, unilateral

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15
Q

periductal mastitis

A

unrelated to pregnancy

squamous metaplasia of ducts –> keratin plugs, duct obstruction, bacterial infection

cigarettes!!!

sx: painful sub-areolar mass, keratin plugs, inflammed, fistula

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16
Q

granulomatous mastitis

A

granulomas

from infection (mycobacteria, parasite, fungi) or autoimmune or breast implant

sx: large tender lump, granuloma, seems like malignancy, erythema, ulceration

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17
Q

ductal ectasia of breast

A

peri/post menopause, previous trauma and blocks of ducts, smoking, obesity

ductal dilation and periductal inflammation

fibrosis of ducts; fibrosis can obliterate ducts

thick secretions; debris, foamy macrophage

ducts rupture and cause granulomas

sx: serous or bloody discharge, mass, pain, nipple retraction (from duct wall fibrosis)

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18
Q

nipple retraction and in menopause in which breast condition

A

duct ectasia

19
Q

fat necrosis of the breast

A

necrotic fat cells

hemorrhage –> foamy macrophage and lipid droplets –> fibrosis and calcification

history of trauma to area

hard mass, skin tethering (retraction or dimpling of skin over breast; mimic carcinoma)

20
Q

which breast pathoglogy has skin tethering which mimics carcinoma (retraction or dimpling of skin over breast)

usually from trauma

A

fat necrosis

21
Q

fibrocystic breasts (benign)

A

gross and microscopic cysts

apocrine metaplasia

fibrous stoma

from homronal fluctuations (estrogen and progesterone) in ages 20-50 typically

asymptomatic, nodules, pain, swelling, nipple discharge is cyst rupture

**cyclical- worse in luteal phase (bc hormones)

22
Q

firboademona (bening- breast)

A

stromal and epithelial elements

not malignnat

hormonal cause (but dont change throuhgh menstural cycle like fibrocystic breast do); grow in prengnacy

silent, painless, calcified, bilateral

23
Q

malignant; great carcinoma

A

90% sporadic, 10% familial

stimulated by estrogen (risks; early monarche, late menopause, old first pregnancy), radiation, alcohol, obese, smoking

decrease with anti-estrogen therapy

24
Q

genes for familial breast carcinoma

A

BRCA1 and BRCA2

tumor suppressor genes which are autosomal dominant (also for ovarian cancer, pancreatic, prostate…)

Majority of cancer will be ER/PR/HER2 negative, and often
involves p53 mutations

BRCA2 are often ER (estrogen receptor) positive and less aggressive than BRCA1

25
Q

breast carcinoma in situ

A

in situ: ductal carcinoma in situ (DCIS) involves the ducts or if
affects the lobules is called lobular carcinoma in situ
(LCIS)

mostly in upper outer quadrant

26
Q

invasive ductal carcinoma (breast)

A

ER and PR (estrogen and progesterone receptor positive, some HER2 positive)

dense masses on mammography

DCIS in 80%

27
Q

invasive lobular carcinoma

A

patients often have clinically silent disease
grossly and by mammography

more are ER positive than ductal

e-cadherin absent

spread to the peritoneum, retroperitoneum, ovary
and uterus, leptomeninges, and gastrointestinal tract

28
Q

invasive lobular vs ductal carcinaom

A

lobular: grossly and mammography silent
ductal: masses found easily

29
Q

Paget disease of the nipple (malignant)

A

rare; glandular in nipple (erythema, edema, retraction)

Associated with underlying DCIS, with or without invasive ductal carcinoma

30
Q

3 botanical actions for cramps

A

antispasmodic
analgesic
hepatic

31
Q

why do an antispasmodic in cramps

A

reduce muscle spasms and smooth muscle tension, help with any digestive spasms, help calm the nervous system and relax the smooth muscle in the blood vessels

32
Q

why do an analgesic in cramps

A

help with pain and discomfrot. help with menstural cramps, help with discomfort and muscle aches

33
Q

why do a hepatic in cramps

A

liver for hormone metabolism and detoxification. can help clear excess hormones (estrogen) which can effect cramps and menses. Helps with any hormonal imbalances that worsen sx. help to metabolize estrogen. help with associated sx of an overburdened liver ie bloating, discomfort, fatigue

34
Q

4 herbs and % for cramps

A

cramp-bark 30%
jamaican dogwood 30%
wild yam 30%
california poppy 10%

35
Q

why choose cramp-bark for cramps

A

antispasmodic, anti-inflammatory. Helps relax smooth muscle to help with cramps or GI pain. calming effect on nervous system to relief stress and anxiety. helps regulate blood flow and relieve tension

36
Q

why chose jamaican dog wood for crmaps

A

antispasmodic, analgesic, sedative. Helps relax muscles, relieve pain, calm nervous system.

37
Q

why choose California poppy for cramps

A

antispasmodic, analgesic, sedative. good to help with uterine muscle contractions, muscle pain . sedative to calm nervous system, stress, anxiety. help improve sleep, which can be disrupted by cramps

38
Q

why choose wild yam for cramps

A

hepatic, antispasmodic, anti-inflammatory. a “female herb” (progesterone precurosr in vitro). phytoestrogens which can help with hormonal imbalances causing cramps. relax muscles to help cramps and low back and ab. support uterine health via relax uterus muscles and promote blood flow to the area. help normalize cycles. reduce inflammation

39
Q

dose and duration for cramp prescription

A

tincture 1-2tbsp; acutely as needed

40
Q

contraindications for cramp formula

A

all safe- dont use in pregnacy but wouldnt be the case

some sedatives but should be ok (i.e. driving, heavy machinery)

41
Q

2 other recommendations for cramps

A
  1. moderate intensity cardiovascular exercise and yoga 2-5x/wk
  2. diet: anti inflmmatory (omega 3, tumeric, ginger, berries), and magenisum rich foods, avoid inflammatory and refined foods, food rich in iron
42
Q

why do exercise and yoga for cramps

A

cardio to relieve cramps via increasing blood to pelvic area and promote relaxation (i.e. walk, swim, cycle). yoga for calming, relaxation, control breathing

43
Q

why do anti inflammatory diet and avoid processed, eat iron for cramps

A

anti inflam (omegas, tumeric, ginger) to reduec infalmmation. Mg rich to relax muscles (i.e. nuts, seeds, leafy vegetables), avoid sugar, caffeien, processed. have high iron to restore blood loss