Wk 1 High yield material

Question 1

PK variabilities

Answer 1

PK-M1: most tissues

PK-M2: embryonic tissue (lower activity)

PK-L: Liver

PK-R: Red blood cells

Question 2

NADH/NADPH precursor

Answer 2

Niacin (Vitamin B₃)

also synthesized from Typ, but not sufficient for needs

Question 3

Disease of niacin deficincy

Answer 3

Pallegra

DDD

Diarrhea, dermatitis, dementia

+

glossitis

Question 4

FADH₂ precursor

Answer 4

riboflavin (vitamin B₂)

milk, eggs, organ meats, legumes, mushrooms

Question 5

Riboflavin (Vit B₂) deficiency

Answer 5

cheilosis

glossitis

Question 6

Functions of vitamin C

Answer 6

Cofactor for hydroxylases (proline–>hydroxyproline)

Neurotransmitter synthesis

Oxygen sensing

Nonenzymatic antioxidant