W4 Protein Synthesis Inhibitors

Question 1

Oxazolidinones

• Mechanism*
• Spec*
• Resistance*
• Adverse*

Answer 1

• Linezolid
• bacteriostatic– + incl. MRSA, vanco resistant Enterococci
• 23S alterations
• bone marrow suppression, serotonin syndrome

Question 2

Aminoglycosides

Tobramycin, Gentamicin, Amikacin

• Mechanism*
• Spec*
• Resistance*
• Adverse*

Answer 2

• prevent initial complex formation
• (-) aerobic
• cell wall/drug alteration
• nephrotoxicity, ototoxicity, XXX PREGNANCY

Question 3

Tetracyclines

Tetracycline, Doxycycline, Minocycline

• Mechanism*
• Spec*
• Resistance*
• Adverse*

Answer 3

• X attachment of tRNA onto 30S
• M. pneumonia, H. phlori (Lyme disease)
• increased efflux
• side effects:
  
  • chelates: bad absorption
  • photosensitivity
  • bad teeth/bone growth
  • XXX PREGNANCY

Question 4

Chloramphenicols

Chloramphenicol

• Mechanism*
• Spec*
• Resistance*
• Adverse*

Answer 4

• X peptide bond formation, 50S
• extended
• drug aceylation
• bone marrow suppression, aplastic anemia

Question 5

Macrolides

Erythromycin, Azithromycin, Clarithromycin

• Mechanism*
• Spec*
• Resistance*
• Adverse*

Answer 5

• X translocation, 50S
• chlamydia, upper respiratory tract
• binding site mod, inc. efflux
• Cyt P450 inhibitor
  
  • CLARITHROMYCIN XXX PREGNANCY

Question 6

Lincosamide

Clindamycin

• Mechanism*
• Spec*
• Resistance*
• Adverse*

Answer 6

• X translocation, 50S
• • aerobic, acne
• binding site change, drug alteration
• C. diff superinfection

Question 7

Streptogrammins

Quinupristin, Dalfopristin

• Mechanism*
• Spec*
• Resistance*
• Adverse*

Answer 7

• X translocation
• multidrug resistant G+ bacteria
• drug site modification, more efflux
• Cyt P450 inhibitor