W3-3Nucleotides

Question 1

Gout pathology

Answer 1

Xanthine oxidase overactivity: purine metabolism Treated with XO inhibitor allopurinal Uric acid precipitates in distal parts of body due to decreased body temperature

Question 2

Combined immunodeficiency

Answer 2

Purine nucleoside phosphorylase deficiency

Symptoms: low T-cells, chronic infections, failure to thrive, neurologic symptoms

Question 3

Severe combined immunodefiency

Answer 3

Adenosine deaminase deficiency (elevated 2-deoxyadenosine)

Severe suceptibility to infections

Lymphocytes < 500, costrochondral junction dysplasia

Question 4

Lensch-Nyhan Disease

Answer 4

Hypoxanthine-guanine phosphoribosyltransferase deficiency

X-linked, characterized by self mutalation, neurological symptoms

He’s

Got

Purine

Recycling

Trouble

Question 5

These nucleotides are build directly onto the ribose sugar

Answer 5

purines

Question 6

These nucleotides are first built then joined with the sugar

Answer 6

pyrimidines

Question 7

This nucleotide group has several metobolic diseases

Answer 7

purines

Question 8

Sugar used for nucleotide synthesis

Answer 8

phosphoribosyl-1-pyrophosphate

(PRPP)

Question 9

This amino acid donates the first amine group for purine synthesis onto PRPP

Answer 9

glutamine

Question 10

Nucleotides are reduced (for DNA) at which level of phosphorylation

Answer 10

diphosphorylation

Question 11

This enzyme is responsible for reducing the sugar component of nucleotides

Answer 11

ribonucleotide reductase

Question 12

Ribonucleotide reductase uses this cofactor

Answer 12

thioredoxin

Question 13

What is the primary cause of gout?

Answer 13

diet, especially one high in liver and organ meats

exacerbations may occur use to cold