WEEK 4- Fibro pt 2 Flashcards
anterolateral system carries what type of info
pain temp
crude touch pressure
lateral spino carries what modality
pain temp
pain and temp are carries in what type of axons
a delta
c
true or false c fibers are faster than a delta
false, c is unmyelenated
‘An unpleasant sensory and emotional experience associated with actual or potential tissue damage, or described in terms of such damage’. described what
PAIN
is pain subjective
yes
true or false, pain is only expressed by sensory feelings
FALSE
whole bunch of networks
pain and temperature are sensed by what type of cutaneous receptor
free nerve endings
what general category of receptors does pain get felt by
NOCICEPTORS
true or false nociceptors have large diamter axons
false
true or false all nociceptors are myelnated
false, c fibers are not
true or false nocicpetors conduct fact signals
FALSE
which provides more localized location for stimulus touch or pain
touch
Transient receptor potential (TRP) can sense what kind of stimuli
reacts to heat and capsacian
what is capsacian
pepper = hot
what is a TRP
specific receptor on the periphery that senses heat and capsacian
does trp only sense heat
no capsacian also
true or false there exisst Specific receptors for a variety of stimuli
true
chemical, thermal, or mechanical - under
which fibers do we find the receptors in
a delta
c
true or false at rest the pore of teh receptor in the neuron for pain is closed
true
true or false we have different trp channels
true
where are trp channels located
DRG
true or false TRP are Ion channels located on the plasma membrane
true
what do TRP receptors mediate
pain, hotness, warmth or coldness, different kinds of tastes, and pressure.
for example if we have a trp receptor for temperature , would above 45 degrees be considered painful?
yes = starts to be detected as nociceptiron
Thermal (Aδ-I fibers) –
extreme temperature > 45°C or < 17°C
Mechanical (Aδ-II fibers)
– intense pressure applied to the skin
Polymodal (C-fibers) –
high-intensity mechanical, thermal or chemical
what can create pain
capsasium cream
extremely cold water
needles
Thermoreceptive afferents :
discharge with non-painful and non- damaging warming of the skin
n Nociceptors only begin to discharge
with skin temperatures that cause tissue damage
true or false nociceptors can sense pain at higher temperatures
true
do thermoreceptors discriminate between painful temperature and normal temperature
yes1
how many nociceptor mechanisms do we have (fibers)
2
sharp initial pain is asscoiated with what fiber
a delta
dull long lasting second pain is associate dwith which fiber
c
what othe rmodalities besides pain and temp doe sthe anterolasteral system account for
n Non-discriminative touch (in the absence of dorsal columns) n Innocuous warm & cold temperature sensations
n Histamine – hitch
n Slow mechanical sensation – sensual touch
n Sensors of lactic acid released during muscle contraction
c fibers synapse have input in what layers of dorsal horn
1 and 2
a delta fibers have input in what layers of dorsal horn
1 and 5
true or false Neurons in layer V receive ONLY nociceptive inpiuts
false
non nociceptive also
where do 2nd neurons cross teh midline
AWC
what is referred pain
Pain perceived at a location other than the site of the painful stimulus
what is the theory that helps explain referred pain
Convergence of nociceptors onto the same neurons in the dorsal horn
= visceral disorders felt as cutaneous pain.
UNDERSTAND ANTEROLATERAL PATHWAY
!
know lesion type questions
is it ipsilateral or contralateral
is pain processed by a single cortical region?
no
Pain in processed by diverse and distributed networks / significance unclear
what is an example of peripheral sensitixation
hyperlagesia
what is hyper algesia
noxious stimulus that causes MORE pain than it should
talk about the chemistry of sensitixation
1) Nociceptors are depolarized by chemicals released in the environment around the terminal
2) Nociceptors release substances that contribute to inflammatory processes
3) Some chemicals sensitize the terminals of nociceptors so as to reduce their threshold
4) After sensitization of “pain fibres”, normally non- painful stimuli can cause pain
Protect injured area + promote healing & guard against infection
(↑ blood flow + white cells migration)
what is an example of central sensitization
allodynia
what is allodynia
painful reaction to non noxious stimuli
Pain not felt constantly (sensation = light stroking of sunburned skin)
wh
at are two pain modulation tecniques
gate theory
endogenous opiods
what are examples of exogenous ways to relive pain
opioids
cannabis
is acute pain useful
yes
is chronic pain useful
she never answered this lol
