Voluntary Motion Flashcards

1
Q

What are the 4 main cortical areas associated with production of voluntary motion?

A

primary motor cortex

supplementary motor cortex

premotor cortex

parietal cortex areas

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

How does your brain get input to enable motor actions based on visual input?

A

V2 –> dorsal visual pathway to parietal/frontal cortex

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

What is the first part of reaching motion (creating a rough map of space around you)?

A

info from visual cortex –> V6a, PEc, MIP and VIP in parietal cortex –> VIP (ventral intraparietal area) makes rough map of space around you

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

Where do signals go after the VIP in the reaching process?

A

VIP –> F4 in premotor cortex = detailed map of space around you

(neurons are excited by proximity - closer the object is, the more they fire)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

What pathway in reaching gets visual information about where your arm is in space (NOT where the bowl is)?

A

Superior parietal cortex (V6a, etc) –> F2 in the premotor cortex –> map of your arm in relationship to your body and things around you is constructed

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

What are the visual cues of grasping related to?

A

the goal of what you intend to do

pay attention to the features of the item you’re interested in picking up

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

What does the anterior intraparietal area and PFG respond to?

A

seeing and object to grasp = visually dominant neurons

grasping an object = motor dominant

both seeing and grasping an object = visuomotor neurons

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

What is the Voluntary grasping path?

A

PFG/AIP –> F5 –> neurons fire w/ goal of the action

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

What does the premotor cortex do?

A

receives sensory info required to move (particularly F4 and F5)

dorsal - applies rules that det whether it is appropriate to move

IDs the intent of the motion and decides what to produce

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

What are the 2 divisions of the supplementary motor cortex and what do they do?

A

supplementary motor area (SMA): postural control during mvt

Pre-supplementary area (Pre-SMA): plans the motor program required to make the action occur

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

If you are going to get candy from a bowl, what has your pre-SMA done?

A

identified the sequence of how to do the movements

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

Where is the primary motor cortex?

What does it do?

A

precentral gyrus

controls specific movements

regions of body that do fine motions have proportionally high representation

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

How are the columns of the primary motor cortex arranged?

A

each column produces a specific movement (not a specific muscle)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

What cerebral layer are Betz cells located?

A

V

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

What layer of the primary motor cortex receives sensory input?

A

layer IV

relatively small here compared to other parts of the brain

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

What characterizes layer V of the primary motor cortex?

A

output for the corticospinal (pyramidal) pathway

17
Q

How many sets of neurons are in each column of the primary motor cortex?

A

appear to be 2 sets:

one to start the motion

one to maintain it as long as necessary

18
Q

How are neighboring columns of the primary motor cortex related?

A

neighboring columns control related motions, not neighboring muscles

19
Q

What are the 2 types of columns of the primary motor cortex?

A
  1. on/off for agonist muscles
  2. off/on for the antagonist muscle
20
Q

What is the cerebellum’s role in voluntary motion?

A

sequence complex actions

correct force/direction

balance and eye movements

learning of complex actions

21
Q

What are the 2 parts of the spinocerebellum and what do they do?

A

central = postural control

either side of vermis = force and direction of motion

22
Q

Where is the cerebrocerebellum and what does it do?

A

lateral regions of the cerebellum

plan complex motions

sequence of motions

23
Q

Where is the vestibulocerebellum and what does it do?

A

flocculonodulus

balance/ eye movements

future - not current

24
Q

What part of the cerebellum does outputs?

A

deep cerebellar nuclei:

dentate nucleus (most lateral)

fastigial nucleus

interpositus (most medial): globose, emboliformis

25
How are postural adjustments to ongoing motions accomplished?
Inputs: vestibular, visual and auditory, efferent copy --\> to spinocerebellum outputs: interpositus n, fastigial n --\> rubrospinal tract
26
How are ballistic motions controlled via the cerebellum?
inputs: muscle afferent, efferent copy --\> lateral spinocerebellum outputs: interpositis --\> rubrospinal tract
27
What is an efferent copy?
what brain sends to muscle of the expected motion sent to cerebellum so it can mediate/alter motion
28
How is the sequencing of rapid movements and the planning of complex motions accomplished via the cerebellum?
inputs: all regions of cerebral cortex --\> cerebrocerebellum outputs: dentate --\> back to cortex
29
How is the control fo eye movement and balance, particularly in the future accomplished via the cerebellum?
input: vestibular apparatus (direct or indirect) --\> vestibulocerebellum output: fastigial nucleus --\> vestibular nuclei --\> ascend or descend
30
Without the basal ganglia, how is voluntary motion affected?
won't be able to initiate motion or will get stuck at start and can only repeat starting action
31
How do the basal ganglia work?
inhibition and withdrawal of that inhibition --\> to start movement excess of GABA
32
What is the nigrostriatal path?
from SNPC --\> to striatum = caudate and putamen tonically active dopaminergic
33
What type of receptor is used in the direct and indirect pathways?
D1 = direct D2 = indirect
34
What is the basic direct path?
SNPC -- dopamine D1 --\> striatum -- GABA --\> SNPR and GPi -- GABA --\> Thalamus \* allows motion when active
35
What is the indirect pathway?
SNPC --Dopamine D2 --\> striatum --GABA --\> GPe -- GABA --\> subthalamic nucleus -- EAA --\> SNPR and GPi -- GABA --\> Thalamus \*opposes motion when active
36
What is the intrastriatal cholinergic system?
btw the nuclei of the striatum effects: excitatory, in particular to indirect path
37
What do you need to activate the indirect path?
intrastriatal cholinergic pathway EAA inputs from the cortex
38
How does the brain get around muscles spindle reflexes?
if the brain activates the alpha motoneuron, also activates gamma-motoneuron for spindles in contracting muscle if it inhibits alpha motoneuron, will also inhibit gamma motoneuron in antagonist muscle