Viral Hepatitis and autoimmune hepatitis

Question 1

Name the characteristics of Hep. A

Answer 1

Family: Picorna
Generation: RNA 
Transmission: fecal-Oral 
Ono.city: No 
Complication: Acute liver Failure or Death

Question 2

Name the characteristics of Hep. B

Answer 2

Family: Hepadana 
Generation: DNA
 Transmission: sexual, Parenteral, Oral 
Ono. City: yes 
Complication: liver cancer

Question 3

Name the characteristics of Hep. C

Answer 3

Family: Flavi 
Generation: RNA
Transmission: Parental Sexual 
Ono. city: Yes 
Complication: liver Cancer

Question 4

Name the characteristics of Hep. D

Answer 4

Family: Delta 
Generation: RNA 
Transmission: PNP
Ono.city: N/A 
Complication: Co-infection with Hep. B

Question 5

Name the characteristics of Hep. E

Answer 5

Family: Calci 
Generation: RNA 
Transmission: fecal- oral 
Ono. city: No 
Complication: Association with Pregnancy

Question 6

What are the risk for Hep. B

Answer 6

People with sexually transmitted diseases
Men to Men
IV drug users
Infant born form HBV mothers
More than 1 sexual partners in the last 6 months
Health care workers
Hemodialysis patients

Question 7

What are the markers for Hep. B

Answer 7

HBsAg- acute or chronic infection
Anti-HBs - markers of immunity
Hepatits B core antibody (anti-HBC)- current or prior infection
IgM - indicative of infection in the previous 6 months
IgG - more distant HBV infection that is resolving
HBeAg - high infectivity
anti-HBe - correlates w/ low rate replication
HBV-DNA - active replication great for monitoring treatment

Question 8

What are the characteristics of an acute viral hepatitis

Answer 8

mottled appearance
lympoplasmacytic infiltrate
limited portal inflammations
necrosis of hepatocyte

Question 9

What are the characteristics of chronic viral hepatitis

Answer 9

lymphoplasmacytic infiltrate
mononuclear portal infiltrate
scarring necrosis

Question 10

What are the types of autoimmune hepatitis

Answer 10

type 1 and 2

Question 11

What is autoimmune hepatitis

Answer 11

it is a chronic, autoimmune disease of the live that occurs when the body’s immune system attacks liver cells and causes inflammation.

Question 12

What are characteristics of type 1 autoimmune hepatitis

Answer 12

middle age women
Anti-smooth muscle antibody
Anti-nuclear antibody

Question 13

What are the characteristics of type 2 autoimmune hepatitis

Answer 13

in children and teenagers

Anti-LKM1 antibody

Question 14

What is the treatment for autoimmune hepatitis

Answer 14

Corticosteroids

Question 15

What are the drugs in drugs induced liver damage

Answer 15

acetaminophen 
isoniazid 
methotrexate 
amiodarone 
statins

Question 16

What are the notes of acetaminophen

Answer 16

most common hepatotoxin cause acute liver failure
P450 system
Elevated LFT greater than 10g
necrosis around zone III
treatment: N-acetylcyst increase synthesis of glutathione

Question 17

What are the notes on isoniazid

Answer 17

Anti-TB drug

Question 18

What are the notes on methotrexate

Answer 18

anti-cancer drug

Question 19

What are the notes on amiodarone

Answer 19

anti-arrhythmic drug

Question 20

What are the notes on statins

Answer 20

anti-cholesterol drugs