Hepatic diseases and conditions Flashcards
What is hepatorenal syndrome
medical condition that consist of rapid deterioration in kidney function. There vasodilation in lungs due to Nitric oxide.
What are characteristics of hepatorenal syndromes
its over perfusion compared to ventilation. SOB is worse in upright position and there is hypoxemia low levels of O2 in arteries.
also, rapid renal failure w/ patient
rise in BUN and creatinine levels
fall in GFR
What is hemochromatosis
it is excess iron absorption that deposits in liver, pancreas, heart, joints, endocrine organs
What ancestry is common to hemochromatosis
Northern European
What are the causes of hemochromatosis
Primary: Heredity haemchromatosis (HFE gene - C282Y)
Secondary: transfusions, long term hemodialysis, hemolytic anemia
What are the symptoms of hemochromatosis
Bronzing of skin, arthritis cirrhosis, restrictive cardiomyopathy, Hepatocellular carcinoma, DM, Chronic pancreatitis, infertility
What wilson’s disease
hepatocellular degeneration where there is impaired copper excretion into bile
What are the signs and symptoms of wilson’s disease
Liver- hepatosplenomegaly
Brain - dementia, Movement issues, depression
Eyes: kayser- Flescher ring, Cu deposits in Descent membrane
What do you measure for Wilson disease
Ceruloplasmin
What is alpha-1 anti-trypsin Def.?
Autosomal recessive where the protein folding is affected and accumulates in the liver.
What causes alpha-1 anti-trypsin def. ?
Panacinar Emphysema
What is Hepatic Tumor?
It is a benign glandular epithelia tumor
What is it associated with Hepatic tumor
OCP
What are the risk factors or causes of Hepatic tumor
Hepatitis B and C Hemochromatosis Wilson's Disease Alpha-1 anti-trypsin Primary Biliary cirrhosis
What is the diagnostic test for hepatic tumor
AFP
