Alcoholic hepatitis and more Flashcards
What is alcoholic liver disease
a term that encompasses the liver’s develop after overconsumption of alcohol
What are the types of alcoholic liver diseases
Hepatocellular steatosis or fatty liver
Alcoholic hepatits
Liver Cirrhosis
What is hepatocellular steatosis
it is an accumulation of fatty acid in the liver cells. lips droplet that accumulate in the liver cells. it is reversible
What is alcoholic hepatitis
inflammation of hepatocytes through alcohol.. it leads to the hepatocytes swelling and necrosis. it is characterized by Mallory Pink bodies in the hepatocytes
What is Liver cirrhosis
it is a late stage of serious liver (Hepatocellular carcinoma) disease marked by inflammation, fibrosis. it appears as enlarged, pale, yellow
What are the characteristics of a fatty liver
Painful
hepatomegaly
no fever
no neutrophilic leukocytes
What are the characteristics of alcoholic hepatitis
painful fever hepatomegaly neutrophilic leukocyte ascites GI bleeding ( varices ) AST> ALT Increased GGT and ALP Increased conjugated and PT
What is NAFLD
The prescience of hepatic steatosis or Fatty liver in the absence of alcohol consumptions.
What causes NAFLD
Metabolic syndrome and DM and 2 of the following: Blood Pressure Dyslipidemia Central obesity microalbuminuria
What is acute liver failure
the rapid development of hepatocellular dysfunction specifically coagulopathy and mental status changes in the patient w/o liver disease
What are the compilation of acute liver disease
Jaundice scleral icterus hepatic encephalopathy Asterixis coagulopathy portal hypertension heptaorenal syndrome
What is chronic liver failure and cirrhosis
conditions in which the liver does not function properly due to the long term damage that usually takes months or years.
What are the common causes of chronic liver failure
Chronic hepatitis B and C
Alcoholic
NAFLD
other causes: Hemochromatosis Wilson disease Alpha-1 antitrypsin def primary biliary cirrhosis
What are the manifestations of chronic liver disease
Jaundice Pruritis Increased Estrogen Palmar erythema Spider anigomas hypogonadism Gynecomastia Xantheslesma Portal hypertension
What are the drugs that cause gynecomastia
Some Drugs Create Awesome Knockers
Spironolactone Digitalis Cimetidine Alcohol Ketoconazole
What is the blood supply
Portal vein, Hepatic Vein
What are complications with portal hypertension
Esophageal varices
splenomegaly
melena
Ascites, Hemorrhages, Caput Medusa
What is ascites
it is excess fluid accumulation in the peritoneal cavity
What are the physical exam of ascites
bulging flanks
shifting dullness fluid wave test
What is the SAAG score
Serum albumin to Ascites albumin
> 1.1g = cirrhosis, portal HTN
What is the treatment of ascites
paracentesis
What are the complications to ascites
Spontaneous Bacterial Peritonitis
Bacterial Infection in peritoneum
Patient w/ worsening
ascites w/ fever, chills, abdominal pain
What is the diagnostic criteria of ascites
absolute neutrophil count > 250 cells
What is the MCC of ascites
E.Coli
