Vent Pharm NMB Reversal - QUIZ

Question 1

Neostigmine reverses neuromuscular blockade through which of the following actions?

a) Enhancement of Acetylcholinesterase at the neuromuscular junction
b) Inhibition of acetylcholinesterase at the neuromuscular junction
c) Chelates and decreases free Rocuronium, causing passive diffusion away from the neuromuscular junction
d) Direct agonism of the nicotinic receptors

Answer 1

b) Inhibition of acetylcholinesterase at the neuromuscular junction

Question 2

Sugammadex works to reverse neuromuscular blockade caused by Rocuronium through which of the following?

a) Enhancement of Acetylcholinesterase at the neuromuscular junction
b) Chelates and decreases free Rocuronium, causing passive diffusion away from the neuromuscular junction
c) Direct agonism of the nicotinic receptors
d) Inhibition of acetylcholinesterase at the neuromuscular junction

Answer 2

b) Chelates and decreases free Rocuronium, causing passive diffusion away from the neuromuscular junction

Question 3

Which of the following is true regarding the pharmacokinetics of Sugammadex?

a) It is bound to plasma proteins
b) It is metabolized hepatically and metabolites excreted in the urine
c) It is excreted unchanged renally and enhances Rocuronium renal excretion
d) Its rate of excretion is dose dependent and requires intact renal function

Answer 3

c) It is excreted unchanged renally and enhances Rocuronium renal excretion

Question 4

Neostigmine causes which of the following adverse reactions.
Select ALL that apply.
a) Fasciculations
b) Hepatotoxicity
c) Urinary retention
d) Bradycardia
e) Bronchoconstriction
f) Tachyarrhythmias

Answer 4

d) Bradycardia

e) Bronchoconstriction