Medications Affecting the RAAS

Question 1

Vasopressin Regulates the RAAS system through:
Inhibits angiotensin 1 
Inhibits angiotensin conversion
Inhibits Renin release 
Inhibits aldosterone

Answer 1

Inhibits Renin release

Question 2

ACE inhibitors:

Increase retention of sodium and chloride ions

Block the conversion of angiotensin I to angiotensin II

Increase vascular smooth muscle tone

Increased aldosterone secretion

Answer 2

Block the conversion of angiotensin I to angiotensin II

Question 3

Which of the following is true regarding the pharmacokinetics of ACE inhibitors?

ACE inhibitors do not cross the placenta

The hypotensive effect is greater in agents with higher plasma levels

ACE inhibitors are metabolized by the liver

ACE inhibitors are poorly absorbed from the GI tract

Answer 3

The hypotensive effect is greater in agents with higher plasma levels

Question 4

Renin is released into circulation by all of the following, except:

Stimulation of the renal sympathetic nerves by B1 agonists

Release of Aldosterone

A hypotensive state due to hypovolemia

A fall in sodium concentration in part of the distal convoluted tubule

Answer 4

Release of Aldosterone

Question 5

Which of the following patients are at risk for adverse hypotension with ACE inhibitor treatment?

Concurrent loop diuretic use

High sodium diets

Renal failure

Low circulating renin levels

Answer 5

Concurrent loop diuretic use

Question 6

“The effects of Angiotensin II antagonists are similar to ACE inhibitors in that they decrease vasoconstriction and aldosterone release.” True or False?

Answer 6

True

Question 7

Which of the following describe the mechanism of action of Angiotensin II antagonists:

Selectively bind to angiotensin II receptors

Non- selective binding to angiotensin II receptors

Inhibit aldosterone

Inhibit the breakdown of bradykinin

Answer 7

Selectively bind to angiotensin II receptors

Question 8

Due to its specific V receptor activity, Desmopressin is useful in the treatment of which of the following?

Hypernatremia

DKA

Diabetes insipidus

Hypokalemia

Answer 8

Diabetes insipidus

Question 9

Angiotensin II antagonist adverse reactions are similar to ACE inhibitors, with the exception of:

Hyperkalemia

Angioedema from hypersensitivity

Renal perfusion impairment

Bradykinin mediated cough

Answer 9

Bradykinin mediated cough

Question 10

“In both normal and hypertensive patients with intact LV function, ACE inhibitors have a profound effect on cardiac output.” True or False?

Answer 10

False

Question 11

Select all that apply to ACE inhibitors effects on the cardiovascular system:

Reduce strictly diastolic pressure

Reduced preload

Increased glomerular capillary pressure

Increase systolic wall stress

Reduced afterload

Answer 11

Reduced preload

Increased glomerular capillary pressure

Reduced afterload