Cardiac Pharm - Reversal Agents - QUIZ

Question 1

Please match the following agent with their reversal treatment:

a) TNK
b) Warfarin
c) Dabigatran
d) Heparin
i) Protamine
ii) Vitamin K + PCC
iii) Idarucizumab
iv) TXA + fibrinogen

Answer 1

a) TNK = iv) TXA + Fibrinogen
b) Warfarin = ii) Vitamin K + PCC
c) Dabigatran = iii) Idarucizumab
d) Heparin = i) Protamine

Question 2

Prothrombin Complex Concentrate replaces which of the following factors? 
Select ALL that apply.
a) X
b) IX
c) Von Willebrand factor 
d) III
e) VII

Answer 2

a) X
b) IX
e) VII

Question 3

Idarucizumab acts as:

a) Non-competitive antagonist of dabigatran
b) Competitively binds with thrombin blocking dabigatran
c) Replacement of coagulation factors
d) Specific neutralizing antibody

Answer 3

d) Specific neutralizing antibody

Question 4

Protamine can cause which of the following if given too rapidly?

a) HTN
b) Thrombus formation
c) Anaphylactoid reaction
d) Tachycardia

Answer 4

c) Anaphylactoid reaction

Question 5

Which of the following is true regarding Vitamin K pharmacokinetics and routes of administration for reversal of Warfarin’s effects?

a) Subcutaneous administration has moderate and slow absorption
b) IV administration has an onset of 4-6 hours
c) IM administration has rapid distribution
d) PO route has rapid absorption

Answer 5

b) IV administration has an onset of 4-6 hours

Question 6

Which of the following is true regarding FFP vs PCC ?

a) Is a PCC alternative for less acute bleeding
b) PCC requires crossmatching prior to administration
c) FFP results in a faster reversal with less volume overload
d) PCC has lower efficacy for improving INR

Answer 6

a) Is a PCC alternative for less acute bleeding

Question 7

There is no specific reversal agent for antiplatelets, however, which of the following agents improve platelet function: ? 
Select ALL that apply.
a) Desmopressin
b) Protamine
c) Vitamin K
d) TXA

Answer 7

a) Desmopressin

d) TXA

Question 8

Through which of the following mechanisms does DDAVP improve platelet function:

a) Through activation of prothrombin
b) Through direct deactivation of Cox1 inhibition
c) Through release of von Willebrand factor
d) Through increased calcium reabsorption

Answer 8

c) Through release of von Willebrand factor