Diuretics - QUIZ

Question 1

There is substantial risk for adverse effects with diuretic use, thus it is important to understand their pharmacokinetics and pharmacology. True or False?

Answer 1

True

Question 2

Diuretics are classified by which of the following:

Select all that apply.

a) Adverse effects
b) Mechanism by which they inhibit
c) Endogenous compounds
d) Predominant site of action

Answer 2

b) Mechanism by which they inhibit

d) Predominant site of action

Question 3

Which of the following is true regarding Diuretics and nephrotoxicity?

a) Diuretics action on various ion channels causes increased renal oxygen demand
b) Diuretics clearance of venous congestion results in renal damage
c) Inappropriate use of diuretics is the cause of renal damage with their use
d) Diuretics are inherently nephrotoxic

Answer 3

c) Inappropriate use of diuretics is the cause of renal damage with their use

Question 4

Carbonic anhydrase Inhibitors mechanism of action is a result of:

a) Increases reabsorption of sodium bicarbonate in the distal tubule
b) Increases reabsorption of sodium bicarbonate in the proximal tubule
c) Increases reabsorption of sodium bicarbonate in the distal dubule
d) Inhibits reabsorption of sodium bicarbonate in the proximal tubule

Answer 4

d) Inhibits reabsorption of sodium bicarbonate in the proximal tubule

Question 5

Hypokalemic alkalosis is a common adverse reaction related to which of the following diuretic classes:

Select all that apply.

a) Potassium sparing diuretics
b) CA Inhibitors
c) Loop diuretics
d) Distal convoluted tubule diuretics

Answer 5

b) CA Inhibitors
c) Loop diuretics
d) Distal convoluted tubule diuretics

Question 6

Which agent produces its action by acting on the proximal tubule?

a) Thiazide diuretics
b) Potassium-sparing diuretics
c) Inhibitors of carbonic anhydrase
d) Loop diuretics

Answer 6

c) Inhibitors of carbonic anhydrase

Question 7

Thiazide diuretics exert their effects through:

a) Increase GFR
b) Inhibit sodium reabsorption in the distal convoluted tubule
c) Encourage glucose excretion in the distal convoluted tubule
d) Inhibit sodium reabsorption in the proximal convoluted tubule

Answer 7

b) Inhibit sodium reabsorption in the distal convoluted tubule

Question 8

Loop diuretics exert their effects through:

a) Blockade of Na channels in the ascending loop of Henle
b) Blockade of K channel in the descending loop of Henle
c) Blockade of Na/K/Cl channel in ascending loop of Henle
d) Blockade of Na/K/Cl channel in the descending loop of Henle

Answer 8

c) Blockade of Na/K/Cl channel in ascending loop of Henle

NOTE: quiz listed a) as the correct answer, it’s being looked into…

Question 9

Which of the following is true regarding concurrent use of Thiazide diuretics in combination with a loop diuretic?

a) Increased hepatic toxicity
b) Avoidance of rebound water retention through sodium excretion
c) Thiazides increase chronic furosemide resistance
d) Effect albumin’s absorption of furosemide

Answer 9

b) Avoidance of rebound water retention through sodium excretion

Question 10

All of the following are true regarding Lasix pharmacokinetics, except:

a) Lasix has a consistent oral bioavailability at 50%
b) Lasix is metabolized by the liver
c) IV Lasix peak action occurs at 30 minutes
d) Lasix is freely filtered into the tubule to exert its effects

Answer 10

c) IV Lasix peak action occurs at 30 minutes [Lasix = LAsts SIX hours]

Question 11

Which of the following is true regarding loop diuretic dose dependence?

a) Effect depends on the duration of time that the concentrations are above threshold concentration
b) There is greater efficacy above ceiling concentration
c) There is still mild efficacy below the threshold concentration
d) IV administration achieves higher levels and longer duration of action

Answer 11

a) Effect depends on the duration of time that the concentrations are above threshold concentration