Vent Pharm Neuromuscular Blocking Agent - QUIZ

Question 1

Match the following Neuromuscular Blockades with their correct Mechanism of Action:

a) Depolarizing neuromuscular blockade
b) Non-Depolarizing neuromuscular blockade
i) Acetylcholine receptor agonism causing hyperpolarization & prolongs potential at end plate
ii) Competitively blocks acetylcholine at the nicotinic receptors

Answer 1

a) Depolarizing neuromuscular blockade = i)

b) Non-Depolarizing neuromuscular blockade = ii)

Question 2

Which of the following is true regarding potentiation of NDMB effects?

a) Hypothermia will prolong duration
b) Magnesium will shorten onset time
c) Calcium will prolong the action of blockade
d) Anti-epileptics will increase sensitivity

Answer 2

a) Hypothermia will prolong duration

Question 3

Elderly and pediatric patients require lower doses of NDMB agents.

True or False?

Answer 3

False

Question 4

Which of the following is true regarding of Succinylcholine interactions?

a) NDMB reversal agents shorten the duration of action of Succinylcholine
b) Prolonged exposure to succinylcholine results in increased receptor resistance to the medication
c) Liver disease alters pseudocholinesterase and increases duration of action
d) Succinylcholine has decreased effect in denervation

Answer 4

c) Liver disease alters pseudocholinesterase and increases duration of action

Question 5

Which of the following NDMB cause Histamine mediated cardiovascular effects?

a) Vecuronium
b) Cisatracurium
c) Rocuronium
d) Atracurium

Answer 5

d) Atracurium

Question 6

Select the contraindications to Succinylcholine use:
Select ALL that apply.
a) Malignant Hyperthermia
b) Pulmonary HTN
c) Heart failure 
d) Severe burns
e) Severe trauma 
f) Angle-closure glaucoma
g) Hepatic failure
h) Pathology causing denervation

Answer 6

a) Malignant Hyperthermia
d) Severe burns
e) Severe trauma
f) Angle-closure glaucoma
h) Pathology causing denervation

Question 7

Precaution should be taken using Succinylcholine in Pediatrics due to risk of bradycardia. True or False?

Answer 7

True

Question 8

Which of the following is true regarding elimination of NMBA ?

a) Rocuronium is primarily excreted renally
b) Cisatracurium clearance is not affected by renal or liver disease
c) Vecuronium elimination is affected by Pseudocholinesterase inhibition
d) Rocuronium is mostly cleared by Hoffman elimination

Answer 8

b) Cisatracurium clearance is not affected by renal or liver disease

Question 9

Which of the following is true regarding Neuromuscular blocking agents and denervated Junctions? Select ALL that apply.

a) Immature junctions are more sensitive to NDMB
b) Immature junctions are more sensitive to depolarizing agents
c) Immature Junctions have a 10-fold increase in mean channel open time increasing Potassium leak
d) Percentage of burns is not correlated with severity of hyperkalemic response
e) Highest risk for hyperkalemia with Succinylcholine use in burns is within the first 24 hours
f) All choices

Answer 9

b) Immature junctions are more sensitive to depolarizing agents
c) Immature Junctions have a 10-fold increase in mean channel open time increasing Potassium leak
d) Percentage of burns is not correlated with severity of hyperkalemic response
e) Highest risk for hyperkalemia with Succinylcholine use in burns is within the first 24 hours* (incorrect)