Venous Thrombus Flashcards
What type of thrombus is foudn in arteries?
platelet rich
What happens in venous thrombosis?
platelets aren’t activated; coag cascade is activated- fibrin rich
What is virchows triad?
stasis; vessel wall; hypercoagulability
What are the risk factors for VTE?
age; obestiy; pregnnacy; puerperium; oestrogen therpay; prev DVT/PE; trauma/surgery; malignancy; paralysis; infection; thrombophilia
What is the mechanism of increased thrombosis in thrombophilia?
decreased anticoagulant activity
What is factor V Leiden?
factor V has a base change resulting in inability for protein C and S to bind properly
What are the naturally occurring anticoagulants?
anti-thrombin; protein C and S
When should thrombophilia be suspected?
venous thrombosis <45 years; recurrent venous thrombosis; unusual sites e.g cerebral veins of upper limbs; Fhs
Which gives higher risk of thrombosis- APS or thrombophilia?
APS
What is the pathogenesis of APS
antibodes lead to conformational change in beta2 glycoprotein 1 which leads to activation of primary and secondary haemostasis and vessel wall abnormalities
what blood test is prolonged in APS?
APTT
What conditions are associated with lupus anticoagulants?
AI; lymphoproliferative; viral infection;s drugs; primary
