Brainscape's Knowledge GenomeTM

Browse over 1 million classes created by top students, professors, publishers, and experts.


See full index

Haematology > Intro to haemostasis > Flashcards

Intro to haemostasis Flashcards

1
Q

What is haemostasis?

A

arrest of bleeding and maintenance of vascular patency

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

What are the requirements of haemostasis?

A

permanenent state of readiness; prompt response; localised response; protection against unwated thrombosis

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

What is primary haemostasis?

A

formation of a platelet plug

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

What is secondary haemostasis?

A

formation of fibrin clot

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

What are the components of normal haemostatic system?

A

primary and secondary haemostasis; fibrinolysis and anticoagulant defences

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

What is the lifespan of platelets?

A

7-10 days

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

What is the result of endothelial damage?

A

exposing of collagen and release of von willebrand factor

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

What are the consequences of failure of platelet plugs?

A

spontaneous bruising and purpura (esp. in lowerl imbs); mucosal bleeding; intracranial haemorrhage; retinal haemorrhage

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

What is the screening test for primary haemostasis?

A

platelet count

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

Why might vitamin C deficiency result in increased bleeding?

A

need to make collagen

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

What is found on the outside of platelets?

A

negatively charged phospholipid with calcium stuck on

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

What is released with tissue damage that begins the fibrin clot?

A

tissue factor

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

What does tissue factor activate?

A

factor VII

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

What is the action of TF/VII?

A

activates factors V and Xa

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

What is the function of V/Xa complex?

A

changes prothrombin to thrombin

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

What are the actions of thrombin?

A

converts fibrinogen to fibrin; and activates VII/IXa

17
Q

What is the purpose of VIII/Xa?

A

activates V/Xa and amplifies the response from TF

18
Q

What is the difference between single and multiple clotting factor deficiencies?

A

single:usually hereditary whereas multiple are usually acquired

19
Q

What other name is prothrombin known by?

A

factor II

20
Q

What converts plasminogen to plasmin?

A

tissue plasminogen activator

21
Q

What is the action of plasmin?

A

convert fibrin to FDPs

22
Q

How are fibrin degredation products detected clinically?

A

d-dimers: cross-linked version of FDPs

23
Q

What does prothrombin time measure?

A

pathway through TF/VIIa ( intrinsic pathway)

24
Q

What does activated partial thromboplastin time measure?

A

pathway though VIII/IXa (extrinsic pathway)

25
Q

What are the naturally occurring anticoagulants?

A

anti-thrombin; protein C and S

26
Q

What are the functions of anti-thrombin?

A

inhibits TF/VIIa; V/Xa; VIII/IXa and thrombin

27
Q

How are Protein S and C activated?

A

thrombomodulin on endothelium binds to thrombin which activates PC and PS

28
Q

Waht are the actiosn of protein C and S?

A

inhibit V/Xa and VIII/IXa

29
Q

What is thrombophilia?

A

deficiency of naturally occurring anticoagulants

Haematology (29 decks)

Brainscape helps you reach your goals faster, through stronger study habits.
© 2024 Bold Learning Solutions. Terms and Conditions