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Haematology > Lymphadenopathy > Flashcards

Lymphadenopathy Flashcards

1
Q

What are macroovalocytes seen in?

A

B12/folate deficiency

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2
Q

What is chromosome fragility seen in?

A

Fanconi’s anaemia

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3
Q

What are the causes of lymphadenopathy?

A

lymphoma; infection; metastatic cancer; sarcoidosis; SLE

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4
Q

What are symptoms which suggest lymphoma?

A

itch without rash; alcohol induced pain; fatigue

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5
Q

what causes of lumps cause tender nodes?

A

infective causes

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6
Q

What is the consitency of nodes assoc. with lymphoma?

A

rubbery/soft

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7
Q

What is the consistency of nodes associated with infection?

A

hard

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8
Q

What does an irregular node suggest as a cause?

A

metastatic carcinoma

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9
Q

What causes lumps that are tethered?

A

metastatic carcinoma; sometimes bacterial

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10
Q

What would inflamed skin around the node suggest as a cause?

A

bacterial

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11
Q

What is the most common form of Hodgkins lymphoma?

A

nodular sclerosing

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12
Q

What protein is typically foudn on Reed Sternberg cells?

A

CD30

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13
Q

What protein is usually foudn in follicular NHL?

A

CD20

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14
Q

What is the chromosome abnormality seen with follicular NHL?

A

T(14:18)

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15
Q

What is the chromsome abnormality seen with mantle cell NHL?

A

T(11:14)

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16
Q

What is molecular analysis used for?

A

looks at patterns of gene expression to further classify lymphoma

17
Q

What is the general rule about the cells found in the lymphoma and the grade?

A

the more primitive the cell type of the lymphoma, the more aggressive the disease

18
Q

What is the difference in treatment between low and high grade NHLs?

A

low grade- chemo wont be curative as slow growing cells not all are active wehreas high grade, chemo can be curative

19
Q

What is significant about Burkitt’s lymphoma?

A

very aggressive and won’t be cured with standard high grade treatment

20
Q

What is significant about mantle cell lymphoma?

A

looks low grade on microscope but acts high grade

21
Q

what is significant about marginal zone NHL?

A

very slow-growing, often doesn’t need treatment

Haematology (29 decks)

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