Lymphadenopathy Flashcards
What are macroovalocytes seen in?
B12/folate deficiency
What is chromosome fragility seen in?
Fanconi’s anaemia
What are the causes of lymphadenopathy?
lymphoma; infection; metastatic cancer; sarcoidosis; SLE
What are symptoms which suggest lymphoma?
itch without rash; alcohol induced pain; fatigue
what causes of lumps cause tender nodes?
infective causes
What is the consitency of nodes assoc. with lymphoma?
rubbery/soft
What is the consistency of nodes associated with infection?
hard
What does an irregular node suggest as a cause?
metastatic carcinoma
What causes lumps that are tethered?
metastatic carcinoma; sometimes bacterial
What would inflamed skin around the node suggest as a cause?
bacterial
What is the most common form of Hodgkins lymphoma?
nodular sclerosing
What protein is typically foudn on Reed Sternberg cells?
CD30
What protein is usually foudn in follicular NHL?
CD20
What is the chromosome abnormality seen with follicular NHL?
T(14:18)
What is the chromsome abnormality seen with mantle cell NHL?
T(11:14)
What is molecular analysis used for?
looks at patterns of gene expression to further classify lymphoma
What is the general rule about the cells found in the lymphoma and the grade?
the more primitive the cell type of the lymphoma, the more aggressive the disease
What is the difference in treatment between low and high grade NHLs?
low grade- chemo wont be curative as slow growing cells not all are active wehreas high grade, chemo can be curative
What is significant about Burkitt’s lymphoma?
very aggressive and won’t be cured with standard high grade treatment
What is significant about mantle cell lymphoma?
looks low grade on microscope but acts high grade
what is significant about marginal zone NHL?
very slow-growing, often doesn’t need treatment
