Arterial thrombosis and Anti-platelets

Question 1

What agents are released from platelets that leads to aggregation of platelets?

Answer 1

ADP; thromboxane A2

Question 2

How do platelets bind to subendothelial collagen?

Answer 2

glycoprotein Ib and vWF

Question 3

How do platelets attach to each other?

Answer 3

GPIIBIIIa and fibrinogen

Question 4

What is the MOA of asprin?

Answer 4

inhibits COX whcih is necessary to produce thromboxane A2

Question 5

How is thromboxane A2 synthesised?

Answer 5

arachiodonic acid–PGs– TXA2

Question 6

What are the SE of aspirin?

Answer 6

bleeding; Gi ulceration; bronchospasm

Question 7

What is the action of clopidogrel and prasugrel?

Answer 7

ADP receptor antagonists

Question 8

What is the action of dipyridamole?

Answer 8

phosphodiesterase inhibitor- reduced cAMP (second messenger in platelet activation)

Question 9

What is the action of abciximab?

Answer 9

inhibt aggregation by inhibiting GP IIB/IIIa

Question 10

Why should anti-platelets be stopped 7 days before surgery?

Answer 10

tend to affect platelet function for their 7-10 day life span