uwolrd block Flashcards
FGF23
secereted from osteoccytes supresss 1 pha hydroxylase
explain phosphate filtration
dependant on GFR, therefore CKD although high PTH high phosphate.It leasds to magnesium retention
biopsy of aplastic anemia will reveal
hypocellular Bm with normal morphollogy hematopeotic stem cells
what is a good source of iron for menstrauting women and growing chidren
meat
what is psorasosis characterixed by
It is characterized histologically by clubbed rete ridges, hyperkeratosis, neutrophils in the stratum corneum, and perivascular lymphocytic infiltrate
Aminoglycodise moa
AGs irreversibly bind to bacterial 30S but not eukaryotic 40S; this causes genetic code misreading and bacterial protein synthesis inhibition. AGs also appear to impact translocation, whereby an aminoacyl-tRNA is shifted from the ribosomal A site (after initial binding) to the P site (after AA incorporation into the peptide chain during elongation) to the E site (after AA cleaving from its tRNA). The initial N-formylmethionine-tRNA notably binds at the P site.what is the function of th17
what is the function of th17
helps neutrophils migrate
moa of hydrops fetalis
profound anemia cause congestive hf
how is the px of child edema
shoes fir tightly/ ankle edema
clun cells what happens to it in chronic bronchitis
Club cells are found in the ciliated epithelium of bronchioles and secrete glycosaminoglycans and lysozymes, which help to break down mucus and maintain the integrity of the bronchial lining. In chronic bronchitis, the number of club cells is decreased rather than increased.
side effect of diethylpropion
pah
currant jelly sputum
lead to destruction of alveoli, resulting in bloody sputum with a currant jelly a
a patient comes with GERD alcohol use and is immunocomprimesd what can he have
klebseilla pneumonia
tdp 43 function and where is it ound
TDP-43 is a protein involved in DNA repair and transcription, and it becomes abnormally ubiquitinated in FTD. Pathologic TDP-43 is also found in patients with amyotrophic lateral sclerosis.
what is a complex of gamasecretase complex
presillin abnormal mutation =increases risk of alzehimers
pathomechanism of isolated systolic hypertension
loss of eastin increase collagen decreased compliance
cardiomyocyte changes in elderly
Response to cardiomyocyte dropout & ↑ afterload
Resting EF, SV & cardiac output maintained
↓ Maximal cardiac output
beta 2 integrin
Beta-2 integrin (CD18) helps leukocytes migrate from the bloodstream to tissue by binding to intercellular adhesion molecule-1 on the extracellular matrix of the endothelium. It also helps macrophages, neutrophils, and natural killer cells generate complement receptors, which recognize and phagocytose foreign peptide
what is l selectin
leukocyte bind to venule endothelium
what causes hydronephrosis after pelvic surgery
damage of ureter
which is more dependant on collateral circulation right venticle or left ventricle
left ventricle is dependant on collateral circulation
patients with impaired cell mediated immunity develop what scabies
crusted lesions
fetal hemoglobin vs adult
shorter lifespan
why enterohepatic circulation is increased in newborn
Finally, relative gut sterility in newborns results in decreased reduction of bilirubin to urobilinogen; instead, intestinal β-glucuronidase (which is synthesized both endogenously and by gut bacteria) deconjugates the bilirubin which allows it to be reabsorbed, therefore increasing enterohepatic circulation.
