Unit III Flashcards
The skin and its accessory skin structures make up the ___
integumentary system
The Functions of the Skin
- Organ of Protection
- The skin is an organ of regulation
- The skin is an organ of sensation
- Skin reduces water loss
- Excretes wastes
- The Skin serves as immune-competent system
Skin provides protection from mechanical impact and pressure, temperature variations, microorganisms, radiation and chemicals
Organ of Protection
___ is the precursor of vitamin D, which plays an essential role in the control of calcium and phosphorus metabolism
Cholesterol
___ produces 7-dehydrocholesterol (Cholesterol precursor)
Dermal Vitamin Synthesis
___ absorb calcium and promote bone growth, another name for Vitamin D3
Cholecalciferol (Vitamin D3)
___ binds in the kidney with Vitamin D binding protein for body utilization
Calcitriol
A steroid hormone its important role in regulating body levels of calcium and phosphorus, and in mineralization of bone
Calcitriol
senses heat or cold
thermoreceptor
senses “touch”
Meissner’s corpuscle
senses pain
nociceptor
senses “pressure”
pacinian corpuscle
Adhere cells to each other and to form a protective layer on the outside of the skin
keratin
Inform immune system for any microbes gaining entrance into the body
Langerhans cells
Detects, engulfs and destroys pathogens and apoptotic cells (cells that are no longer needed or are a threat to the organism)
Macrophage-like antigen of the epidermis
Found in the basal layer (stratum basale) of the skin, Responsible for forming tight junctions with the nerves of the skin
Keratinocytes
___ line the outer surfaces of organs and blood vessels throughout the body, as well as the inner surfaces of cavities in many internal organs
Epithelial cells
Layers of the skin
Epidermis
Dermis
Hypodermis
Upper most layer of the skin, A stratified epithelium, which protects like oropharynx that undergo wear-&-tear
Epidermis
Levels of the Epidermis
Stratum Basale
Stratum Spinosum
Stratum Granulosum
Stratum Lucidum
Stratum Corneum
Forms a strong bond between epidermis and dermis, A single layer of cells which grow & divide
Stratum Basale
forms epidermal ridges like the
fingerprints
Stratum basale
___ is produced within the skin in cells called melanocytes and it is the main determinant of the skin color of darker-skinned humans
Melanin
The epidermis contains three specialized cells:
Melanocytes
Langerhans cells
Merkel cells
___ are melanin-producing neural crest-derived cells located in the bottom layer (stratum basale) of epidermis
Melanocytes
two types of melanin
Eumelanin
Pheomelanin
Types of eumelanin
Brown eumelanin
Black eumelanin
___ is a dark pigment that predominates in black and brunette hair
Eumelanin
Small amount of ___ in the absence of other pigments apparently causes blond hair
brown eumelanin
The more ___ in your skin, the darker your skin will be.
eumelanin
___ is a lighter pigment found in red hair, and is concentrated in the redder areas of the skin such as the lips
Pheomelanin
___ progressive destruction of melanocytes
Vitiligo
___ is the inability to produce melanocytes
Albinism
Help protect by keeping microbes from entering the body. They are like the air traffic controllers of the immune system
Langerhans cells
Produced by division of stratum basale, Contain dentritic
(Langerhans) cells for immune response
Stratum spinosum “Spiny”
Essential for light touch sensation
Merkel cells
Cells shrink until cytoskeleton (microfilaments,
intermediate filaments, and microtubules) stick out.
Stratum spinosum “Spiny”
Composed of keratin & keratohyalin (protein structure found in granules in the stratum granulosum of the epidermis)
Stratum granulosum “grainy”
Keratin fibers creates a tightly interlocked layer of cells during dehydration and surrounded by keratohyalin
Stratum granulosum “grainy”