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Pharmacology > tumor genes and such > Flashcards

tumor genes and such Flashcards

1
Q

astrocytoma

A

PDGF, overexpression and autocrine loop,

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2
Q

subset of breast carincoma

A

egfr or receptor tyrosine kinase, amplification,

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3
Q

men 2a, 2b, sporadic medullary thyroid cancer

A

RET, egfr or receptor tyrosine kinase, point mutation

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4
Q

GIST

A

kit, stem cell growth factor receptor or cytokine recetpro, point mutation

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5
Q

RAS

A

gtp binding protein or gtpase, colon cancer, lung adenocarcinoma, pancreatic cancer, carcinomas, melanomas, lymphomas

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6
Q

CML and some types of ALL

A

BCR ABL 922

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7
Q

lung small cell carcinoma

A

L-myc, transcription factor, amplification

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8
Q

burkitt lymphoma

A

c-myc, trascritiopn factor, 8 14 heavy chain igh

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9
Q

neuroblastoma

A

n myc, amplificatino, transcription factor

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10
Q

mantle cell lymphoma

A

11 14 (CCND1, cyclind1, cyclin)

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11
Q

melanoma

A

cdk4, amplification, BRAF too

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12
Q

lung adenocarincoma

A

ALK, receptor tyrosine kinase,

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13
Q

follicular lymphoma

A

bcl2

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14
Q

diffuse large b cell lymphoma

A

bcl2

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15
Q

pappilary thyroid cancer

A

BRAF

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16
Q

chronic myeloproliferative disorders

A

JAK2, tyrosine kinase,

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17
Q

colorectal cancer (FAP)

A

APC, negative regulator of the b catenin/wnt pathway

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18
Q

breast ovarian and pancreatice cancer

A

BRCA1/BRCA2, dna repaire protein

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19
Q

melanoma, pancreatice cancer

A

p16, blocks g1 to s phase

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20
Q

DCC

A

colon cancer

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21
Q

DPC

A

deleted in pancreatic cancer, dpc4/smad4

22
Q

men 1

A

menin men 1

23
Q

NF1

A

NF1, neurofibromin which is a RAS activating GTPase

24
Q

NF2

A

merline (schwannomin) protein

25
Q

li fraumeni tumors

A

SBLA, sarcoma, breast, leukemia, adrenal gland

26
Q

tuberour sclerosis

A

TSC1 -> hamartin protein, TSC2 -> tuberin protein

27
Q

von hippal lndaue disease

A

VHL, inhibits hypoxia inducible factor 1a, causes increased vegf and pro;iferation

28
Q

wilms tumor (nephoblastoma)

A

WT1, transcription factor that regulates urogenital development

29
Q

aflatoxins

A

aspergillus, stored rice and grains, africa, hepatocellular carcinoma

30
Q

akylating agents

A

leukemia/lymphoma from cehmotherapy side effects 5-10 yrs down road

31
Q

alcohol

A

squamous cell carcinoma of oropharynxy and esophagus and heptocellular carcinoma

32
Q

arsenic

A

skin (sqamous cell carcionoma, women applied to their skin to make lighter), lung cancer (in smoke), and liver angiosarcoma

33
Q

asbestosis

A

bronchogenic carcinoma > mesothelioma

34
Q

cigareete smoke

A

bladder -> transitional cell carcionma
cervix -> cervical carcionma
esophagus -> squamous cell carcinoma/adenocarcinoma
kidney -> renal cell carcionoma
larynx -> squamous cell carcinoma
lung -> squamous cell and small cell carcinoma
pancrease -> pancreatic adenocarcinoma

35
Q

nitrosamines

A

smoked foods, responsible for gastric adenocarincomas in japan

36
Q

aromatic amines (benzidine, 2-naphthylamine)

A

cig smoke, urothehlial cell carcionoma of bladder

37
Q

vinly chloride

A

liver angiosarcoma, occupation exposure, used ot make PVC

38
Q

nickel, chromium, berylium, or silica

A

lung carincoma form occupational exposure

39
Q

CCL4

A

centrilobular necorisis and fatty change

40
Q

ionizing radiation

A

pappillary thyroid caricnoma, aml, cml

generates hydroxyl free radicals

41
Q

radon

A

lung cancer

42
Q

EBV

A

burkitt lympphoma, hoddking lymphoma, nasopharyngeal carcinoma, primary cns lymphoma in immnocompromised

43
Q

HBV, HCV

A

hepatocellular carcinoma

44
Q

HHV8

A

kaposi sarcoma

45
Q

hpv

A

cervical and penile/anal carcionoma (16 18) and head and neck cancers, vulva, vagina

46
Q

h pylori

A

gastric adenocarcinoma and malt lymphoma

47
Q

htlv1

A

adult t cell leukemia/lymphoma

48
Q

liver fluke (clnorcchis sinensis)

A

cholnagiocarcinoma

49
Q

schistosoma hematobium

A

bladder cancer (squamous cell)

50
Q

nonionizing (uvb sunlight is most common)

A

basal cell carcinoma, squamous cell carcinoma, melanoma of the skin

results in formation of pyrimidine dimers and DNA which are normall excised by restriction endonuclease

Pharmacology (33 decks)

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