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Pharmacology > autonomics > Flashcards

autonomics Flashcards

1
Q

a1 receptors (1 feature)

A

230 increase in intestinal and bladder spincter muscle contraction

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2
Q

a2 receptors

A

230 decreases lipoylisis, increase platelet aggregation, , decrease aqueous humor production

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3
Q

b1 receptor

A

increase lipolysis 230

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4
Q

b2 receptor

A

involved in hypokalemia, increase lipoylsis, 230

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5
Q

b3 receptor

A

increase lipolysis, increase thermogenesis in skeletal muscle, increase in bladder relaxation 230

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6
Q

m1 receptors

A

stimulates cognitive function, stimulates enteric nervous system

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7
Q

m2 receptors

A

230

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8
Q

m3 receptors

A

excorine glad secretions, (lacrimal, sweat, salivary, gastric acid), gut peristalsis, increase in insulin

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9
Q

d1 receptor

A

230

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10
Q

d1 receptor

A

230

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11
Q

h1 receptor

A

nasal and bronchial mucous production, vascular permeability and vasdoilation, contraction of bronchioles, pruitism pain

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12
Q

h2

A

230

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13
Q

amphetamine mech

A

releases stored catecholamines and inhibits reuptake

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14
Q

ephedrine mech

A

releases stored catecholamines

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15
Q

cocaine mech

A

reuptake inhibitor

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16
Q

TCA

A

reuptake inhibitor

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17
Q

how does a1 cause contraction in vascular smooth muscle?

A

through ip3 and increased Ca -> ca-calmodulin

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18
Q

how does b2 cause relaxation in vascular smooth muscle?

A

through increase camp-> pka -> phosphorylation of MLCK

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19
Q

how is nitric oxide formed and how does it cause relaxation?

A

formed by m3 on endothelium -> gq -> ca -> activated nitric oxide synthase -> increase NO -> guanlate cyclase -> increase cgmp -> phosphorylated mlcp

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20
Q

bathanechol

A

232

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21
Q

carbachol

A

232

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22
Q

methacholine

A

232

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23
Q

pilocarpine

A

232

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24
Q

galantamine

A

232

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25
Q

donezipil

A

232

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26
Q

rivastigmine

A

232

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27
Q

edrophonium

A

232

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28
Q

neostigmine

A

232

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29
Q

physostigmine

A

232

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30
Q

pyridostigmine

A

232

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31
Q

atropine

A

232

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32
Q

homatropine

A

233

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33
Q

tropicamide

A

233

34
Q

benztropine

A

233

35
Q

trihexyphenidyl

A

233

36
Q

glycopyrrolate

A

233

37
Q

hyocyamine

A

233

38
Q

dicyclomine

A

233

39
Q

ipratropium

A

233

40
Q

tiotropium

A

233

41
Q

oxybuntin

A

233

42
Q

solifenacine

A

233

43
Q

tolterodine

A

233

44
Q

scopolamine

A

233

45
Q

atropine uses

A

bradycardia and ophtalmic applications

46
Q

atropine organ effects

A

233

47
Q

atropine will not fix the following problems in cholinesterase OD

A

CNS or muscle (nicotinic receptors)

48
Q

atropine adverse effects

A

233

49
Q

albuterol

A

234

50
Q

terbutaline

A

234

51
Q

salmeterol

A

234

52
Q

formeterol

A

234

53
Q

dobutamine

A

234

54
Q

dopamine

A

234

55
Q

epinephrine

A

234

56
Q

fenoldopam

A

234

57
Q

isoproterenol

A

234

58
Q

midodrine

A

234

59
Q

mirabegron

A

234

60
Q

norepineprhine

A

234

61
Q

phenylephrine

A

234

62
Q

ephedrine

A

234

63
Q

cocaine

A

234

64
Q

amphetamine

A

234

65
Q

clonidine

A

235

66
Q

guanfacine

A

235

67
Q

alpha methyldopa

A

235

68
Q

phenoxybenzamine

A

235

69
Q

phentolamine

A

235

70
Q

prazosin

A

236

71
Q

terazosin

A

236

72
Q

doxazosin

A

236

73
Q

tamsulosin

A

236

74
Q

mirtazapine

A

236

75
Q

svt beta blockers

A

metoprolol, esmolol

76
Q

heart failure beta blockers

A

bisoprolol, carvedilol, metoprolo

77
Q

variceal bleeding and portal hypertension

A

nadolol, propranolol

78
Q

side effects of beta blockers

A

237

79
Q

partial beta agonists

A

atenolol (not acebutolol) and pindolol

80
Q

nebiviolol mech

A

cardiac selective b1 blockade and b3 receptor stimulation (increase nitric oxide syntahse and decrease tpr)

81
Q

what to avoid using beta blockers with

A

digoxin or ccv, can exacerbate heart block

Pharmacology (33 decks)

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