autonomics Flashcards
a1 receptors (1 feature)
230 increase in intestinal and bladder spincter muscle contraction
a2 receptors
230 decreases lipoylisis, increase platelet aggregation, , decrease aqueous humor production
b1 receptor
increase lipolysis 230
b2 receptor
involved in hypokalemia, increase lipoylsis, 230
b3 receptor
increase lipolysis, increase thermogenesis in skeletal muscle, increase in bladder relaxation 230
m1 receptors
stimulates cognitive function, stimulates enteric nervous system
m2 receptors
230
m3 receptors
excorine glad secretions, (lacrimal, sweat, salivary, gastric acid), gut peristalsis, increase in insulin
d1 receptor
230
d1 receptor
230
h1 receptor
nasal and bronchial mucous production, vascular permeability and vasdoilation, contraction of bronchioles, pruitism pain
h2
230
amphetamine mech
releases stored catecholamines and inhibits reuptake
ephedrine mech
releases stored catecholamines
cocaine mech
reuptake inhibitor
TCA
reuptake inhibitor
how does a1 cause contraction in vascular smooth muscle?
through ip3 and increased Ca -> ca-calmodulin
how does b2 cause relaxation in vascular smooth muscle?
through increase camp-> pka -> phosphorylation of MLCK
how is nitric oxide formed and how does it cause relaxation?
formed by m3 on endothelium -> gq -> ca -> activated nitric oxide synthase -> increase NO -> guanlate cyclase -> increase cgmp -> phosphorylated mlcp
bathanechol
232
carbachol
232
methacholine
232
pilocarpine
232
galantamine
232
donezipil
232
rivastigmine
232
edrophonium
232
neostigmine
232
physostigmine
232
pyridostigmine
232
atropine
232
homatropine
233
tropicamide
233
benztropine
233
trihexyphenidyl
233
glycopyrrolate
233
hyocyamine
233
dicyclomine
233
ipratropium
233
tiotropium
233
oxybuntin
233
solifenacine
233
tolterodine
233
scopolamine
233
atropine uses
bradycardia and ophtalmic applications
atropine organ effects
233
atropine will not fix the following problems in cholinesterase OD
CNS or muscle (nicotinic receptors)
atropine adverse effects
233
albuterol
234
terbutaline
234
salmeterol
234
formeterol
234
dobutamine
234
dopamine
234
epinephrine
234
fenoldopam
234
isoproterenol
234
midodrine
234
mirabegron
234
norepineprhine
234
phenylephrine
234
ephedrine
234
cocaine
234
amphetamine
234
clonidine
235
guanfacine
235
alpha methyldopa
235
phenoxybenzamine
235
phentolamine
235
prazosin
236
terazosin
236
doxazosin
236
tamsulosin
236
mirtazapine
236
svt beta blockers
metoprolol, esmolol
heart failure beta blockers
bisoprolol, carvedilol, metoprolo
variceal bleeding and portal hypertension
nadolol, propranolol
side effects of beta blockers
237
partial beta agonists
atenolol (not acebutolol) and pindolol
nebiviolol mech
cardiac selective b1 blockade and b3 receptor stimulation (increase nitric oxide syntahse and decrease tpr)
what to avoid using beta blockers with
digoxin or ccv, can exacerbate heart block
