pharmacology master

Question 1

ADHD tx

Answer 1

methylphenidate (ritalin), ampethamines (adderal)

Question 2

Bipolar disorder tx

Answer 2

lithium, valproic acid, carbamazepine, lamotrigine, atypical antipsychotics

Question 3

Bulemia nervosa tx

Answer 3

ssris

Question 4

depression tx

Answer 4

ssri and snri

Question 5

GAD tx

Answer 5

ssri, snri, buspirone, benzos

Question 6

panic disorder tx

Answer 6

ssri, venlafaxine

Question 7

schizo tx

Answer 7

atypical antipsychotics

Question 8

tourette syndrome

Answer 8

antipsychotics and tetrabenazine

Question 9

describe CNS stimulants and side effects

Answer 9

methypenidate (ritalin, ampehtamine derivative)

dextroamphetamine (adderal)

Methamphetamine

s/e anxiety, anoerxia, tachycardia, hypertension, insomnia

Question 10

NMS vs SS

Answer 10

both have:
HTN
Tachycardia
hyperthermia

NMS
lead pipe rigidity
hyporeflexia
ck and myoglobinuria

SS
clonus - ankle clonus
myoclonus - moving around too much
hyperreflexia
dilated pupils
hyperactive bowel sounds

Question 11

suffix for typical antipsychotics

Answer 11

haloperidol, pimozide, -azine

Question 12

mech of typical antipsychotics

Answer 12

d2 receptor antagnists

Question 13

high vs low potency typical antipsychotics

Answer 13

high potency
trifluoperazine, fluphenazine, halperidol
EPS

low potency
chlorpromazine, thioridazine
anticholinergic, antihistamine, a1 blockade

Question 14

typical antipsychotics non EPS effects

Answer 14

endocrine: dopamine receptor antagonism -> hyperprolactinmeia

Metabolic: dyslipidemia, weight gain, hyperglycemia

Antihistamine: sedation

a1 block: orthostatic hypotension

cardiac: qt prolongation

eye: chlorpromazine - corneal deposits
thioridazine - retinal deposits

Question 15

EPS of typical psychotics and tx

Answer 15

hours to days: acute dytonia (torticollis, oculogyric crisis, opisthotonic)

days to months: akathisia and parksonism

months to years: tardive dyskinesia (cant be treated)

tx: benztropine, trijexyphenidyl, diphenhydramine

benzos and b blockers for akathisia

Question 16

atypical antipsychotics suffixes

Answer 16

-apine, peridone, or aripiprazole

Question 17

atypical antipsychotics use

Answer 17

schizo - both + and - symptoms

Question 18

atypical antipsychotics s/e

Answer 18

all: prolonged qt interval, fewer eps and anticholinergic side effects than typicals
- pines - metabolic

clozapine - agranulocytosis (monitor wbcs) seizures

risperidone - hyperprolactinemi

Question 19

special use of clozapine

Answer 19

treatment resistant shizo, schizoaffective disorder, suicidality in schizophernia

Question 20

lithium s/e

Answer 20

tremor, hypothyroidism, poluria (nephrogenic diabetes), ebstein anomaly.

narrow window
thiazides cause toxicity

Question 21

buspirone use and benefit

Answer 21

GAD and no addiction and no interaction with alcohol, barbituates, benzos

Question 22

SSRI side effects

Answer 22

better than TCAs, gi distress, siadh, sexual (anorgasmia, dereased libido)

Question 23

SNRI special uses

Answer 23

diabetic neuropathy. duloxetine is also indicated for fibromyalgia

Question 24

snri side effects

Answer 24

increased bp. also stimulant effects sedation and nausea

Question 25

drugs that can cause serotonin syndrome and tx

Answer 25

maois, ssris, snris, tcas, tramadol, ondansetron, triptans, linezolid, mdma, dextromethorphan. cyproheptadine (5 ht2 receptor antagnoist) also antihistamine

Question 26

TCAs additional treatments

Answer 26

peripheral neuropathy, chronic pain, migraine prophylaxis. nocturnal enuresis (imipramine, but watch effects)

Question 27

TCAs effects and tx

Answer 27

sedation, a1 blocking effects including postural hypotension, anticholinergic (tachycardia, urinary retention, dry mouth). prolong qt.

convulsions, coma, cardiotoxicity. respiratory depression, hyperpyrexia, confusion and hallucinations in elderly due to anticholinergic effects

naho3

Question 28

MOAI special use

Answer 28

selegiline parkinson

Question 29

MOAI s/e

Answer 29

cns stimulation, hypertensive crisis, ingestion of tyramine found in like aged cheese and wine.

also Serotonin syndrome

need to wait two weeks before startin seroternergic drugs or stopping dietary restriction

Question 30

bupropion s/e

Answer 30

stimulant (tachycardia, insomnia), headache, seizures in anorexic pts and bulemic pts

Question 31

tazadone s/e

Answer 31

sedation, nausea, priapsim, postural hypotension