bone tumors

Question 1

osteoma benign or malignant

Answer 1

benign

Question 2

osteoma location

Answer 2

facial bones

Question 3

osteoma associated wiht?

Answer 3

gardner syndrome

Question 4

osteoid osteoma features

Answer 4

benign tumor of osteoblasts (that produce osteoid) surrounded by rim of reactive histiocytes

Question 5

osteoid osteoma who gets it?

Answer 5

young adults less than 25 (more common in males)

Question 6

osteoid osteoma location?

Answer 6

arises in the cortex of long bones (eg proximal femur diaphysis region)

Question 7

osteoid osteoma presentation

Answer 7

nighttime bone pain that is relieved with aspirin

Question 8

osteoid osteoma imaging

Answer 8

reveals a bony mass less than 2cm that has a radiolucent core (osteoid)

Question 9

osteoblastoma mass size

Answer 9

larger than 2 cm

Question 10

osteoblastoma location

Answer 10

vertebrae

Question 11

osteoblastoma aspirin?

Answer 11

no, doesnt relieve

Question 12

osteochondroma who gets it?

Answer 12

males less than 25, most common tummor

Question 13

osteochondroma features

Answer 13

bony exostosis (bony overgrowth of cartilage) with chondoird (cartilagnoius cap)

Question 14

osteochondroma transformation

Answer 14

cartilage cap can rarely transform into chondrosarcoma

Question 15

osteosarcoma feature?

Answer 15

malignant proliferation of osteoblasts

Question 16

osteosarcoma who gets it?

Answer 16

its a bimondal distribution 10-20 years get primary and >65 get secondary

Question 17

osteosarcoma risk factors

Answer 17

familal RB, in eldery - paget disease and radiation exposure

bone infarcts, li fraumeni syndrome (germline mutaiton in p53)

Question 18

osteosarcoma location

Answer 18

arises in the metaphysis of long bones, usually distal femur or proximal tibia.

Question 19

osteosarcoma presents as

Answer 19

pathologic bone fracture

Question 20

osteosarcoma imaging features

Answer 20

destructive mass with suburst appearance and lifting of the periosteum (codman triangle)

Question 21

giant cell tumor features

Answer 21

locally agressive benign tumor of stromal cells (neoplastic cells) and multinucleated giant cells; can recur

Question 22

giant cell tumor what do the multinucleated giant cells do?

Answer 22

they release RANK-L and causes lytic soap bubble lesions

Question 23

giant cell tumor occurs in?

Answer 23

20 40 years old

Question 24

giant cell tumor another name?

Answer 24

“osteoclastoma”

Question 25

giant cell tumor location

Answer 25

arises in the epiphysis of long bones, usually the distal femur or proximal etibia (region of the knee)

Question 26

ewing sarcoma features

Answer 26

malignant proliferation of poorly differntiated ceels derived from neuroectoderm

anaplastic small round blue cells

extremely aggresive with early mets but responsive to chemo

Question 27

ewing sarcoma who gets it?

Answer 27

boys less than 15

Question 28

ewing sarcoma location

Answer 28

diaphysis of long bones, pelvis, scapula, ribs

Question 29

ewing sarcoma x ray

Answer 29

onion skinning, becaue tumor grows in the medullary cavity and the periositum reacts and layers

Question 30

ewing sarcoma what can it be confused with?

Answer 30

chronic osteomyelitis or lymphoma

Question 31

ewing sarcoma how to distingush?

Answer 31

11:22 translocation

Question 32

chondroma

Answer 32

benign tumor of cartilage, usually arises in the small bones of the hands and feet

Question 33

chondrosarcoma

Answer 33

malignant cartilage forming tumor, arises in the medullar of the pelvis or central skeletan

Question 34

metastatic tumors

Answer 34

more cmomon than primary

usualy result in osteolytic (punched out lesions)
- exception is that prostate carcinoma clasically produces osteoblastic lesions (sclerosis of bone)