immuno pharm Flashcards by John-Paul Cathcart Jr.

Q

immunosuppresants basics: general action?

A

block lymphocyte activation and proliferation

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Q

immunosuppresants basics: use

A

reduce acute transplant rejection by supressing cellular immunity (used as prophylaxis)

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Q

immunosuppresants basics: why combine?

A

increase efficacy and decrease toxicity

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Q

immunosuppresants basics: increased risk for?

A

infection and malignancy

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Q

cyclosporine mec

A

116

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Q

cyclosporine use

A

116

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Q

cyclosporine toxicity

A

hyperkalemia, hyperglycemia

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Q

tacrolimus (fk506) mech

A

116

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Q

tacrolimus (fk506) toxicity

A

116

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Q

tacrolimus (fk506)

A

116

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Q

cyclosproine and tacrolimus pharmacology

A

cyp p450 metabolism

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Q

sirolimus (rapamycin) mech

A

116

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Q

sirolimus (rapamycin) use

A

116

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Q

sirolimus (rapamycin) toxicity

A

116

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Q

sirolimus (rapamycin) notes

A

116

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Q

basiliximab mech

A

116

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Q

basiliximab use

A

116

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Q

basiliximab effects

A

116

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Q

azathioprine mech

A

116

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Q

azathioprine use

A

116

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Q

azathioprine toxicity

A

116

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Q

azathioprine notes

A

116

Q

mycophenolate mofetil mech

A

116

Q

mycophenolate mofetil use

A

116

Q

mycophenolate mofetil toxicity

A

116

Q

mycophenolate mofetil notes

A

116

Q

corticosteroids mech

A

116116

Q

corticosteroids uses

A

116

Q

corticosteroids effects

A

116

Q

corticosteroids notes

A

116

Q

Aldesleukin

A

117

Q

epoetin alfa

A

117

Q

filgrastim

A

117

Q

sargramostin

A

117

Q

ifn alpha

A

117

Q

ifn b

A

117

Q

ifn g

A

117

Q

romiplostim

A

117

Q

eltrombopag

A

117

Q

oprelvekin

A

117

Q

alemtuzumab target, clinical use,

A

118

Q

bevacizumab target, clinical use,

A

118

Q

cetuximab target, clinical use,

A

118

Q

rituxumab target, clinical use,

A

118

Q

trastuzumab target, clinical use, notes

A

118

Q

daclizumab target, clinical use,

A

118

Q

eculizumab target, clinical use,

A

118

Q

natalizumab target, clinical use, notes

A

118

Q

ustekinumab target, clinical use,

A

118

Q

abciximab target, clinical use,

A

118

Q

denosumab target, clinical use,

A

118

Q

ranibizumab target, clinical use,

A

118

Q

bevacizumab extra use

A

118