micro pharm Flashcards
penicillin G route of administration?
183
Pevcillin V route of administration?
183
pencillin analg of?
183
pencillin mechanism
183
pencillin prevents?
183
pencillin use?
183
pencillin bactericidal for who?
183
pencillin sensitive too?
183
pencillin adverse effects
183
pencillin resistance
183
pencillinase sensitive penicillins names
184
pencillinase sensitive penicillins combine with?
184
amoxicillin better than apmpicillin how?
184
pencillinase sensitive penicillins use
184
pencillinase sensitive penicillins effects
184
pencillinase sensitive penicillins resistance
184
why is MRSA resistant to staph penicillins?
because altered binding proteins
pencillinase sensitive penicillins resistance
184
penicillinase resistant penicilins names
184
penicillinase resistant penicilins mech
184
penicillinase resistant penicilins use
184
penicillinase resistant penicilins adverse
184
antipseudomonal penicillins names
184
antipseudomonal penicillins mech
184
antipseudomonal penicillins use
184
antipseudomonal penicillins adverse effects
184
antibiotics with anaerobic activity
clindamycin, metronidazole, augmentin, ticaercillin-clavulatante, pipericillin-tazobactam, carbepenems, moxifloxican, tigecycline
antipseudomonal penicillins adverse effects
184
piperacillin-tazobactam good for?
184
name the b lactamse inhibitors
184
cephalosporins mech
185
cephalosporins orgnisms not covered
185
cephalosporins 1st gen
185
cephalosporins 2nd gen
185
cephalosporins 3rd
185
cephalosporins 4th
185
cephalosporins 5th
185
cephalosporins 5th
185
uworld describes anaphlaxis, what were they taking, DOC to treat?
ceftrixaone (b lactam allergic)
epinephrine, then later steroid and antihistamines
ceftraxone works agaisnt?
h influ
kleb pneumonia
neisseria
serratia
what carbapenem does not work agaisnt pseudomonas?
ertapenem
carbapenem mech
186
carbapenem use
186
carbapenem adverse
186
carbapenem doc for
186
carbapenem doc for
186
monobactam names
186
monobactam mech
186
monobactam benefit
186
monobactam actions agaisnt (important)
186
monobactam use
186
monobactam adverse affects
186
vancomycin action
186
vancomycin bactericidial vs bacertiostatic
186
vancomycin not susceptible to?
186
vancomycin 1st line agaisnt?
186
vancomycin use
186
vancomycin effects
186
vancomycin mechanism of resistance
186
bactericidal protein synthesis inhibitor
aminoglycoside
bactericidal protein synthesis inhibitor etc
aminoglycoside, the rest are static except linezolid which is variable
aminioglycosides names
188
aminoglycosides imortant coverage
188
aminioglycoside mech
187
aminioglycoside clinical use
188
aminioglycoside clinical use
187
aminioglycoside adverse effect
187
aminioglycoside resistance
187
tetracyclines names
tetracyclins, doxycycline, minocycline
tetracycline with improtant coverage
doxyxyline
what not to take wiht?
kaplan said al too
tetracycline mech and penetration
188
tetracycline safe in renal failure?
188
tetracycline use
188
tetracycline adverse effects
188
tetracycline resistance
188
tetracycline resistance
188
tigecycline use
188
tigecycline effects
188
chloramphenicol mech
188
chloramphenicol use
188
chloramphenicol effects
188
chloramphenicol resistance
188
clindamycin improtant coverage mrsa
188
clindamcin mechanism
188
clindamcin use
188
clindamcin effects
188
oxazolidinones 2nd line for what?
mrsa, 1st line vancomycin
oxazolidinones mech
189
oxazolidinones use
189
oxazolidinones effects
189
oxazolidinones resistance
189
macrolide names
189
macrolide that doesnt inhibit cyp
189
macrolide mech
189
macrolide use
189
macrolide effects
189
macrolide resistance
189
urethritis treat with
ceftriaxone + doxycyline or macrolide
tmp-smx important coverage
190
sulfonamides names
190
sulfonamides mech
190
sulfonamides use
190
dapsone mech
190
sulfonamides effects
190
sulfonamides resistance
190
dapsone use
190
dapsone effects
190
trimethoprim
190
pyremethamine mech
190
trimpethoprim use
190
trimpethoprim useeffects
190
tmp smx in pregancy
190
alternative to UTi with tmo smx
nitrofurantoin
moxifloxacin works agiasnt?
anerobes
fluroquinolone without -floxacin in the name
enoxacin
fluroquinolone mech
191
fluroquinolone dont take with?
191
fluroquinolone use
191
fluroquinolone effects
191
fluroquinolone resistance
191
daptopmycin mech
191
daptopmycin use
191
daptopmycin resistance
191
daptopmycin effects
191
metronidazole mech
191
metrionidazole effects
191
MAC prophylaxis
192
MAC treatment
192
rafamycins names
192
rafamycins mech
192
rafamycins use
192
rafamycins affects
192
rafamycins resistance
192
isonizaid mech
193
isonizaid isonizaid use
193
isonizaid pharmacology
193
isonizaid affects
193
isonizaid resistance
193
isonizaid resistance
193
pyrazinamide mech
193
pyrazinamide side effect
193
ehtambutol mech
193
ehtambutol effects
193
streptomycin TB
193
streptomycin use
193
streptomycin tinnitus vertigo aaxia neprotocitcity
193
high risk endocarditis dental procedure
amoxicillin
expsoure to goorrhea
cetriaxone
histoyr of reccurent uti?
tmp smx
expsoure to meningicoccal infection
ceftriaxone, ciprofloxacin, rifampin
treatment of pregger with group b strep
intrapartum penicillin g or ampicillin
prevention of gonoccal conjuctivitis in newborn
erythromycin
postsurgical infection due to staph aureus
cafazolin
propylaxis of strep pharygitis in child with prior rheumatic fever
benazathine penicillin g or or oral penicillin v
syphilliz exposure
benzathing penicillin g
ampthoterricin B mech
195
ampthoterricin B use
195
ampthoterricin B why do you get the side effects
195
nystatin mech
195
nystatin use
195
flucytosine mech
195
flucytosine use
195
flucytosine side effct
195
flucytosine side effct
195
fluconazole used for?
195
itraconazole for
195
topical fungal infections
195
voriconazole used for?
195
isavuconazole used for?
195
azoles effects
195
terbinafine mech
blocks conersion of squalene to squalene epoxide by blocking squalene epoxidase
terbinafine use
195
terbinafine side effects
195
echindodins suffix
196
echindodins mech
196
echindodins use
196
echindodins effects
196
echindodins effects
196
griseofulvin mech
196
griseofulvin use
196
griseofulvin effects
196
suffix for flu drugs
–amivir
flu grus mech
197
flu grus use
197
-virs mech
197
-virs use
197
-virs for herpes zoster (shingles)
197
virs side effects
197
virs resistance
197
virs u world side effects
197
gangciclovir mech
198
gangciclovir use
198
gangciclovir side effcts
198
gangciclovir resistance
198
foscarnet mech
198
foscarnet use
198
foscarnet effects
198
foscarnet resistance
198
cidofovir mech
198
cidofovir use
198
cidofovir effects
198
indication for hiv therapy
199
preferred treatment for HIV
199
nrti suffix
-vudine
nrti mech
199
zidovudine special use
199
nrtis
effects
nnrtis names
199
nnrtis mech
199
nnertis effects
199
protease inhibitor suffix
199
protease inhibitor mech
199
protease inhibitor booster
199
protease inhibitor pharmaclogicy
199
protease inhibitor effects
199
integrase inhibitor common nae
-tegr-
integrase inhibitor mech and side effects
mec
fusion inhbitor name
199
fusion inhbitor mech
199
fusion inhbitor effects
199
docking inhibitor name and mech
199
interferons mech
200
ifn a use
200
ifn b use
200
ifn f
200
interferons efftcs
200
ribavarin mech
200
ribavarin use
200
ribavarin effects
200
sofosbuvir mech
200
sofosbuvir use
200
sofosbuvir effects
200
simeprevir mech
200
simeprevir use
200
simeprevir effects
200
antimicrobials to avoid in pregancy
201
cd4 less than 200 prophylaxis
use tmp smx for pneumocystis
cd4 less than 100 prohylaxis
tmp and smx for pneumocystis and toxoplasmosis
cd4 less than 50 prophylaxis
use azithromycin or clarithromycin for MAC
mrsa treatment
vancomycin, daptomycin, linezolid, tigecycline, cefaroline, doxycycline
vre treatment
linezolid, streptogamins (quinupristin, dalfopristin) - bind to 50s, i added (daptomycin, linezolid, tigecycline
multidrug resistant p aeruginosa
polymixins B and E(colistin)
multidrug resistant acinetobacter baumannii
polymixins B and E(colistin)
azole for histoplasma, coccidioides, blastomyces
itraconazole
topical azole for fungal infections of skin
coltrimazole and miconazole
asperigillus infection
voriconazole (also works agaisnt some candida)
serious aspergillus use isavuconazole
mucorales infection
amphoterricin
isavuconazole
toxoplasmosis treatment
pyrimethamine + sulfadiazine
t cruzi
benznidazole or nifurtimox; crusing in my benz with a fur coat on
leshminiasis
amphotericin b (localized cutaneous) or sodium stibogluconate (sever diffuse cutaneous and visceral)
antimite/louse therapy
permethrin (neuronal membrane deplorization via na channels)
malathion (acetylcholinesterase inhibitor)
lindane (blocks gaba channels -> neurotoxicity)
used to treat scabies (sarco scabiei) and live (pediculus and pthirus)
treat Pesky Mites and Lice with PML because they NAG you
scabies: permethin cream, washing/drying all clothing/bedding, treat close contacts
lice: pyrethoids, malathion, or ivermectin lotion, and nit combing. children can attend school and treated at home
malaria treatments
use choloroquine for sensitive species (dont use for falciparum, resistance too common)
if resistant use:
mefloquine, atovaquone/proguanil
Treat falciparum with:
artemether/lumefantrine or atovaquone/proguanil
for life threatening use:
use IV quinidine in US (quinine elsewhere) or artesunate
for p vivax/ovale
add primaquine for hypnozoite
chloroquine (hydrozychloroquine)
blocks plasmodium heme polymerase which turns heme into hemozoin. heme accumulates and is toxic.
resistance due to membrane pump that reduces intracellular concentrations
retinopathy; pruitis (especially in dark skinned people)
empiric meningitis treatment
ceftriaxone and vancomycin (add ampicillin if listeria suspected)
emtricitabine (ftc)
nrti macular rash on palms
c tetani treatment
prevent with vaccine. treat with antitoxin plus minus vaccine booster., diazepem (for muscle spasms), wound debridement.
c diff treatment
often caused by clindamycin, ampicillin, associated with ppi use.
metronidazole or oral vancomycine. reccurent cases consider fidaxomicin, or fecal microbiota transplant.
listeria monocytogenes treatment
ampicillin
gonocci treatment
cetriaxone + (azithromycin or doxycyline) for chlamydia
erythromycin oitment prevents neonatal blindness
menigocci treatment
rifampin, ciprofloxacin, ceftriaxone for prophylaxis of close contacts.
treat with ceftriaxone or penicillin g
haemophilus influenza treatment
amoxicillin +/- claculanate for mucosal infections. ceftriaxone for meningitis. rifampin prophylaxis for close ocntacts.
legionella treatment
macrolide or quinolone
pseudomonas treatment treatment
“campfire”
carbapenems
aminoglycosides
monobactams
polymyxins (polymixn b, colistin)
fluroquinolones (ciprofloxacin, levofluroquinolone)
thIRd and fourth gen cepahlospoins (eg ceftazidime, cefepime)
extended spectrum peniciilins (eg ticarcillin, piperacillin)
salmonella typhi
ceftriaxone or fluroquinolones
h pylori
amoxicillin (metronidazole if allergic) + clarythromycin + ppi (antibiotics cure pylori)
lyme disease
doxycyline (1st line); amoxicillin and cefuroxime in pregnant women and children
utd says all work for early stage
g vaginalis
metro or clindamycin
chlamydiae
treatment: azithromycin (prefered because one time treatment) or doxycyline (+ceftriaxone)
lacks classic peptidoglycan due to reducde muramic acid so b lactams dont work
m pneumonia
macrolides, doxycyline, or fluroquinionlens.
penicillin infeective since no cell wall
candida
oral fluconazole/topical azole for vaginal.
nystatin, fluconazole, or capsofungin for oral/esophageal.
fluconazole, caspofungin, or amphoterricin b for systemic
c neoformans
amphoterricin b + flucytosine followed by fluconzaole for meningitis
mucor and rhizopus
surgical debridement and amphoterricin b
PCP
tmp-smx, pentamidine (if sulfa allergy), dapsone (prophylaxis only), atovaquone. Start prophylaxis when cd4 less than 200
sporothrix
itraconazole or k iodide
giardia
metro
e histolytica
metronidazole; paromomycin or iodoquinol for asymptomatic stool passers
cryptosporidium
prevention by filtering city water supplies; nitazoxanide in immunocmopetent hosts
toxoplasmosis
tmp smx prophylaxis
sulfadiazine + pyrimethamine
n fowleri
amphoterrin b has been effective in a few
t brucei
suramin for blood
melarsoprol for CNS
babesia
atovaquone + azithromycin
t cruzi
benznidazole or nifurtomox
curising in my benz with my fur coat
l donovani
amphoterricn b (localized cutaneous)
sodium stibogluconate (severe diffuse cutaneous or visceral)
t vaginalis
metronidazole for patient and partner (prophylaxis)
enterobius vermiculuari (pin worm)
bendazoles (1st line)
pyrantel pamoate (pregnant)
ascaris (giant roundworm)
bendazoles
strongyloides (threadworm)
ivermectin or bendazoles
ancyclostome/necator (hookworms)
bendazoles or pyrantel pamoate
t spiralis
bendazoles
trichuris trichiura (whipworm)
bendazoles
toxocara canis
bendazoles
onchocerca volvulus
ivermectin
loa loa
diethylcarbamazine
wuchereria bancrofti
diethylcarbamazine
t solium
intestinal tapeworm - paziquantel
cystercercosis - praziquantel
neurocystercerci - albendazole
d latum
praziquantel
e granulosis
albendazole
schistoma
praziquantel
clonorchis
praziquantel
rsv prophylaxis in premies
palivizumab
postexposure prohylazin rabies
wound cleaning plus immunization with killed vaccine and rabies immunoglobin
