MSK pharm Flashcards
glucocorticoid (corticosteroid) with strange name
triamcinolone
corticosteroid highlighted action
increase kB which inhibits NF-kB (nuclear transcription factor) which upregulates cox2
tnf a controls nfkb
also inhibits phospholipase a2, which frees arachadonic acid from membrane phospholipids
what coxs are important in the kidney?
cox 1 and 2
where is cox 1?
- kidney
- gi
- platelets
- endothelium
where is cox 2?
- inflammatory cells
- endothelial cells
- kidney
cox 2 makes prostaglandins that are important for?
permeability, pain, fever
leukotriences that increase bronchial tone
LTC4, LTD4, LTE4
leukotrience that attracts neutrophils
LTB4
pgi2
decrease platelet aggregation and vascular tone
txa2
increase platelet aggregation, increase vascular tone
pge2 actions
redness: vasodilation
edema: permeability
fever: hypothalamus
pain: nerves
what can causes acute kidney injry?
uptodate says any class of nsaid
acetaminophen mech
455
acetaminophen use
455
acetaminophen effcts
455
aspirin pharmacology
o order at high/toxic concentration
aspirin can causes CIN and renal papillary necrosis how?
combined with acetomenophin
how to treat aspirin OD
nahco3, it alkalnizes the urine
aspirin mech
456
aspirin effects
aspirin induced asthma, less frequently causes AIN then the other NSAIDS,
celecoxib mech
456
celecoxib use
456
celecoxib effects
456
celecoxib effects
456
nsaids names
456
nsaids mech
456
nsaids use
456
nsaids effects
456
leflunomide mech
456
leflunomide use
456
leflunomide effects
456
bisphosphonates suffix
456
bisphosphonates mech
456
bisphosphonates use
1st line for osteoporosis
bisphosphonates effects
456
teriparatide mech
457
teriparatide use
457
teriparatide effects
457
chart of purine break down
457
allopurinol
457
febuxostat
457
pegloticase
457
probenecid
457
acute gout treatment, priority
nsaids, colchicine, glucocorticoids
nsaids for gout
457
colchcine
457
tnf alpha inhibitors predispose too?
457
etanercept use
457
etanercept mech
457
infliximab, adalimumab, certolizumab, golimumab mech
457
infliximab, adalimumab, certolizumab, golimumab use
457
1st line treatment for osteoporosis
bisphosphanates, calcium and vit d also recommended
2nd treatments for osteoporosis
raloxifene, denosumab (MAB agaisnt RANKL), teriparatide, caclitonin (rarely)
calcitonin uses and mech
inhibits osteoclastic resorption, used in hypercalcemia and pagets
drugs for neuropathic pain review
458
