MSK pharm

Question 1

glucocorticoid (corticosteroid) with strange name

Answer 1

triamcinolone

Question 2

corticosteroid highlighted action

Answer 2

increase kB which inhibits NF-kB (nuclear transcription factor) which upregulates cox2

tnf a controls nfkb

also inhibits phospholipase a2, which frees arachadonic acid from membrane phospholipids

Question 3

what coxs are important in the kidney?

Answer 3

cox 1 and 2

Question 4

where is cox 1?

Answer 4

• kidney
• gi
• platelets
• endothelium

Question 5

where is cox 2?

Answer 5

• inflammatory cells
• endothelial cells
• kidney

Question 6

cox 2 makes prostaglandins that are important for?

Answer 6

permeability, pain, fever

Question 7

leukotriences that increase bronchial tone

Answer 7

LTC4, LTD4, LTE4

Question 8

leukotrience that attracts neutrophils

Answer 8

LTB4

Question 9

pgi2

Answer 9

decrease platelet aggregation and vascular tone

Question 10

txa2

Answer 10

increase platelet aggregation, increase vascular tone

Question 11

pge2 actions

Answer 11

redness: vasodilation
edema: permeability
fever: hypothalamus
pain: nerves

Question 12

what can causes acute kidney injry?

Answer 12

uptodate says any class of nsaid

Question 13

acetaminophen mech

Answer 13

455

Question 14

acetaminophen use

Answer 14

455

Question 15

acetaminophen effcts

Answer 15

455

Question 16

aspirin pharmacology

Answer 16

o order at high/toxic concentration

Question 17

aspirin can causes CIN and renal papillary necrosis how?

Answer 17

combined with acetomenophin

Question 18

how to treat aspirin OD

Answer 18

nahco3, it alkalnizes the urine

Question 19

aspirin mech

Answer 19

456

Question 20

aspirin effects

Answer 20

aspirin induced asthma, less frequently causes AIN then the other NSAIDS,

Question 21

celecoxib mech

Answer 21

456

Question 22

celecoxib use

Answer 22

456

Question 23

celecoxib effects

Answer 23

456

Question 24

celecoxib effects

Answer 24

456

Question 25

nsaids names

Answer 25

456

Question 26

nsaids mech

Answer 26

456

Question 27

nsaids use

Answer 27

456

Question 28

nsaids effects

Answer 28

456

Question 29

leflunomide mech

Answer 29

456

Question 30

leflunomide use

Answer 30

456

Question 31

leflunomide effects

Answer 31

456

Question 32

bisphosphonates suffix

Answer 32

456

Question 33

bisphosphonates mech

Answer 33

456

Question 34

bisphosphonates use

Answer 34

1st line for osteoporosis

Question 35

bisphosphonates effects

Answer 35

456

Question 36

teriparatide mech

Answer 36

457

Question 37

teriparatide use

Answer 37

457

Question 38

teriparatide effects

Answer 38

457

Question 39

chart of purine break down

Answer 39

457

Question 40

allopurinol

Answer 40

457

Question 41

febuxostat

Answer 41

457

Question 42

pegloticase

Answer 42

457

Question 43

probenecid

Answer 43

457

Question 44

acute gout treatment, priority

Answer 44

nsaids, colchicine, glucocorticoids

Question 45

nsaids for gout

Answer 45

457

Question 46

colchcine

Answer 46

457

Question 47

tnf alpha inhibitors predispose too?

Answer 47

457

Question 48

etanercept use

Answer 48

457

Question 49

etanercept mech

Answer 49

457

Question 50

infliximab, adalimumab, certolizumab, golimumab mech

Answer 50

457

Question 51

infliximab, adalimumab, certolizumab, golimumab use

Answer 51

457

Question 52

1st line treatment for osteoporosis

Answer 52

bisphosphanates, calcium and vit d also recommended

Question 53

2nd treatments for osteoporosis

Answer 53

raloxifene, denosumab (MAB agaisnt RANKL), teriparatide, caclitonin (rarely)

Question 54

calcitonin uses and mech

Answer 54

inhibits osteoclastic resorption, used in hypercalcemia and pagets

Question 55

drugs for neuropathic pain review

Answer 55

458