Tuberculosis: Treatment and prevention 4

Question 1

List the 4 Tb chemoprophylaxs regimens

Answer 1

3HP 3 months of weekly isoniazid PLUS rifapentine
3RH 3 months of daily rifampicin PLUS isoniazid
6H 6 months of daily isoniazid
12H 12 months of daily isoniazid

Question 2

Symptoms screen for TB chemoprophylaxis regimens

Answer 2

HIV+
* Cough (any duration)
* Fever
* Unexplained weight loss
* Night sweats
* History of previous TB
* Adherence to ART

Question 3

List the adverse effects for Rifapentine

Answer 3

Rifapentine: Hepatotoxicity, GI, Hypersensitivity after first 3-4 doses (flu-like symptoms, fever, headache,
dizziness, SOB, wheezing, muscle and bone pain, rash, itching, red eyes, hypotension or shock) – if mild
manage side-effects, if severe discontinue treatment and refer to hospital.