Drugs for dyslipidaemias Flashcards
List the complications of atherosclerosis
cerebral infarction
Gangrene
Peripheral vascular disease with intermittent claudication
Aortic aneurysms-rupture causes sudden death
Mycocardial infarction, cardiac failure
Carotid atheroma-emboli causing transient ischaemic attacks or cerebral infarcts
what types of lipids are in the blood?
LDL
HDL
Triglycerides
Total cholesterol
Explain the primary dyslipidaemia
Primary forms are genetically determined
Familial hypercholesterolaemia
explain the secondary Dyslipidaemia and list the examples
2 degree forms are consequences of other conditions/drugs
Typer 2 diabetes mellitus
Obesity
Alcoholism
Nephrotic syndrome’Chronic renal failure’Hypothyroidism
Liver disease and Drugs=isotetrinoin and protease inhibitors (!HIV tx)
list drug that are HMG CoA reductase inhibitors (statins)
Atorvastatin
Simvastatin
Rosuvastatin
name drugs that are bile acid sequestrants
Cholestyramine
Name the drugs that are nicotinic acid and derivates
Acipomox, nicotinic acid
Name drugs that are fibrates
Bezafibrates, fenofibrate, gemfibrozil
List drugs that are inhibitors of cholesterol absorption
Ezetimibe
MoA of bile acid binding resins
Increase LDL catabolism, Decrease cholesterol absorption
effect on lipids of bile acid binding resins
decrease LDL
MoA of nicotinic acid
decrease LDL and VLDL synthesis
effects on lipids of nicotinic acid
Decrease TG, VLDL, LDL
Increase in HDL
MoA of fibrates
Increase in VLDL clearance, decrease VLDL synthesis
effects on lipids of fibrates
↓ TG ,↓ VLDL,↓LDL, ↑ HDL