Drugs for abdominal pain Flashcards
The functional bowel disorder of the GIT associated with what?
- Abdominal pain
- Altered bowel activity
- Lacking any pathological changes
Synonyms for IBS
Spasti colon
Irritable colon
List the subclassifications for IBS
IBS-D: IBS with predominant diarrhoea
* IBS-C: IBS with predominant constipation
* IBS-M: IBS with alternating constipation & diarrhoea
List the aetiology for IBS
- Multifactorial cause (not sure)
- Motility dysfunction
- Diet
- Genetics
- Psychological factors (stress /
depression)
Explain the treatment approach for IBS
Depend on symptom representation
* Co-morbid conditions, such as lifestyle, diet and stress disorders
* Focus on normalising GI motility
IBS stand for what?
Irritable bowel syndrome
List the agents affecting the GI motility
Antispasmodics
(Antimuscarinic / anticholinergic)
* Dicycloverine
* Mebeverine
* Propantheline
* Hyosine*
! Reduce GI motility
Motility stimulants (propulsives):
mainly IBS-C
enhance gastric emptying, decrease small bowel transit time & increase gastro-oesophageal sphincter tone
Role in IBS not defined
* Metoclopramide
* Domperidone
List the antispasmodic drugs
Hyoscine
Mebeverine
Dicycloverine
MoA for Hyoscine
Hyoscine
Buscopan®, Hyospasmol®, Scopex® = competitively antagonises Ach activity at muscarinic receptors in
GI, biliary and genitourinary tracts
SE for Hyoscine
Constipation and dry mouth
DI for Hyoscine
TCA, neuroleptics, antihistamines
CI for Hyoscine
Glaucoma, myasthenia gravis and prostate enlargement
Avoid hyoscine for which patients
Pregnancy and lactation
MoA for Mebeverine
Mebeverine
Colofac®, Bevispas® = selectively relaxes smooth muscle in GIT via anticholinergic action
SE for mebeverine
diarrhoea
Constipation
Dizzness
