Drugs for heart failure 3

Question 1

Explain contra-indication for Digoxin

Answer 1

Ventricular arrythmias without HF, Wolf-Parkinson-White syndrome, hypertrophic obstructive cardiomyopathy, incomplete AV nodal block

Question 2

Drug interaction for Digoxin

Answer 2

Drug interactions
* Agents affecting digoxin metabolism
* Depressants of AV node
* Agents affecting potassium levels
* Agent affecting absorption from GIT

Question 3

Summary treatment of HFrEF (Heart Failure with reduced Ejection Fraction)
List the cornerstone for treatment

Answer 3

Cornerstone of treatment:
* B-blockers, ACEI/ARBs & mineralocorticoid (aldosterone) receptor antagonists

Question 4

Summary treatment of HFrEF (Heart Failure with reduced Ejection Fraction)
List the Additional benefits

Answer 4

Additional benefit:
* SGLT2 inhibitors & angiotensin receptor / neprilysin inhibitors

Question 5

Summary treatment of HFrEF (Heart Failure with reduced Ejection Fraction)
List the other adjunctive agents:

Answer 5

Other adjunctive agents:
* Nitrate/hydralazine combination, digoxin, ivabradine

Question 6

For congestion uses what?

Answer 6

Diuretics

Question 7

The use of hydralizine/nitrates improve what?

Answer 7

Improves the composite endpoint of mortality, hospitalizations for HF, and quality of life in Black patients receiving guidelines -directed medical therapy (GDMT) for HFrEF.

Question 8

Hydralazine and nitrates should be used in which group of patients

Answer 8

Hydralazine and nitrates should be used in Black patients with persistent symptoms despite GDMT.

Question 9

Hydralazine and nitrate might be reasonable to which patients

Answer 9

Hydralazine and a nitrate might be reasonable in patients unable to tolerate either an ACE inhibitor or ARB because of renal insufficiency, hyperkalemia, or possibly hypotension.