Introduction to drugs affecting the cardiovascular system Flashcards
List the alpha 1 blocking agents
Doxazosin
Prazosin
Terazosin
List the indications for alpha-1 blocking agents
- Hypertension 4th line (NOT monotherapy)
- Pheochromocytoma-associated hypertension
- Benign prostatic hypertrophy (BPH)
How is the formulation of alpha-1blocking drugs
Use controlled-released formulation (daily dose)
Explain the pks of alpha-1 blocking agents
Extensively metabolized in the liver and excreted mainly as metabolites in the faeces
Explain the contra-indications of Alpha-1 blocking agents
Contraindication: hypersensitivity
For controlled-release tablets: history of GI obstruction, oesophageal
obstruction, decreased lumen diameter of GIT
Caution for alpha-1 blocking agents
Hepatic impairment
List the adverse effects of alpha-1 blocking agents
First dose hypotension, hypotension, dizziness, vertigo, headache, fatigue
* Orthostatic hypotension, palpitations, nausea etc.
Function of RAAS
Coordinate renal and
cardiovascular functions
* Homeostatic control of blood
volume
* Electrolyte balance
* Vascular resistance
Name the proteolytic enzyme
Renin
where is Renin stored
- Stored in juxtaglomerular cells in
kidneys
When is Renin released
Released; response to sympathetic
activation of B1 receptors, systemic
hypotension, decreased tubular Na+
what is the function of renin
↓ arterial pressure = ↓ renal
perfusion + baroreflex mediated
sympathetic activation of renal β1
induce release of renin
Name the mineralocorticoid
Aldosterone
Function of aldosterone
Increase sodium reabsorption
(promote sodium retention)
The posterior pituitary peptide hormone also known as vasopressin
ADH
