Introduction to drugs affecting the cardiovascular system 1 Flashcards
List the cardiovascular diseases
affecting the heart and blood vessels
- Hypertension
- Atherosclerosis
- Ischaemic heart disease
- Heart failure
- Arrythmias
The most prominent risk factor contributing to the prevalence of cardiovascular disease
Hypertension
List the 7 cardiovascular drug classification: SAMF
- Cardiac therapy
- Antihypertensives
- Diuretics
- Beta-blocking agents
- Calcium-channel blockers
- Agents acting on renin-angiotensin system
- Serum lipid modifying agents
For cardiac therapy list drugs classes acting on the heart
Acting on the heart
* Cardiac glycosides
* Antiarrhythmics
* Cardiac stimulants
* Vasodilators (cardiac disease)
* Other
List the non selective (b1 and b1)
Propranolol
Sotalol
Timolol
The non selective beta blocking are contra-indicated for which respiratory condition
Asthma
List the drugs for B1 selective
Atenolol
Bisoprolol
Esmolol
Metoprolol
Nebivolol
what are the comments about B1 selective blocking agents
Cardio-selective
preferred in angina
List the drugs that are vasodilatory non-B1 selective
Carvedilol (+a1-blocker)
Labetalol (+NO vasodilatory effect)
The Vasodilatory non B1 selective is preferred in which condition
Preferred in CCF
List the 5 indications for beta-blocking agents
Angina pectoris (β1-selective)
Acute coronary syndrome / acute MI
Arrhythmias
Congestive cardiac failure (Vasodilatory non-β1-selective)
(Hypertension (β1-selective) 5th line agent)
List the other indication (Non-selective agents)
4 marks
Other indications (Non-selective agents)
* Essential tremor
* Symptomatic anxiety
* Adjunct in thyrotoxicosis
* Migraine prophylaxis
List the drugs that are lipid soluble
Propranolol
Metoprolol
Labetalol
List drugs that are least lipid soluble
Atenolol, sotalol
The least lipid soluble drugs are having fewer side effect to which system
CNS
List the 6 beta blocking agents: side effects
Bradycardia
Bronchospasm
Masking hypoglycaemia
Fatigue
Cold extremities
Cholesterol dysregulation
CNS effects that are caused by lipid soluble
Insomnia and depression
The long terms studies in hypertension, the uses of which drugs that causes MD2 and less protection from stroke
Atenolol and thiazide diuretics
The use atenolol with thiazide diuretics suggest increased risk of what?
Type 2 DM
Less proctection from stroke
Contra-indications/caution of beta blocking agents
Asthma and COPD
Heart block
DM
Depression (non-selective)
