Tuberculosis Drugs Flashcards
1
Q
What is the mechanism of action of rifampicin?
A
Inhibits bacterial DNA dependent RNA polymerase
2
Q
What are some side effects of rifampicin?
A
- Hepatitis
- Orange secretions (sweat etc.)
- Flu-like symptoms
- Liver enzyme enducer
3
Q
What is the mechanism of action of isoniazid?
A
It inhibits mycoclic acid synthesis
4
Q
What are some side effects of isoniazid?
A
- Peripheral neuropathy
- Hepatitis
- Agranulocytosis
- Liver enzyme inhibitor
5
Q
What is the mechanism of action of pyrazinamide?
A
It is converted by pyrazinamidase into pyrazinoic acid which in turn inhibits fatty acid synthase (FAS) 1
6
Q
What are some side effects of pyrazinamide?
A
- Hyperuricaemia causing gout
- Arthralgia, myalgia
- Hepatitis
7
Q
What are some side effects of ethambutol?
A
- Optic neuritis.
- Dose needs adjusting in renal impairment.
8
Q
How does ethambutol work?
A
It inhibits the enzyme arabinosyl transferase which polymerizes arabinose into arabinan
