Thiazide diuretics

Question 1

How do thiazide diuretics work?

Answer 1

1. They inhibit sodium reabsorption at the beginning of the distal convoluted tubule.
2. More sodium gets through to the collecting ducts
3. Potassium is lost as a result.

Question 2

What are some common adverse effects of thiazide diuretics?

Answer 2

• Dehydration
• Postural hypotension
• Hyponatraemia, Hypokalaemia, hypercalcaemi
• Gout
• Impaired glucose tolerance
• Impotence

Question 3

What are some rare adverse side effects?

Answer 3

• Thrombocytopaenia
• Agranulocytosis
• Photosensitivity rash
• Pancreatitis

Question 4

Where do thiazide diuretics fit in the hypertension managemeent guidelines?

Answer 4