DOACs Flashcards
What is the UK brand name of dabigratran?
Pradaxa
What is the UK brand name of Rivaroxaban?
Xarelto
What is the UK brand name of apixaban?
Eliquis
What is the mechanism of action of dabigatran?
Direct thrombin inhibitor
What is the MOA of Rivaroxaban?
Direct factor Xa inhibitor
What is the MOA of Apixaban?
Direct factor Xa inhibitor
How id dabigatran excreted?
Mostly renal
How is rivaroxaban exreted?
Mostly Liver
How is apixaban exreted?
Mostly faecal
What are the NICE indications of treatment using dabigatran?
- Prevention of VTE following hip/knee surgery
- Prevention of stroke in non-valvular AF with co-morbidities:
- Prior stroke or TIA, Age >=75 years, HTN, DM, HF.
What are the NICE indications of treatment using Rivaroxaban?
- Prevention of VTE following hip/knee surgery
- Treatment of DVT and PE
- Prevention of stroke in non-valvular AF with co-morbidities:
- Prior stroke or TIA, Age >=75 years, HTN, DM, HF.
What are the NICE indications of treatment using Apixaban?
- Prevention of VTE following hip/knee surgery
- Prevention of stroke in non-valvular AF with co-morbidities:
- Prior stroke or TIA, Age >=75 years, HTN, DM, HF.
Describe the coagulation cascade & where oral anticoagulants fit in it?
What is considered to be the safer DOAC?
Apixaban (but probably due to the short half life)
What eGFR is Dabigatran not recommended in?
<30ml/min