Ciclosporin Flashcards
1
Q
With is the MOA of ciclopsorin?
A
It decreases T cell proliferation.
2
Q
What are the adverse effects of ciclopsorin?
A
- Nephrotoxicity
- Hepatotoxicity
- Fluid retention
- Hypertension
- Hyperkalaemia
- Hypertrichosis
- Gingival hyperplasia
- Tremor
- Impaired glucose tolerance
- Hyperlipidaemia
- Increased susceptibility to severe infection
3
Q
What is a way to remember the side effects of ciclosporin?
A
It increases EVERYTHING - K+, hair, fluid, BP, gums, glucose.
4
Q
What is the interesting thing about ciclosporin compared to other immunospuressants?
A
It is non-myelotoxic.
Other immunosuppresants usually are.
5
Q
What is ciclosporin indicated in?
A
- Organ transplantation
- RA
- Psoriasis
- UC
- Pure red cell aplasia
