Drug-induced Liver Disease Flashcards
1
Q
What categories is drug-induced liver disease divided into?
A
Cholestatic, Hepatocellular or Mixed
2
Q
What drugs tend to cause a hepatocellular picture?
A
- Paracetamol
- Sodium valproate, phenytoin
- MAOIs
- Halothane
- Anti-tuberculosis: isoniazid, rifampicin, pyrazinamide
- Statins
- Alcohol
- Amiodarone
- Methyldopa
- Nitrofurantoin
3
Q
What drug tend to cause a cholestatic or mixed picture?
A
- Oral contraceptive pill
- Antibiotics: flucloxacillin, co-amoxiclav
- Anabolic steroids, testosterones
- Phenothiazines: chlorpromazine, prochlorperazine
- Sulphonylureas
- Fibrates
- Rare reported causes: nifedipine
4
Q
What drugs can cause liver cirrhosis?
A
- Methotrexate
- Methyldopa
- Amiodarone
