Cytotoxic Agents Flashcards
What are the main/generic S/E of cytotoxic agents?
- Gout
- Alopecia
- Deafness
- Normoblastic Anaemia
- Pancytopenia
Name an alkylating agent.
Cyclophosphamide
What are the adverse effects of cyclophosphamide?
- Haemorrhagic cystitis
- Myelosuppression
- TCC
Name 2 cytotoxic antibiotics.
Bleomycin
Doxorubicin
What is the mmain side effect of bleomycin?
Lung fibrosis
What is the main side effect of doxorubicin?
Cardiomyopathy
Name 4 antimetabolite cytotoxic agents.
- Methotrexate
- 5-Fluorouracil
- 6-Mercaptopurine
- Cytarabine
What side effect do all antimetabolite cytotoxic agents have in common?
Myelosuppression
What are the adverse effects of methotrexate?
- Myelosuppression
- Mucositis
- Liver fibrosis
- Lung fibrosis
What are the adverse effects of Fluorouracil?
- Myelosuppression
- Mucositis
- Dermatitis
What is the main S/E of 6-mercaptopurine?
Myelosuppression
What are the adverse effects of cytarabine?
- Myelosuppression
- Ataxia
Name 2 cytotoxic agents that act on microtubules.
Vinicristine
Docetaxel
What are the adverse effects of Vinicristine?
- Peripheral neuropathy (reversible)
- Paralytic ileus
What are some S/E of Docetaxel?
Neutropenia