Cytotoxic Agents Flashcards

1
Q

What are the main/generic S/E of cytotoxic agents?

A
  • Gout
  • Alopecia
  • Deafness
  • Normoblastic Anaemia
  • Pancytopenia
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2
Q

Name an alkylating agent.

A

Cyclophosphamide

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3
Q

What are the adverse effects of cyclophosphamide?

A
  • Haemorrhagic cystitis
  • Myelosuppression
  • TCC
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4
Q

Name 2 cytotoxic antibiotics.

A

Bleomycin

Doxorubicin

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5
Q

What is the mmain side effect of bleomycin?

A

Lung fibrosis

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6
Q

What is the main side effect of doxorubicin?

A

Cardiomyopathy

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7
Q

Name 4 antimetabolite cytotoxic agents.

A
  • Methotrexate
  • 5-Fluorouracil
  • 6-Mercaptopurine
  • Cytarabine
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8
Q

What side effect do all antimetabolite cytotoxic agents have in common?

A

Myelosuppression

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9
Q

What are the adverse effects of methotrexate?

A
  • Myelosuppression
  • Mucositis
  • Liver fibrosis
  • Lung fibrosis
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10
Q

What are the adverse effects of Fluorouracil?

A
  • Myelosuppression
  • Mucositis
  • Dermatitis
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11
Q

What is the main S/E of 6-mercaptopurine?

A

Myelosuppression

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12
Q

What are the adverse effects of cytarabine?

A
  • Myelosuppression
  • Ataxia
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13
Q

Name 2 cytotoxic agents that act on microtubules.

A

Vinicristine

Docetaxel

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14
Q

What are the adverse effects of Vinicristine?

A
  • Peripheral neuropathy (reversible)
  • Paralytic ileus
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15
Q

What are some S/E of Docetaxel?

A

Neutropenia

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16
Q

Two other cytotoxic agents are Cisplatin and Hydroxyurea.

What are their main side effects?

A
  • Cisplatin - Ototoxicity, Peripheral neuropathy, hypomagnesaemia.
  • Hydroxyurea - myelosuppression