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Path questions imperialendo.co.uk > Transplantation > Flashcards

Transplantation Flashcards

1
Q

Choose the most appropriate answer from the list

  • Allogenic Transplantation
  • HLA Type I
  • Amyloidosis
  • HLA Type II
  • Autologous Transplantation
  • HLA Type III
  • Azathioprine
  • Invasive Aspergillosis
  • Cytomegalovirus
  • Prednisolone
  • Graft Failure
  • Haemophilus Influenza
  • Herpes Simplex Virus

Infectious agent most commonly responsible for disease in BMT

A

Cytomegalovirus

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2
Q

Choose the most appropriate answer from the list

  • Allogenic Transplantation
  • HLA Type I
  • Amyloidosis
  • HLA Type II
  • Autologous Transplantation
  • HLA Type III
  • Azathioprine
  • Invasive Aspergillosis
  • Cytomegalovirus
  • Prednisolone
  • Graft Failure
  • Haemophilus Influenza
  • Herpes Simplex Virus

Increased risk of Graft vs Host Disease when this is mismatched

A

HLA Type II

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3
Q

Choose the most appropriate answer from the list

  • Allogenic Transplantation
  • HLA Type I
  • Amyloidosis
  • HLA Type II
  • Autologous Transplantation
  • HLA Type III
  • Azathioprine
  • Invasive Aspergillosis
  • Cytomegalovirus
  • Prednisolone
  • Graft Failure
  • Haemophilus Influenza
  • Herpes Simplex Virus

BMT Patient presents with shortness of breath, pleuritic chest pain and fever post-transplantation

A

Invasive Aspergillosis

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4
Q

Choose the most appropriate answer from the list

  • Allogenic Transplantation
  • HLA Type I
  • Amyloidosis
  • HLA Type II
  • Autologous Transplantation
  • HLA Type III
  • Azathioprine
  • Invasive Aspergillosis
  • Cytomegalovirus
  • Prednisolone
  • Graft Failure
  • Haemophilus Influenza
  • Herpes Simplex Virus

Preferred BMT treatment method for lymphoma or solid tumours

A

Autologous Transplantation

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5
Q

Choose the most appropriate answer from the list

  • Allogenic Transplantation
  • HLA Type I
  • Amyloidosis
  • HLA Type II
  • Autologous Transplantation
  • HLA Type III
  • Azathioprine
  • Invasive Aspergillosis
  • Cytomegalovirus
  • Prednisolone
  • Graft Failure
  • Haemophilus Influenza
  • Herpes Simplex Virus

Immunosuppressive agent used post-transplant

A

Prednisolone

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6
Q

Choose the most appropriate answer from the list

  • Autologous
  • HIV
  • Allogeneic
  • Multiple Sclerosis
  • Xenographic
  • Umbilical Cord Blood
  • Myeloablative allogeneic transplants
  • Non- myeloablative allogeneic transplants
  • Graft versus host disease
  • Oral Carcinoma

The type of transplantation where the persons own cells are used to be transplanted

A

Autologous

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7
Q

Choose the most appropriate answer from the list

  • Autologous
  • HIV
  • Allogeneic
  • Multiple Sclerosis
  • Xenographic
  • Umbilical Cord Blood
  • Myeloablative allogeneic transplants
  • Non- myeloablative allogeneic transplants
  • Graft versus host disease
  • Oral Carcinoma

The type of transplantation where another person of the same species are used for the transplant.

A

Allogeneic

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8
Q

Choose the most appropriate answer from the list

  • Autologous
  • HIV
  • Allogeneic
  • Multiple Sclerosis
  • Xenographic
  • Umbilical Cord Blood
  • Myeloablative allogeneic transplants
  • Non- myeloablative allogeneic transplants
  • Graft versus host disease
  • Oral Carcinoma

The type of transplantation done where grafts of animals are used for the transplant

A

Xenographic

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9
Q

Choose the most appropriate answer from the list

  • Autologous
  • HIV
  • Allogeneic
  • Multiple Sclerosis
  • Xenographic
  • Umbilical Cord Blood
  • Myeloablative allogeneic transplants
  • Non- myeloablative allogeneic transplants
  • Graft versus host disease
  • Oral Carcinoma

The process where chemotherapy and irradiation are given to eradicate the patients disease prior to the infusion of haematopoetic stem cells.

A

Myeloablative allogeneic transplants

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10
Q

Choose the most appropriate answer from the list

  • Autologous
  • HIV
  • Allogeneic
  • Multiple Sclerosis
  • Xenographic
  • Umbilical Cord Blood
  • Myeloablative allogeneic transplants
  • Non- myeloablative allogeneic transplants
  • Graft versus host disease
  • Oral Carcinoma

The patient is at higher risk of this after Haematopoetic stem cell transplantation

A

Oral Carcinoma

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11
Q

Choose the most appropriate answer from the list

  • Autologous stem cell transplant
  • Methotrexate + ciclosporin
  • Allogeneic stem cell transplant
  • R-CHOP
  • Blood transfusion
  • Total body irradiation
  • Corticosteroids
  • Watch and wait
  • Cyclophosphamide
  • Imatinib
  • Melphalan
  • Methotrexate

50 year old patient with diffuse large B cell lymphoma relapses after R-CHOP.

A

Autologous stem cell transplant

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12
Q

Choose the most appropriate answer from the list

  • Autologous stem cell transplant
  • Methotrexate + ciclosporin
  • Allogeneic stem cell transplant
  • R-CHOP
  • Blood transfusion
  • Total body irradiation
  • Corticosteroids
  • Watch and wait
  • Cyclophosphamide
  • Imatinib
  • Melphalan
  • Methotrexate

A 60 year old woman undergoing preparation for allogeneic stem cell transplant show signs of diarrhoea and pancreatitis. What is the most likely cause?

A

Total body irradiation

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13
Q

Choose the most appropriate answer from the list

  • Autologous stem cell transplant
  • Methotrexate + ciclosporin
  • Allogeneic stem cell transplant
  • R-CHOP
  • Blood transfusion
  • Total body irradiation
  • Corticosteroids
  • Watch and wait
  • Cyclophosphamide
  • Imatinib
  • Melphalan
  • Methotrexate

A 3 year old girl has just been diagnosed with Fanconi’s anaemia, what is the best long term treatment for her?

A

Allogeneic stem cell transplant

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14
Q

Choose the most appropriate answer from the list

  • Autologous stem cell transplant
  • Methotrexate + ciclosporin
  • Allogeneic stem cell transplant
  • R-CHOP
  • Blood transfusion
  • Total body irradiation
  • Corticosteroids
  • Watch and wait
  • Cyclophosphamide
  • Imatinib
  • Melphalan
  • Methotrexate

Primary therapy for GVHD.

A

Corticosteroids

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15
Q

Choose the most appropriate answer from the list

  • Autologous stem cell transplant
  • Methotrexate + ciclosporin
  • Allogeneic stem cell transplant
  • R-CHOP
  • Blood transfusion
  • Total body irradiation
  • Corticosteroids
  • Watch and wait
  • Cyclophosphamide
  • Imatinib
  • Melphalan
  • Methotrexate

Patient due to undergo allogeneic stem cell transplant requires GVHD prophylaxis.

A

Methotrexate + ciclosporin

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16
Q

Choose the most appropriate answer from the list

  • Acute cellular rejection
  • Hyperacute rejection
  • Acute on Chronic rejection
  • Kidney
  • Antibody mediated rejection
  • Liver
  • Allograft
  • Lung
  • Autograft
  • Xenograft
  • Chronic rejection
  • Graft Vs host disease
  • Heart

A type of organ transplantation between different species

A

Xenograft

17
Q

Choose the most appropriate answer from the list

  • Acute cellular rejection
  • Hyperacute rejection
  • Acute on Chronic rejection
  • Kidney
  • Antibody mediated rejection
  • Liver
  • Allograft
  • Lung
  • Autograft
  • Xenograft
  • Chronic rejection
  • Graft Vs host disease
  • Heart

5 yo patient with AML was treated with bone marrow transplant, a few day later presents with skin rash, nausea, vomiting, abdominal pain and jaundice.

A

Graft Vs host disease

18
Q

Choose the most appropriate answer from the list

  • Acute cellular rejection
  • Hyperacute rejection
  • Acute on Chronic rejection
  • Kidney
  • Antibody mediated rejection
  • Liver
  • Allograft
  • Lung
  • Autograft
  • Xenograft
  • Chronic rejection
  • Graft Vs host disease
  • Heart

One day after kidney transplant, blood test shows increased creatinine, biopsy shows infiltrations of phagocytes, T cells, B cells and NK cells

A

Acute cellular reaction

19
Q

Choose the most appropriate answer from the list

  • Acute cellular rejection
  • Hyperacute rejection
  • Acute on Chronic rejection
  • Kidney
  • Antibody mediated rejection
  • Liver
  • Allograft
  • Lung
  • Autograft
  • Xenograft
  • Chronic rejection
  • Graft Vs host disease
  • Heart

An organ transplant where HLA matching is used to allocate donor

A

Allograft

20
Q

Choose the most appropriate answer from the list

  • Acute cellular rejection
  • Hyperacute rejection
  • Acute on Chronic rejection
  • Kidney
  • Antibody mediated rejection
  • Liver
  • Allograft
  • Lung
  • Autograft
  • Xenograft
  • Chronic rejection
  • Graft Vs host disease
  • Heart

A type of transplant in which HLA matching is not important

A

Allograft

21
Q

Choose the most appropriate answer from the list

  • T-cell mediated rejection
  • Xenotransplantation
  • Antibody mediated rejection
  • Combined T-cell mediated and antibody-mediated rejection
  • Graft-versus-tumour disease
  • Post-transplantation infections
  • Post-transplantation malignancy
  • Immunosuppression
  • Post-transplant lymphoproliferative disorder
  • Graft-versus-host effect

This is a common complication occurring after a stem cell or bone marrow transplantation. The intensity of this condition is related to the degree of HLA-incompatibility.

A

Graft-versus-host effect

22
Q

Choose the most appropriate answer from the list

  • T-cell mediated rejection
  • Xenotransplantation
  • Antibody mediated rejection
  • Combined T-cell mediated and antibody-mediated rejection
  • Graft-versus-tumour disease
  • Post-transplantation infections
  • Post-transplantation malignancy
  • Immunosuppression
  • Post-transplant lymphoproliferative disorder
  • Graft-versus-host effect

The major mechanism involved in this immune reaction is the activation of the classical complement pathway by the antigen-antibody complex, leading to formation of the MAC (membrane attack complex).

A

Antibody mediated rejection

23
Q

Choose the most appropriate answer from the list

  • T-cell mediated rejection
  • Xenotransplantation
  • Antibody mediated rejection
  • Combined T-cell mediated and antibody-mediated rejection
  • Graft-versus-tumour disease
  • Post-transplantation infections
  • Post-transplantation malignancy
  • Immunosuppression
  • Post-transplant lymphoproliferative disorder
  • Graft-versus-host effect

A patient with blood group B receives a kidney transplant from a donor with blood group A. What immune reaction is likely to ensue?

A

Antibody mediated rejection

24
Q

Choose the most appropriate answer from the list

  • T-cell mediated rejection
  • Xenotransplantation
  • Antibody mediated rejection
  • Combined T-cell mediated and antibody-mediated rejection
  • Graft-versus-tumour disease
  • Post-transplantation infections
  • Post-transplantation malignancy
  • Immunosuppression
  • Post-transplant lymphoproliferative disorder
  • Graft-versus-host effect

In this Type IV hypersensitivity response, graft function will be compromised and often it is associated with pain over the graft and fever.

A

T-cell mediated rejection

25
Q

Choose the most appropriate answer from the list

  • T-cell mediated rejection
  • Xenotransplantation
  • Antibody mediated rejection
  • Combined T-cell mediated and antibody-mediated rejection
  • Graft-versus-tumour disease
  • Post-transplantation infections
  • Post-transplantation malignancy
  • Immunosuppression
  • Post-transplant lymphoproliferative disorder
  • Graft-versus-host effect

Kaposi’s sarcoma is an example of this type of condition.

A

Post-transplantation malignancy

Path questions imperialendo.co.uk (44 decks)

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