Transplantation Flashcards
Choose the most appropriate answer from the list
- Allogenic Transplantation
- HLA Type I
- Amyloidosis
- HLA Type II
- Autologous Transplantation
- HLA Type III
- Azathioprine
- Invasive Aspergillosis
- Cytomegalovirus
- Prednisolone
- Graft Failure
- Haemophilus Influenza
- Herpes Simplex Virus
Infectious agent most commonly responsible for disease in BMT
Cytomegalovirus
Choose the most appropriate answer from the list
- Allogenic Transplantation
- HLA Type I
- Amyloidosis
- HLA Type II
- Autologous Transplantation
- HLA Type III
- Azathioprine
- Invasive Aspergillosis
- Cytomegalovirus
- Prednisolone
- Graft Failure
- Haemophilus Influenza
- Herpes Simplex Virus
Increased risk of Graft vs Host Disease when this is mismatched
HLA Type II
Choose the most appropriate answer from the list
- Allogenic Transplantation
- HLA Type I
- Amyloidosis
- HLA Type II
- Autologous Transplantation
- HLA Type III
- Azathioprine
- Invasive Aspergillosis
- Cytomegalovirus
- Prednisolone
- Graft Failure
- Haemophilus Influenza
- Herpes Simplex Virus
BMT Patient presents with shortness of breath, pleuritic chest pain and fever post-transplantation
Invasive Aspergillosis
Choose the most appropriate answer from the list
- Allogenic Transplantation
- HLA Type I
- Amyloidosis
- HLA Type II
- Autologous Transplantation
- HLA Type III
- Azathioprine
- Invasive Aspergillosis
- Cytomegalovirus
- Prednisolone
- Graft Failure
- Haemophilus Influenza
- Herpes Simplex Virus
Preferred BMT treatment method for lymphoma or solid tumours
Autologous Transplantation
Choose the most appropriate answer from the list
- Allogenic Transplantation
- HLA Type I
- Amyloidosis
- HLA Type II
- Autologous Transplantation
- HLA Type III
- Azathioprine
- Invasive Aspergillosis
- Cytomegalovirus
- Prednisolone
- Graft Failure
- Haemophilus Influenza
- Herpes Simplex Virus
Immunosuppressive agent used post-transplant
Prednisolone
Choose the most appropriate answer from the list
- Autologous
- HIV
- Allogeneic
- Multiple Sclerosis
- Xenographic
- Umbilical Cord Blood
- Myeloablative allogeneic transplants
- Non- myeloablative allogeneic transplants
- Graft versus host disease
- Oral Carcinoma
The type of transplantation where the persons own cells are used to be transplanted
Autologous
Choose the most appropriate answer from the list
- Autologous
- HIV
- Allogeneic
- Multiple Sclerosis
- Xenographic
- Umbilical Cord Blood
- Myeloablative allogeneic transplants
- Non- myeloablative allogeneic transplants
- Graft versus host disease
- Oral Carcinoma
The type of transplantation where another person of the same species are used for the transplant.
Allogeneic
Choose the most appropriate answer from the list
- Autologous
- HIV
- Allogeneic
- Multiple Sclerosis
- Xenographic
- Umbilical Cord Blood
- Myeloablative allogeneic transplants
- Non- myeloablative allogeneic transplants
- Graft versus host disease
- Oral Carcinoma
The type of transplantation done where grafts of animals are used for the transplant
Xenographic
Choose the most appropriate answer from the list
- Autologous
- HIV
- Allogeneic
- Multiple Sclerosis
- Xenographic
- Umbilical Cord Blood
- Myeloablative allogeneic transplants
- Non- myeloablative allogeneic transplants
- Graft versus host disease
- Oral Carcinoma
The process where chemotherapy and irradiation are given to eradicate the patients disease prior to the infusion of haematopoetic stem cells.
Myeloablative allogeneic transplants
Choose the most appropriate answer from the list
- Autologous
- HIV
- Allogeneic
- Multiple Sclerosis
- Xenographic
- Umbilical Cord Blood
- Myeloablative allogeneic transplants
- Non- myeloablative allogeneic transplants
- Graft versus host disease
- Oral Carcinoma
The patient is at higher risk of this after Haematopoetic stem cell transplantation
Oral Carcinoma
Choose the most appropriate answer from the list
- Autologous stem cell transplant
- Methotrexate + ciclosporin
- Allogeneic stem cell transplant
- R-CHOP
- Blood transfusion
- Total body irradiation
- Corticosteroids
- Watch and wait
- Cyclophosphamide
- Imatinib
- Melphalan
- Methotrexate
50 year old patient with diffuse large B cell lymphoma relapses after R-CHOP.
Autologous stem cell transplant
Choose the most appropriate answer from the list
- Autologous stem cell transplant
- Methotrexate + ciclosporin
- Allogeneic stem cell transplant
- R-CHOP
- Blood transfusion
- Total body irradiation
- Corticosteroids
- Watch and wait
- Cyclophosphamide
- Imatinib
- Melphalan
- Methotrexate
A 60 year old woman undergoing preparation for allogeneic stem cell transplant show signs of diarrhoea and pancreatitis. What is the most likely cause?
Total body irradiation
Choose the most appropriate answer from the list
- Autologous stem cell transplant
- Methotrexate + ciclosporin
- Allogeneic stem cell transplant
- R-CHOP
- Blood transfusion
- Total body irradiation
- Corticosteroids
- Watch and wait
- Cyclophosphamide
- Imatinib
- Melphalan
- Methotrexate
A 3 year old girl has just been diagnosed with Fanconi’s anaemia, what is the best long term treatment for her?
Allogeneic stem cell transplant
Choose the most appropriate answer from the list
- Autologous stem cell transplant
- Methotrexate + ciclosporin
- Allogeneic stem cell transplant
- R-CHOP
- Blood transfusion
- Total body irradiation
- Corticosteroids
- Watch and wait
- Cyclophosphamide
- Imatinib
- Melphalan
- Methotrexate
Primary therapy for GVHD.
Corticosteroids
Choose the most appropriate answer from the list
- Autologous stem cell transplant
- Methotrexate + ciclosporin
- Allogeneic stem cell transplant
- R-CHOP
- Blood transfusion
- Total body irradiation
- Corticosteroids
- Watch and wait
- Cyclophosphamide
- Imatinib
- Melphalan
- Methotrexate
Patient due to undergo allogeneic stem cell transplant requires GVHD prophylaxis.
Methotrexate + ciclosporin
Choose the most appropriate answer from the list
- Acute cellular rejection
- Hyperacute rejection
- Acute on Chronic rejection
- Kidney
- Antibody mediated rejection
- Liver
- Allograft
- Lung
- Autograft
- Xenograft
- Chronic rejection
- Graft Vs host disease
- Heart
A type of organ transplantation between different species
Xenograft
Choose the most appropriate answer from the list
- Acute cellular rejection
- Hyperacute rejection
- Acute on Chronic rejection
- Kidney
- Antibody mediated rejection
- Liver
- Allograft
- Lung
- Autograft
- Xenograft
- Chronic rejection
- Graft Vs host disease
- Heart
5 yo patient with AML was treated with bone marrow transplant, a few day later presents with skin rash, nausea, vomiting, abdominal pain and jaundice.
Graft Vs host disease
Choose the most appropriate answer from the list
- Acute cellular rejection
- Hyperacute rejection
- Acute on Chronic rejection
- Kidney
- Antibody mediated rejection
- Liver
- Allograft
- Lung
- Autograft
- Xenograft
- Chronic rejection
- Graft Vs host disease
- Heart
One day after kidney transplant, blood test shows increased creatinine, biopsy shows infiltrations of phagocytes, T cells, B cells and NK cells
Acute cellular reaction
Choose the most appropriate answer from the list
- Acute cellular rejection
- Hyperacute rejection
- Acute on Chronic rejection
- Kidney
- Antibody mediated rejection
- Liver
- Allograft
- Lung
- Autograft
- Xenograft
- Chronic rejection
- Graft Vs host disease
- Heart
An organ transplant where HLA matching is used to allocate donor
Allograft
Choose the most appropriate answer from the list
- Acute cellular rejection
- Hyperacute rejection
- Acute on Chronic rejection
- Kidney
- Antibody mediated rejection
- Liver
- Allograft
- Lung
- Autograft
- Xenograft
- Chronic rejection
- Graft Vs host disease
- Heart
A type of transplant in which HLA matching is not important
Allograft
Choose the most appropriate answer from the list
- T-cell mediated rejection
- Xenotransplantation
- Antibody mediated rejection
- Combined T-cell mediated and antibody-mediated rejection
- Graft-versus-tumour disease
- Post-transplantation infections
- Post-transplantation malignancy
- Immunosuppression
- Post-transplant lymphoproliferative disorder
- Graft-versus-host effect
This is a common complication occurring after a stem cell or bone marrow transplantation. The intensity of this condition is related to the degree of HLA-incompatibility.
Graft-versus-host effect
Choose the most appropriate answer from the list
- T-cell mediated rejection
- Xenotransplantation
- Antibody mediated rejection
- Combined T-cell mediated and antibody-mediated rejection
- Graft-versus-tumour disease
- Post-transplantation infections
- Post-transplantation malignancy
- Immunosuppression
- Post-transplant lymphoproliferative disorder
- Graft-versus-host effect
The major mechanism involved in this immune reaction is the activation of the classical complement pathway by the antigen-antibody complex, leading to formation of the MAC (membrane attack complex).
Antibody mediated rejection
Choose the most appropriate answer from the list
- T-cell mediated rejection
- Xenotransplantation
- Antibody mediated rejection
- Combined T-cell mediated and antibody-mediated rejection
- Graft-versus-tumour disease
- Post-transplantation infections
- Post-transplantation malignancy
- Immunosuppression
- Post-transplant lymphoproliferative disorder
- Graft-versus-host effect
A patient with blood group B receives a kidney transplant from a donor with blood group A. What immune reaction is likely to ensue?
Antibody mediated rejection
Choose the most appropriate answer from the list
- T-cell mediated rejection
- Xenotransplantation
- Antibody mediated rejection
- Combined T-cell mediated and antibody-mediated rejection
- Graft-versus-tumour disease
- Post-transplantation infections
- Post-transplantation malignancy
- Immunosuppression
- Post-transplant lymphoproliferative disorder
- Graft-versus-host effect
In this Type IV hypersensitivity response, graft function will be compromised and often it is associated with pain over the graft and fever.
T-cell mediated rejection
Choose the most appropriate answer from the list
- T-cell mediated rejection
- Xenotransplantation
- Antibody mediated rejection
- Combined T-cell mediated and antibody-mediated rejection
- Graft-versus-tumour disease
- Post-transplantation infections
- Post-transplantation malignancy
- Immunosuppression
- Post-transplant lymphoproliferative disorder
- Graft-versus-host effect
Kaposi’s sarcoma is an example of this type of condition.
Post-transplantation malignancy
