Coagulation Flashcards
Choose the most appropriate answer from the list.
- Abciximab
- Stop Warfarin for 1-2 days
- Alteplase
- Stop Warfarin, give FFP
- Aspirin
- Tranexamic acid
- Clopidogrel
- Unfractionated Heparin
- Dabigatran
- Warfarin
- Fondaparinux
- LMW Heparin
- Stop Warfarin, give 1-5mg Vit K
A 64yo lady is accidentally given an overdose of this drug. It is reversed with protamine sulphate.
Unfractionated Heparin
Choose the most appropriate answer from the list.
- Abciximab
- Stop Warfarin for 1-2 days
- Alteplase
- Stop Warfarin, give FFP
- Aspirin
- Tranexamic acid
- Clopidogrel
- Unfractionated Heparin
- Dabigatran
- Warfarin
- Fondaparinux
- LMW Heparin
- Stop Warfarin, give 1-5mg Vit K
A 54yo man at risk of thromboembolic and atherothrombotic events is prescribed this ADP-receptor antagonist along with Aspirin
Clopidogrel
Choose the most appropriate answer from the list.
- Abciximab
- Stop Warfarin for 1-2 days
- Alteplase
- Stop Warfarin, give FFP
- Aspirin
- Tranexamic acid
- Clopidogrel
- Unfractionated Heparin
- Dabigatran
- Warfarin
- Fondaparinux
- LMW Heparin
- Stop Warfarin, give 1-5mg Vit K
A 74yo man on Warfarin has an INR of 9
Stop Warfarin, give 1-5mg Vit K
Choose the most appropriate answer from the list.
- Abciximab
- Stop Warfarin for 1-2 days
- Alteplase
- Stop Warfarin, give FFP
- Aspirin
- Tranexamic acid
- Clopidogrel
- Unfractionated Heparin
- Dabigatran
- Warfarin
- Fondaparinux
- LMW Heparin
- Stop Warfarin, give 1-5mg Vit K
A 34yo women with menorrhagia is managed with this anti-fibrinolytic agent
Tranexamic acid
Choose the most appropriate answer from the list.
- Abciximab
- Stop Warfarin for 1-2 days
- Alteplase
- Stop Warfarin, give FFP
- Aspirin
- Tranexamic acid
- Clopidogrel
- Unfractionated Heparin
- Dabigatran
- Warfarin
- Fondaparinux
- LMW Heparin
- Stop Warfarin, give 1-5mg Vit K
This GPIIb/IIIa inhibitor can be used in the prevention of ischaemic complications in high risk patients undergoing percutaneous transluminal coronary intervention
Abciximab
Choose the most appropriate answer from the list.
- Activated Partial Thromboplastin Time
- Fasting Plasma Homocysteine Levels
- Activated Protein C Resistance tests
- Heparin Antibodies
- Fibrinogen Levels
- Urine Human Chorionic Gonadotrophin
- Anticardiolipin antibodies
- Flow Cytometry
- Plain film X-ray
- Ultrasound
- Full Blood Count
- D-dimer
- Prothrombin Time
A 32 year old woman has a GP check up. She gave birth to a premature child 10 weeks ago after suffering 3 miscarriages. On close examination she appears to have a purple mottled lace-like rash. What is the most appropriate diagnostic test?
Anticardiolipin antibodies
Choose the most appropriate answer from the list.
- Activated Partial Thromboplastin Time
- Fasting Plasma Homocysteine Levels
- Activated Protein C Resistance tests
- Heparin Antibodies
- Fibrinogen Levels
- Urine Human Chorionic Gonadotrophin
- Anticardiolipin antibodies
- Flow Cytometry
- Plain film X-ray
- Ultrasound
- Full Blood Count
- D-dimer
- Prothrombin Time
A 28 year old woman presents to the emergency department with sudden onset chest pain and shortness of breath. History reveals recent recurrent vomiting, tiredness, frequently low moods and over 30 days since her last menstrual period. What is the most appropriate diagnostic test?
Urine Human Chorionic Gonadotrophin
Choose the most appropriate answer from the list.
- Activated Partial Thromboplastin Time
- Fasting Plasma Homocysteine Levels
- Activated Protein C Resistance tests
- Heparin Antibodies
- Fibrinogen Levels
- Urine Human Chorionic Gonadotrophin
- Anticardiolipin antibodies
- Flow Cytometry
- Plain film X-ray
- Ultrasound
- Full Blood Count
- D-dimer
- Prothrombin Time
A 60 year old man presents with headaches, blurred vision and ringing in his ears. He has flushed cheeks and complains he has been itching after hot baths. What is the most appropriate diagnostic test?
Full Blood Count
Choose the most appropriate answer from the list.
- Activated Partial Thromboplastin Time
- Fasting Plasma Homocysteine Levels
- Activated Protein C Resistance tests
- Heparin Antibodies
- Fibrinogen Levels
- Urine Human Chorionic Gonadotrophin
- Anticardiolipin antibodies
- Flow Cytometry
- Plain film X-ray
- Ultrasound
- Full Blood Count
- D-dimer
- Prothrombin Time
A tall and thin 22 year old man presents with right sided numbness and weakness on his body and difficulty formulating speech. His symptoms resolve whilst in hospital. On examination, he appears to have a downward dislocation of his lens and long limbs relative to his body. What is the most appropriate diagnostic test?
Fasting Plasma Homocysteine Levels
Choose the most appropriate answer from the list.
- Activated Partial Thromboplastin Time
- Fasting Plasma Homocysteine Levels
- Activated Protein C Resistance tests
- Heparin Antibodies
- Fibrinogen Levels
- Urine Human Chorionic Gonadotrophin
- Anticardiolipin antibodies
- Flow Cytometry
- Plain film X-ray
- Ultrasound
- Full Blood Count
- D-dimer
- Prothrombin Time
A 55 year old Caucasian woman arrives in A&E with a red, painful, swollen leg. History reveals she recently travelled to London from Aberdeen via train. She says she has had a previous episode 7 years ago and her 2 of her siblings have also previously experienced similar symptoms. What is the most appropriate diagnostic test?
Activated Protein C Resistance tests (Factor V Leiden)
Choose the most appropriate answer from the list.
- Warfarin
- Von Willebrand Disease
- Heparin (unfractionated)
- INR
- LMWH
- Vitamin K
- APTT
- Protein S
- PT
- Protein C
- Bleeding time
- Antithrombin
- Factor VIII
- Factor IX
Haemophilia A deficient in…
Factor VIII
Choose the most appropriate answer from the list.
- Warfarin
- Von Willebrand Disease
- Heparin (unfractionated)
- INR
- LMWH
- Vitamin K
- APTT
- Protein S
- PT
- Protein C
- Bleeding time
- Antithrombin
- Factor VIII
- Factor IX
Can be teratogenic
Warfarin
Choose the most appropriate answer from the list.
- Warfarin
- Von Willebrand Disease
- Heparin (unfractionated)
- INR
- LMWH
- Vitamin K
- APTT
- Protein S
- PT
- Protein C
- Bleeding time
- Antithrombin
- Factor VIII
- Factor IX
Christmas Disease
Factor IX
Choose the most appropriate answer from the list.
- Warfarin
- Von Willebrand Disease
- Heparin (unfractionated)
- INR
- LMWH
- Vitamin K
- APTT
- Protein S
- PT
- Protein C
- Bleeding time
- Antithrombin
- Factor VIII
- Factor IX
Increases APTT and bleeding time
Von Willebrand Disease
Choose the most appropriate answer from the list.
- Warfarin
- Von Willebrand Disease
- Heparin (unfractionated)
- INR
- LMWH
- Vitamin K
- APTT
- Protein S
- PT
- Protein C
- Bleeding time
- Antithrombin
- Factor VIII
- Factor IX
Potentiated by heparin
Antithrombin
Choose the most appropriate answer from the list.
- Capillary abnormality
- Protein C deficiency
- Chronic Lymphocytic Leukaemia
- Prothrombin deficiency
- Chronic Myeloid Leukaemia
- Warfarin overdose
- Disseminated Intravascular Coagulation
- Vitamin K deficiency
- Factor IX deficiency
- Von Willebrand disease
- Factor VIII deficiency
- Platelet count 19,000 per microL
- Platelet count 26,000 per microL
A 12 year old boy had a tooth removed at the dentist, it initially stopped bleeding but once back at home it began to continuously ooze blood.
Factor VIII deficiency
Choose the most appropriate answer from the list.
- Capillary abnormality
- Protein C deficiency
- Chronic Lymphocytic Leukaemia
- Prothrombin deficiency
- Chronic Myeloid Leukaemia
- Warfarin overdose
- Disseminated Intravascular Coagulation
- Vitamin K deficiency
- Factor IX deficiency
- Von Willebrand disease
- Factor VIII deficiency
- Platelet count 19,000 per microL
- Platelet count 26,000 per microL
A fit and well 88 year old lady has purple blotches on the palms of both hands. They are not painful.
Capillary abnormality
Choose the most appropriate answer from the list.
- Capillary abnormality
- Protein C deficiency
- Chronic Lymphocytic Leukaemia
- Prothrombin deficiency
- Chronic Myeloid Leukaemia
- Warfarin overdose
- Disseminated Intravascular Coagulation
- Vitamin K deficiency
- Factor IX deficiency
- Von Willebrand disease
- Factor VIII deficiency
- Platelet count 19,000 per microL
- Platelet count 26,000 per microL
A 23 year old woman presents to her GP with several bruises over her body. She has no idea where they came from. The GP finds she has been experiencing heavy periods
Von Willebrand disease
Choose the most appropriate answer from the list.
- Capillary abnormality
- Protein C deficiency
- Chronic Lymphocytic Leukaemia
- Prothrombin deficiency
- Chronic Myeloid Leukaemia
- Warfarin overdose
- Disseminated Intravascular Coagulation
- Vitamin K deficiency
- Factor IX deficiency
- Von Willebrand disease
- Factor VIII deficiency
- Platelet count 19,000 per microL
- Platelet count 26,000 per microL
A 12 year old boy is admitted to hospital with recent onset wide spread petechiae. Lab investigations reveal an abnormality that reveals the cause of the bleeding.
Platelet count 19,000 per microL
Choose the most appropriate answer from the list.
- Capillary abnormality
- Protein C deficiency
- Chronic Lymphocytic Leukaemia
- Prothrombin deficiency
- Chronic Myeloid Leukaemia
- Warfarin overdose
- Disseminated Intravascular Coagulation
- Vitamin K deficiency
- Factor IX deficiency
- Von Willebrand disease
- Factor VIII deficiency
- Platelet count 19,000 per microL
- Platelet count 26,000 per microL
After a very recent heart valve replacement, a 62 year old man is admitted with haematuria and a nose bleed. He is on warfarin and his INR is measured as 4.1
Prothrombin deficiency
A 1 year old boy who presents with multiple bruises, mucosal bleeding and a swollen painful knee, that occurred spontaneously with no history of trauma. His Hb was 122g/, WCC 7x109/litre and MCV 75fl. aPTT is prolonged, bleeding time and PT are normal. Rank the following treatments given this information, putting the MOST APPROPRIATE treatment first, and the least appropriate treatment last.
A) Clotting Factor VIII concentrate
B) Clotting Factor IX concentrate
C) Desmopressin
D) Fresh frozen plasma and cryoprecipitate
E) IV immunoglobulin
Clotting Factor VIII concentrate
Fresh frozen plasma and cryoprecipitate
Desmopressin
Clotting Factor IX concentrate
IV immunoglobulin
Choose the most appropriate answer from the list
- Acute Lymphoblastic Leukaemia
- Henoch-Schonlein Purpura
- Beta-Thalassaemia
- Hereditary Spherocytosis
- Diamond-Blackfan Syndrome
- Hodgkin’s Lymphoma
- Dyskeratosis Congenita
- Rhesus Haemolytic Disease
- Fanconi Anaemia
- Shwachman-Diamond Syndrome
- G6PD Deficiency
- Sickle Cell Anaemia
- Haemophilia A
- Thrombocytopenia-Absent Radius Syndrome
- Haemophilia B
- Von Willebrand Disease
A neonate develops jaundice within a few hours of birth. A blood smear reveals Howell-Jolly bodies. Osmotic fragility test is positive.
Hereditary Spherocytosis
Choose the most appropriate answer from the list
- Acute Lymphoblastic Leukaemia
- Henoch-Schonlein Purpura
- Beta-Thalassaemia
- Hereditary Spherocytosis
- Diamond-Blackfan Syndrome
- Hodgkin’s Lymphoma
- Dyskeratosis Congenita
- Rhesus Haemolytic Disease
- Fanconi Anaemia
- Shwachman-Diamond Syndrome
- G6PD Deficiency
- Sickle Cell Anaemia
- Haemophilia A
- Thrombocytopenia-Absent Radius Syndrome
- Haemophilia B
- Von Willebrand Disease
A neonate is found to have a cleft palate and abnormal thumbs. Investigations reveal a macrocytic anaemia.
Diamond-Blackfan Syndrome
Choose the most appropriate answer from the list
- Acute Lymphoblastic Leukaemia
- Henoch-Schonlein Purpura
- Beta-Thalassaemia
- Hereditary Spherocytosis
- Diamond-Blackfan Syndrome
- Hodgkin’s Lymphoma
- Dyskeratosis Congenita
- Rhesus Haemolytic Disease
- Fanconi Anaemia
- Shwachman-Diamond Syndrome
- G6PD Deficiency
- Sickle Cell Anaemia
- Haemophilia A
- Thrombocytopenia-Absent Radius Syndrome
- Haemophilia B
- Von Willebrand Disease
A four year old boy comes in with generalised fatigue, bruising and a history of frequent infections. On examination the boy has palpable neck swellings.
Acute Lymphoblastic Leukaemia
Choose the most appropriate answer from the list
- Acute Lymphoblastic Leukaemia
- Henoch-Schonlein Purpura
- Beta-Thalassaemia
- Hereditary Spherocytosis
- Diamond-Blackfan Syndrome
- Hodgkin’s Lymphoma
- Dyskeratosis Congenita
- Rhesus Haemolytic Disease
- Fanconi Anaemia
- Shwachman-Diamond Syndrome
- G6PD Deficiency
- Sickle Cell Anaemia
- Haemophilia A
- Thrombocytopenia-Absent Radius Syndrome
- Haemophilia B
- Von Willebrand Disease
A 3 month old infant with absent radii bilaterally but normal thumbs, presents with bruising, petechiae and nosebleeds.
Thrombocytopenia-Absent Radius Syndrome
Choose the most appropriate answer from the list
- Acute Lymphoblastic Leukaemia
- Henoch-Schonlein Purpura
- Beta-Thalassaemia
- Hereditary Spherocytosis
- Diamond-Blackfan Syndrome
- Hodgkin’s Lymphoma
- Dyskeratosis Congenita
- Rhesus Haemolytic Disease
- Fanconi Anaemia
- Shwachman-Diamond Syndrome
- G6PD Deficiency
- Sickle Cell Anaemia
- Haemophilia A
- Thrombocytopenia-Absent Radius Syndrome
- Haemophilia B
- Von Willebrand Disease
A 2 year old boy presents with bleeding gums. On further investigation Hb, WBC and platelets are normal. APTT is prolonged, bleeding time is prolonged and PT is normal.
Von Willebrand Disease
Choose the most appropriate answer from the list
- Antiphospholipid syndrome
- Hypertrophic Obstructive Cardiomyopathy
- Arrythmia
- Paroxysmal nocturnal haematuria
- Chronic Kidney Failure
- Protein C deficiency
- Diabetes Mellitus
- Renal cancer
- Factor V Leiden
- Scott Syndrome
- Haemophilia A
- Uraemia
- Haemophilia B
- Wiskott-Aldrich Syndrome
- Heparin-Induced thrombocytopenia
- Von Willebrand Disease
A 23 year old student’s mother calls the ambulance as her daughter has suddenly developed difficulty breathing. She has 9/10 central chest pain that began at rest. There have been no previous episodes. She is on OTC vitamins and the oral contraceptive pill. Her mother says she had 2 similar episodes in her youth before she stopped taking the pill. Investigations reveal both mother and daughter have activated protein C resistance.
Factor V Leiden
Choose the most appropriate answer from the list
- Antiphospholipid syndrome
- Hypertrophic Obstructive Cardiomyopathy
- Arrythmia
- Paroxysmal nocturnal haematuria
- Chronic Kidney Failure
- Protein C deficiency
- Diabetes Mellitus
- Renal cancer
- Factor V Leiden
- Scott Syndrome
- Haemophilia A
- Uraemia
- Haemophilia B
- Wiskott-Aldrich Syndrome
- Heparin-Induced thrombocytopenia
- Von Willebrand Disease
A 60 year old man with severe abdominal pain is brought into the emergency department. His GP says he has recently reported changes in his waterworks. His urine is darker, especially in the evening. He has been feeling tired recently and had seemed anxious that he had not been able to satisfy his wife in bed.
Paroxysmal nocturnal haematuria
Choose the most appropriate answer from the list
- Antiphospholipid syndrome
- Hypertrophic Obstructive Cardiomyopathy
- Arrythmia
- Paroxysmal nocturnal haematuria
- Chronic Kidney Failure
- Protein C deficiency
- Diabetes Mellitus
- Renal cancer
- Factor V Leiden
- Scott Syndrome
- Haemophilia A
- Uraemia
- Haemophilia B
- Wiskott-Aldrich Syndrome
- Heparin-Induced thrombocytopenia
- Von Willebrand Disease
A 35 year old woman complains of a swollen leg. On examination, her left leg is red, warm and larger in diameter than the right. She has had similar episodes in the past and has also had 2 spontaneous miscarriages. An ELISA confirms the presence of anticardiolipin antibodies.
Antiphospholipid syndrome
Choose the most appropriate answer from the list
- Antiphospholipid syndrome
- Hypertrophic Obstructive Cardiomyopathy
- Arrythmia
- Paroxysmal nocturnal haematuria
- Chronic Kidney Failure
- Protein C deficiency
- Diabetes Mellitus
- Renal cancer
- Factor V Leiden
- Scott Syndrome
- Haemophilia A
- Uraemia
- Haemophilia B
- Wiskott-Aldrich Syndrome
- Heparin-Induced thrombocytopenia
- Von Willebrand Disease
A man with a history of sudden death in his family collapses in a supermarket. He is unconscious on arrival at the local hospital but is treated with thrombolytic agents. When he regains consciousness a few hours later, the registrar suggests the patient that a pacemaker be placed.
Hypertrophic Obstructive Cardiomyopathy
