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Path questions imperialendo.co.uk > Myeloproliferative disorders > Flashcards

Myeloproliferative disorders Flashcards

1
Q

Choose the most appropriate answer from the list

  • Chronic granulocytic leukaemia
  • Polycythaemia vera
  • Chronic idiopathic myelofibrosis
  • Pseudopolycythaemia
  • Myelodysplasia
  • Essential thrombocythaemia
  • Idiopathic erythrocytosis
  • Acute myeloblastic leukaemia

Raised haematocrit with no increase in blood volume. JAK2 mutation negative.

A

Pseudopolycythaemia

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2
Q

Choose the most appropriate answer from the list

  • Chronic granulocytic leukaemia
  • Polycythaemia vera
  • Chronic idiopathic myelofibrosis
  • Pseudopolycythaemia
  • Myelodysplasia
  • Essential thrombocythaemia
  • Idiopathic erythrocytosis
  • Acute myeloblastic leukaemia

Can be associated with mutations of exon 12 in JAK2.

A

Idiopathic erythrocytosis

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3
Q

Choose the most appropriate answer from the list

  • Chronic granulocytic leukaemia
  • Polycythaemia vera
  • Chronic idiopathic myelofibrosis
  • Pseudopolycythaemia
  • Myelodysplasia
  • Essential thrombocythaemia
  • Idiopathic erythrocytosis
  • Acute myeloblastic leukaemia

Most patients will have the JAK2 V617F mutation.

A

Polycythaemia vera

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4
Q

Choose the most appropriate answer from the list

  • Chronic granulocytic leukaemia
  • Polycythaemia vera
  • Chronic idiopathic myelofibrosis
  • Pseudopolycythaemia
  • Myelodysplasia
  • Essential thrombocythaemia
  • Idiopathic erythrocytosis
  • Acute myeloblastic leukaemia

Chronic condition mainly involving megakaryocytic lineage.

A

Essential thrombocythaemia

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5
Q

Choose the most appropriate answer from the list

  • Chronic granulocytic leukaemia
  • Polycythaemia vera
  • Chronic idiopathic myelofibrosis
  • Pseudopolycythaemia
  • Myelodysplasia
  • Essential thrombocythaemia
  • Idiopathic erythrocytosis
  • Acute myeloblastic leukaemia

Condition that occurs secondary to other haematological disease. Associated with extramedullary haematopoiesis.

A

Chronic idiopathic myelofibrosis

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6
Q

Choose the most appropriate answer from the list

  • Hepatomegaly
  • t(11;14) translocation
  • High Hb, WCC and platelets
  • t(8;14) translocation
  • High platelet count
  • t(8;21) translocation
  • High WCC
  • (9;21) translocation
  • Low Hb, WCC and platelets
  • t(9;22) translocation
  • Low platelet count
  • Teardrop erythrocytes
  • Spherocytes
  • Splenomegaly

A 65 year old man complains of headaches, dizziness and itching after getting out of the shower. On examination he is plethoric. What finding would confirm the diagnosis?

A

High Hb, WCC and platelets

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7
Q

Choose the most appropriate answer from the list

  • Hepatomegaly
  • t(11;14) translocation
  • High Hb, WCC and platelets
  • t(8;14) translocation
  • High platelet count
  • t(8;21) translocation
  • High WCC
  • (9;21) translocation
  • Low Hb, WCC and platelets
  • t(9;22) translocation
  • Low platelet count
  • Teardrop erythrocytes
  • Spherocytes
  • Splenomegaly

A 79 year old lady with splenomegaly is on imatinib. What abnormality is FISH (fluorescence in situ hybridisation) likely to reveal?

A

t(9;22) translocation

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8
Q

Choose the most appropriate answer from the list

  • Hepatomegaly
  • t(11;14) translocation
  • High Hb, WCC and platelets
  • t(8;14) translocation
  • High platelet count
  • t(8;21) translocation
  • High WCC
  • (9;21) translocation
  • Low Hb, WCC and platelets
  • t(9;22) translocation
  • Low platelet count
  • Teardrop erythrocytes
  • Spherocytes
  • Splenomegaly

A 42 year old man presents fever, weight loss, night sweats and abdominal discomfort. Hepatosplenomegaly is noted on examination. The blood film shows leukoerythroblastic cells. What other blood abnormality may be present?

A

Teardrop erythrocytes

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9
Q

Choose the most appropriate answer from the list

  • Hepatomegaly
  • t(11;14) translocation
  • High Hb, WCC and platelets
  • t(8;14) translocation
  • High platelet count
  • t(8;21) translocation
  • High WCC
  • (9;21) translocation
  • Low Hb, WCC and platelets
  • t(9;22) translocation
  • Low platelet count
  • Teardrop erythrocytes
  • Spherocytes
  • Splenomegaly

Headaches, transient ischaemic attacks and deep vein thrombosis are best explained by which abnormality?

A

High platelet count

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10
Q

Choose the most appropriate answer from the list

  • Hepatomegaly
  • t(11;14) translocation
  • High Hb, WCC and platelets
  • t(8;14) translocation
  • High platelet count
  • t(8;21) translocation
  • High WCC
  • (9;21) translocation
  • Low Hb, WCC and platelets
  • t(9;22) translocation
  • Low platelet count
  • Teardrop erythrocytes
  • Spherocytes
  • Splenomegaly

A 50 year old lady presents with headaches and hepatosplenomegaly. The blood film shows megakaryocyte proliferation. What is the full blood count likely to reveal?

A

High platelet count

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Path questions imperialendo.co.uk (44 decks)

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