transfusion reaction II Flashcards

1
Q

blood component commonly associated with transfusion related sepsis?

a. leukopoor
b. washed rbc
c. platelet concentrate
d. platelet pheresis

A

platelet concentrate

Platelets have been the most frequent source of septic transfusion reactions because room temperature storage promotes bacterial growth.

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2
Q

greatest number of deaths due to blood product contamination

a. Y. enterocolitica
b. Pseudomonas putida
c. S. aureus
d. S. epidermidis

A

Staphylococcus aureus

accounts for the greatest number of deaths due to blood product contamination reported to the FDA from FY2011 to 2015, all of which were platelet products (Harmening, 7th edition)
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3
Q

are the most common bacterial contaminants of blood

a. Y. enterocolitica
b. Pseudomonas putida
c. S. aureus
d. S. epidermidis

A

Staphylococcus epidermidis or Staphylococcus aureus are the most
common bacterial contaminants of blood

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4
Q

Most frequently recovered from donated blood and contamination of platelet

a. B. cerues
b. Pseudomonas putida
c. S. aureus
d. S. epidermidis

A

Bacillus cerues,
Staphylococcus epidermidis

Most frequently recovered from donated blood and contamination of platelet

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5
Q

Common isolate of human skin, WAS the most common bacterial contaminants in RBC

a. B. cerues
b. Pseudomonas putida
c. Propionebacterium acnes
d. S. epidermidis

A

Propionebacterium acnes

  • common isolate of HUMAN SKIN
  • WAS the most common bacterial contaminants in rbcs
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6
Q

Most common cause of death by bacterial contaminated blood components

a. Y. enterocolitica
b. Pseudomonas putida
c. S. aureus
d. S. epidermidis

A

Yersinia enterocolitica

According to CDC, it is the Most common cause of death by bacterial contaminated blood components

Most common isolate found in RBC units

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7
Q

what delayed immune transfusion reaction due to an immunologic attack by viable donor lymphocytes
(T cells) contained in the transfused blood component against the transfusion recipient.

a. dhtr
b. ta-gvhd
c. ptp
d. iron overload

A

TA-GVHD Transfusion associated-graft versus host disease

Cause: delayed immune transfusion reaction due to an immunologic attack by viable donor lymphocytes
(T cells) contained in the transfused blood component against the transfusion recipient.

-Recipient who are immunocompromised or with immunodeficiencies, with cancer, or infants are at risk

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8
Q

what DTR has decrease in haptoglobin

a. dhtr
b. ta-gvhd
c. ptp
d. iron overload

A

DHTR

Cause: Incompatible blood transfusion especially KIDD BGS (most common)

Signs and symptoms: Fever, decreased haptoglobin level, mild jaundice, flu-like symptoms, pallor

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9
Q

what DTR has a maculopapular skin rash, scleroderma like, sicca syndrome and diarrhea in stool

a. dhtr
b. ta-gvhd
c. ptp
d. iron overload

A

TA-GVHD Transfusion associated-graft versus host disease

Signs and Symptoms: Fever, maculopapular skin rash, scleroderma-like, sicca syndrome, interstitial pneumonitis, pancytopenia, abnormal liver function (elevated liver function test such as enzymes), diarrhea with bloody stool

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10
Q

what condition will develop in HLA antigen difference between donor and recipient

a. dhtr
b. ta-gvhd
c. ptp
d. iron overload

A

Three conditions must exist for TA-GVHD to develop in a recipient:

  1. HLA antigen difference between donor and recipient
  2. presence of donor immunocompetent cells in the blood component
  3. recipient incapable of rejecting the donor immunocompetent cells
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11
Q

what blood component should be transfused in TA-GVHD

a. leukopoor
b. washed rbc
c. platelet con
d. irradiated blood products

A

TA-GVHS

prevention and treatment

  1. usage of irradiated blood products
  2. usage of immunosuppressive medications
  3. Hematopoietic stem cell transplantation
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12
Q

what DTR is caused by anti - HPA! antibodies

a. dhtr
b. ta-gvhd
c. ptp
d. iron overload

A

Post transfusion purpura

Cause: Anti-platelet antibodies / anti-HPA1(human platelet antigen1) antibodies

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13
Q

delayed, nonimmune complication of transfusion, presenting with multiorgan (i.e., liver, heart, endocrine organs) damage

a. dhtr
b. ta-gvhd
c. ptp
d. iron overload

A

iron overload / transfusion induced/ hemosiderosis/ hemochromatosis

causes : delayed, nonimmune complication of transfusion, presenting with multiorgan (i.e., liver, heart, endocrine organs) damage

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