minor bgs II Flashcards

1
Q

carried on the hematopoietic isoform of the CD44 marker, which is known for its immune adhesion properties

a. dombrock
b. indian
c. Ok
d. Raph

A

ISBT 023 INDIAN
Antigens: Ina , Inb
✓ IN antigens are carried on the hematopoietic isoform of the CD44 marker, which is known for its immune adhesion properties

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2
Q

which of the following BGS is mainly function is a receptors and adhesion molecules

a. dombrock
b. indian
c. Ok
d. Raph

A

ISBT 024 Ok

✓ The OK antigens are carried on CD147, or basigin, a member of the immunoglobulin superfamily that mainly functions as receptors and adhesion molecules

✓ Basigin is a receptor essential for invasion by Plasmodium falciparum

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3
Q

which of the following BGS is a receptor essential for invasion by Plasmodium falciparum

a. dombrock
b. indian
c. Ok
d. Raph

A

ISBT 024 Ok

✓ The OK antigens are carried on CD147, or basigin, a member of the immunoglobulin superfamily that mainly functions as receptors and adhesion molecules

✓ Basigin is a receptor essential for invasion by Plasmodium falciparum

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4
Q

is located on CD151, a tetraspanin, which appears to be essential for the assembly of basement membranes in the kidney and skin

a. dombrock
b. indian
c. Ok
d. Raph

A

ISBT 025 RAPH
✓ The only antigen in the Raph system is MER2
✓ It was shown that MER2 is located on CD151, a tetraspanin, which appears to be essential for the assembly of basement membranes in the kidney and skin

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5
Q

where does GILL located

a. AE1
b. chromosome 1
c. AQP3
d. ERMAP

A

ISBT 029 GILL

✓ The ISBT Gill system symbol is GIL and number 029. There is only one antigen, GIL.

✓ This antigen is found on the glycerol transporter AQUAPORIN 3 (AQP3), a member of the major intrinsic protein family of water and glycerol channels

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6
Q

Absence of RhAG due to inactivating mutations in RHAG results in the __________

A.. Rhmod phenotype
B. Rhnull phenotype

A

Absence of RhAG due to inactivating mutations in RHAG results in the Rhnull phenotype;

some missense mutations in RHAG result in the Rhmod phenotype.

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7
Q

which of the following are antigens in RHAG

a. duclos
b. ola
c. DSLG
d. aota

A

Four antigens have been assigned to the RHAG system:

Duclos (high prevalence),

Ola (very rare, low prevalence),

the high prevalence DSLK (for Duclos-like), and

RHAG4

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8
Q

The GBGTI gene produces ___________, which causes the formation of the Forssman glycolipid by the addition of N-acetylgalactosamine (GalNAc) to the P antigen.

a. glycosyltransferase
b. aquaporin 3
c. hematopoietic isoform
d. aota

A

isbt 031 FORS

The GBGTI gene produces glycosyltransferase, which causes the formation of the Forssman glycolipid by the addition of N-acetylgalactosamine (GalNAc) to the P antigen.

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9
Q

human cells that express the ______may have an increased susceptibility to E. coli infection.

a. JMH
b. GIL
c. FORS1
d. INa

A

ISBT 031 FORS

The Forssman glycolipid can serve as a receptor for pathogens such as Escherichia coli, making one believe that human cells that express the FORS1 may have an increased susceptibility to E. coli infection.

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10
Q

which o fthe following BGS The gene ABCG2 is located on chromosome 4 at position 4q22.1. Is a member of the adenosine triphosphate (ATP) binding cassette transporters broadly distributed throughout the body. It is involved in multidrug resistance in tumor cells, presenting a problem in chemotherapy

a. scianna
b. indian
c. GILL
d. JR

A

ISBT 032 JR
✓ Jra is a high-prevalence antigen in most populations; the Jr(a–) phenotype is found more commonly in Japanese

✓ The gene ABCG2 is located on chromosome 4 at position 4q22.1. The encoded protein, ABCG2, is a member of the adenosine triphosphate (ATP) binding cassette transporters broadly distributed throughout the body. It is involved in multidrug resistance in tumor cells, presenting a problem in chemotherapy

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11
Q

what gene is involved in multidrug resistance in tumor cells, presenting a problem in chemotherapy

a. ABCG1
b. ABCG2
c. DUCHLOS
d ABCG6

A

ISBT 032 JR
✓ Jra is a high-prevalence antigen in most populations; the Jr(a–) phenotype is found more commonly in Japanese

✓ The gene ABCG2 is located on chromosome 4 at position 4q22.1. The encoded protein, ABCG2, is a member of the adenosine triphosphate (ATP) binding cassette transporters broadly distributed throughout the body. It is involved in multidrug resistance in tumor cells, presenting a problem in chemotherapy

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12
Q

what is the gene involved in functions in heme synthesis with the ATP-dependent uptake of heme and porphyrins into mitochondria.

a. ABCG1
b. ABCG2
c. DUCHLOS
d ABCG6

A

The Lan gene, ABCB6, located on chromosome 2 at position 2q36, encodes another of the ATP-binding cassette transporters.4 ABCB6 functions in heme synthesis with the ATP-dependent uptake of heme and porphyrins into mitochondria.

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13
Q

what BGS is a GPI-linked complement-regulatory glycoprotein also known as the membrane inhibitor of lysis (MIRL).

a. CD59
b. GIL
c. SDa
d. JR

A

ISBT 035 CD59

✓ CD59 is a GPI-linked complement-regulatory glycoprotein also known as the membrane inhibitor of lysis (MIRL).

✓ CD59 plays a key role in protecting against complement regulated hemolysis by binding to C8 and C9 thus interfering with the formation of the membrane-attach complex (MAC).

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14
Q

_____ plays a key role in protecting against complement regulated hemolysis by binding to C8 and C9 thus interfering with the formation of the membrane-attach complex (MAC).

a. CD59
b. GIL
c. SDa
d. JR

A

ISBT 035 CD59

✓ CD59 is a GPI-linked complement-regulatory glycoprotein also known as the membrane inhibitor of lysis (MIRL).

✓ CD59 plays a key role in protecting against complement regulated hemolysis by binding to C8 and C9 thus interfering with the formation of the membrane-attach complex (MAC).

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15
Q

_____________is an acquired hemolytic anemia caused by a mutation in the GPI-linker gene.

a. PNH
b. PCH
c. Hodgkin’s lymphoma
d. aota

A

ISBT 035 CD59

✓ CD59 is a GPI-linked complement-regulatory glycoprotein also known as the membrane inhibitor of lysis (MIRL).

✓ CD59 plays a key role in protecting against complement regulated hemolysis by binding to C8 and C9 thus interfering with the formation of the membrane-attach complex (MAC).

✓ Paroxysmal nocturnal hemoglobinuria (PNH) is an acquired hemolytic anemia caused by a mutation in the GPI-linker gene. PNH patients are deficient in all GPI-linked proteins, including CD59.

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16
Q

Associated with Hodgkin’s lymphoma, and metastasis in renal carcinoma

a. CD59
b. LUKE Antigen
c. SDa
d. JR

A

LUKE(LKE) Antigen
✓ Associated with Hodgkin’s lymphoma, and metastasis in renal carcinoma

✓ Decreased expression of the LKE is seen in individuals with the Se gene with secretors having a 3- to 4-fold decreased risk of E.coli infections

17
Q

✓ Decreased expression of the LKE is seen in individuals with the Se gene with secretors having a 3- to 4-fold decreased risk of ___________

a. Hodgkin’s lymphoma
b, PCH
c. Plasmodium falciparum
d. E.coli

A

LUKE(LKE) Antigen
✓ Associated with Hodgkin’s lymphoma, and metastasis in renal carcinoma

✓ Decreased expression of the LKE is seen in individuals with the Se gene with secretors having a 3- to 4-fold decreased risk of E.coli infections

18
Q

the soluble form of SDA

a. Tamm horsfall glycoprotein
b. uromodulin
c. E.coli
d. PCH

A

The soluble form of Sda is Tamm- Horsfall glycoprotein found in urine. The antigen is not expressed on RBCs of newborns but is in their saliva, urine, and meconium