Lewis, P and MNS bgs Flashcards

1
Q

it is a type 1 glycosphingolipids that are passively absorbed on the RBC membrane plasma

a. ABO
b. Rh
c. Lewis
d. P

A

Unique because Lewis antigens are not intrinsic to RBCs but are type 1 glycosphingolipids that are passively absorbed on the RBC membrane plasma

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2
Q

Lewis gene is code for the production of ______

a. L-fucose
b. fucosyltransferase
c. glycospingolipids
d. n-acetyl-d galactosine

A

Lewis gene (Le, FUT3) codes for the production of FUCOSYLTRANSFERASE enzyme

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3
Q

which of the following lewis phenotypes is non secretor

a. Le (a-b-)
b. Le (a+b-)
c. Le (a+b+)
d. Le(a-b+)

A

Le (a+b-)
- ABH non secretor

Le (a-b+)
- ABH secretor

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4
Q

which of the following phenotype is most frequent in asians

a. Le (a-b-)
b. Le (a+b-)
c. Le (a+b+)
d. Le(a-b+)

A
The Le(a–b–) phenotype
  -   is found more frequently among AFRICANS
The Le(a+b+) phenotype 
   -    is rare among whites and Africans but is more frequent among ASIANS
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5
Q

lewis antibodies is neutralized by

a. enzymes
b. plasma
c. acetic acid

A

Lewis Antibodies

- Easily neutralized by plasma

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6
Q

this BGS is synthesized by sequential action of glycosyltransferases

a. ABO
b. RH
c. P
d. AO`

A

The P blood group antigens, like the ABH antigens, are synthesized by sequential action of glycosyltransferases, which add sugars to precursor substances

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7
Q

which of the following phenotype is a marker of apoptosis

a. P1 antigen
b. Anti - P
c. anti - p1
d. Pk

A
Pk
✓ The Pk antigen is a MARKER OF APOPSOSIS in 
  - GERMINAL CENTER B CELLS
  -  BURKITTS LYMPHOMA
  -LYMPHOBLASTICL EUKEMIA
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8
Q

which of the following phenotype is found in IgG autoantibody in patient with PCH

a. P1 antigen
b. Anti - P
c. anti - p1
d. Pk

A

anti - P

  • naturally occurring individuals
  • Auto Anti-P specificity is found as an IgG autoantibody in patient with Paroxysmal cold hemoglobinuria
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9
Q

which of the following phenotype observed in individuals infected with Echinococcus granulosus

a. P1 antigen
b. Anti - P
c. anti - p1
d. Pk

A

Anti - P1
- IgM antibody

  • Strong anti-P1 was observed in individuals infected with Echinoccocus granulosus
  • Strong antibodies to P1 have also been found in patients with FASCIOLIASIS (bovine liver fluke disease) and in bird handlers
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10
Q

which of the following phenotype reacts over a wide thermal range

a. P1 antigen
b. Anti - P
c. anti - p1
d. Anti PP1Pk

A

Anti- PP1Pk
- originally called Anti - Tja

  • Produced by p individuals early in life without RBC sensitization

✓ Reacts over a wide thermal range (both IgM and IgG)

✓ Associated with SPONTANEOUS ABORTION in early pregnancy

✓ Has potential to cause SEVERE HTRs and HDFN.

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11
Q

which of the following phenotype is associatediwth billiar cirrhosis

a. P1 antigen
b. Anti - Pk
c. anti - p1
d. Anti PP1Pk

A

anti Pk

  • associated with BILLIARY CIRRHOSIS
    AND AUTOIMMUNE HEMOLYTIC ANEMIA
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12
Q

seen in renal patient, who are dialyzed on equipment sterilized with formaldehyde

a. MN antigen
b. S and s antigen
c. Anti - N
d. Anti-Nf

A

Anti-Nf - seen in renal patient, who are dialyzed on equipment sterilized with formaldehyde

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13
Q

which of the following MNS bgs reacts with red cell exposed to glucose solution

a. MN antigen
b. Anti - M
c. Anti - N
d. Anti-Nf

A

Anti - M
✓ May be IgG and IgM

✓ Most examples are cold reactive saline agglutinins

✓ Usually do not bind complement

✓ Do not react with enzyme treated cell

✓ pH-dependent, reacting best at pH 6.5

✓ Others react with red cell exposed to glucose solution

✓ Rarely cause HDN

✓ Shows dosage effect

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14
Q

which of the following MNS bgs is implicated with severe HTR, Hemoglobinuria and HDN

a. Anti S and anti -s
b. Anti - M
c. Anti - N
d. Anti-Nf

A

Anti- S and Anti-s

✓ Most examples are IgG, reactive at 37’C at the antiglobulin test phase

✓ Implicated with severe hemolytic transfusion reaction, hemoglobinuria, and HDN

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15
Q

which of the following MNS bgs can be formed in S-s individuals

a. Anti U
b. Anti - M
c. Anti - N
d. Anti-Nf

A
Anti- U
✓ U- universal
✓ Rare but can be formed in S-s- individuals, found on black people
✓ Can also cause HDN
✓ Enhanced by Enzyme treatment
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16
Q

which of the following MNS bgs is M- N-

a. Mk phenotype
b. . Anti -U
c. En(a-)
d. Anti-Nf

A

En(a-) phenotype
✓ They are M-N-
✓ Confer resistance to Plasmodium falciparum merozoite