minor bgs Flashcards

1
Q

Wra

a. diego
b. cartwright
c. XG
d. Scianna

A

ISBT 010 DIEGO
Antigens: Dia /Dib and Wra Wrb , Wda, Rba, WARR

  • Dia useful tool in ANTHROPOLOGIC MONGOLIAN ANCESTRY
  • located : AE 1 (anion exchange molecule)
  • associated : HEREDITARY SPHEROCYTOSIS. ACANTHOSIS , OVALOCYTOSIS
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2
Q

Antibodies: Both ______________are IgG antibodies reactive in IAT and are considered to be clinically important

A. Wra and Wrb

b. anti - Yta and Ytb
c. Anti-Xga
d. Sc2

A

Antibodies: Both anti-Yta and Anti-Ytb are IgG antibodies reactive in IAT and are considered to be clinically important

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3
Q

Yt antigens have been located on ____________

a. anion exchnge molecule
b. acetylcholinesterase
c. short arm chromosome X
d. chromosome 1 at 1p34

A

Yt antigens have been located on erythrocyte acetylcholinesterase,, which is an enzyme involved in NEUROTRANSMISSION

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4
Q

CARRIED PROTEIN WITH CELL ADHESION THAT HAS BEEN DEMONSTRATED TO HAVE A HOMOLOGY WITH cd 99 MOLECULE

A. diego
b. cartwright
c. XG
d, Scianna

A

ISBT 012 XG
Antigen: Xga
✓ Gene that encodes for the Xg allele is located on the short arm of the X chromosome

✓ Xga antigen is carried by a protein with cell adhesion properties that has been demonstrated to have homology with the CD 99 molecule

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5
Q

what is the protein product of Scianna

a. erythrocyte acethylcholinesterase
b. anion exchange molecule
c. erythroid membraneassociated protein
d. Xg a antigen

A

ISBT 013 SCIANNA
Antigens: Sc1, Sc2 and Sc3 antigens

✓ The very rare Sc:–1,–2,–3 phenotype is the Scianna null type.

✓ The SC gene is located on chromosome 1 at 1p34. The product of the gene is a protein called erythroid membraneassociated protein (ERMAP), which is an RBC adhesion protein.

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6
Q

which of the following bgs is located at chromosome 1 at 1p34

A. diego
b. cartwright
c. XG
d, Scianna

A

ISBT 013 SCIANNA
Antigens: Sc1, Sc2 and Sc3 antigens

✓ The very rare Sc:–1,–2,–3 phenotype is the Scianna null type.

✓ The SC gene is located on chromosome 1 at 1p34. The product of the gene is a protein called erythroid membrane associated protein (ERMAP), which is an RBC adhesion protein.

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7
Q

which BGS does antigen Joseph belongs

a. scianna
b. cromer
c. dombrock
d. colton

A

ISBT 014 DOMBROCK

Antigens: Doa , Dob , Gregory (Gya) , Holley (Hy) , Joseph (Joa)

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8
Q

Anti-Doa and Anti-Dob are described as IgG, red cell-stimulated antibodies that react primarilty in IAT with _______________ or enzyme enhancement - not associated with HDN, but reported to cause delayed transfusion reactions

a. erythroid membrane associated protein (ERMAP
b. polyethylene glycol (PEG)
c. erythrocyte acetylcholinesterase\
d. aota

A

ISBT 014 DOMBROCK

Antigens: Doa , Dob , Gregory (Gya) , Holley (Hy) , Joseph (Joa)

Antibodies:
✓ Anti-Doa and Anti-Dob are described as IgG, red cell-stimulated antibodies that react primarilty in IAT with polyethylene glycol (PEG) or enzyme enhancement - not associated with HDN, but reported to cause delayed transfusion reactions

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9
Q

what bgs is located on the transport protein known as channel forming integral protein (CHIP)

a. dombrock
b. colton
c. chido/rodgers
d. gerbrich

A

ISBT 015 COLTON
Antigen: Coa , Cob , Co3(formerly Coab
)
✓ CO antigens have been located on the transport protein known as channel forming integral protein (CHIP) , which FORMS PRIMARY RBC WATER CHANNEL and is RESPONSIBLE FOR WATER PERMEABILITY

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10
Q

which of the bgs is responsible for water permeability

a. dombrock
b. colton
c. chido/rodgers
d. gerbrich

A

ISBT 015 COLTON
Antigen: Coa , Cob , Co3(formerly Coab
)
✓ CO antigens have been located on the transport protein known as channel forming integral protein (CHIP) , which FORMS PRIMARY RBC WATER CHANNEL and is RESPONSIBLE FOR WATER PERMEABILITY

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11
Q

which of the following colton antibodies is associated with severe HDN

a. anti- Coa
b. anti- Cob
c. anti - Co3

A

✓ Both anti-Coa and Anti-Cob are IgG, red cell stimulated and reactive in IAT, and associated with DHTR

✓ Anti-Co3 is characterized as IgG, red cell stimulated, complement binding, and reacting in the IAT, and associated with severe HDN

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12
Q

which of the following colton antibodies is associated with delayed hemolytic anemia

a. anti- Coa
b. anti- Cob
c. anti - Co3

A

✓ Both anti-Coa and Anti-Cob are IgG, red cell stimulated and reactive in IAT, and associated with DHTR

✓ Anti-Co3 is characterized as IgG, red cell stimulated, complement binding, and reacting in the IAT, and associated with severe HDN

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13
Q

associated with HTA system

a. dombrock
b. colton
c. chido/rodgers
d. gerbrich

A

ISBT 017 CHIDO/RODGERS
Antigens: 6 Ch antigens, 2 Rodgers antigen, WH antigen

✓ Postulated that CH/RG antigens were associated with HLA system

✓ Alleles for RG and CH have been located on two closely linked genes known as C4A and C4B on ch#6

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14
Q

which of the BGS has chracteristics of nebolous

a. dombrock
b. colton
c. chido/rodgers
d. gerbrich

A

ISBT 017 CHIDO/RODGERS
Antigens: 6 Ch antigens, 2 Rodgers antigen, WH antigen

✓ Postulated that CH/RG antigens were associated with HLA system

✓ Alleles for RG and CH have been located on two closely linked genes known as C4A and C4B on ch#6

✓ Serologically, they were both characterized as NEBOLOUS because antigen strength on different samples of RBCs was variable

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15
Q

Ge antigens are inherited oN _________ and are expressed on glycophorins C and/or Glycophorin D

a. Chromosome 1
b. AE1
c. chromosome x
d. chromosome 2

A

Ge antigens are inherited on chromosome 2 and are expressed on glycophorins C and/or Glycophorin D

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16
Q

Individuals of the leach phenotype (GE: -2, -3, -4) present with a change in RBC morphology in the form of _______

a. stomatocytes
b. ovalocytes
c. elliptocytes
d. spherocytes

A

Diego
- Associated with hereditary spherocytosis, Acanthocytosis, and southeast asian ovalocytosis

gerbich
- Individuals of the leach phenotype (GE: -2, -3, -4) present with a change in RBC morphology in the form of ELLIPTOCYTES

17
Q

Anti- CROM antibodies are described as predominantly ______ red cell stimulated, and reactive in IAT

a. IgG1
b. IgG2
c. IgM1
d. Igm2

A

Anti- CROM antibodies are described as predominantly IgG1, red cell stimulated, and reactive in IAT