I and Duffy bgs Flashcards

1
Q

what phenotype of I is Common antibody that can be benign or pathologic

a. Anti -i
b. Anti - I
c. autoanti -I
d. anti-It

A

Anti-I
✓ Common antibody that can be BENIGN OR PATHOLOGIC

✓ Demonstrates STRONG REACTION IN ADULT CELLS and weak reactions with cord cells

✓ Not associated with HDN

✓ Incubating tests in the COLD enhances anti-I reactivity and helps confirm its identity; ALBUMIN AND ENZYME methods also enhance anti-I reactivity

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2
Q

What phenotype of I is Potent IgM agglutinins with higher titers and broader thermal range of activity, reacting up to 30° or 32°C

a. Anti -i
b. Anti - I
c. autoanti -I
d. anti-It

A

Pathologic Anti - I or Autoanti -I
- Potent IgM agglutinins with higher titers and broader thermal range of activity, reacting up to 30° or 32°C

  • attach to vivo and cause AUTOAGGLUTINATION, VASCULAR OBSTRUCTION (RAYNAUD’S PHENOMENON) , AND INTRAVASCULAR HEMOLYSIS
  • MYCOPLASMA PNEUMONIAE
  • Listeria monocytogenes organism from a patient with COLD AUTOIMMUNE HEMOLYTIC ANMEIA has been reported to ABSORB anti - I
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3
Q

which of the I phenotype is associated with HDN

a. Anti -i
b. Anti - I
c. autoanti -I
d. anti-It

A

Anti - i

  • most autoanti- i is IgM
  • IgG anti - i also been described and has been associated with HDN
  • infectious mononucleosis, alcoholic cirrhosis, myeloid leukemia and reticuloses
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4
Q

which of the following I phenotype is common in melanesians

a. Anti -i
b. Anti - I
c. autoanti -I
d. anti-It

A

Anti-IT

✓ Naturally occurring antibody among MELANESIANS, COASTAL RESIDENTS OF PAPUA NEW GUINEA, YAYOMA AND VENEZUELA

✓ Examples of IgM and IgG anti-IT reacting preferentially at 37°C have also been found in patients with WARM AUTOIMMUNE HEMOLYTIC ANEMIA AND HODGKIN’S LYMPHOMA

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5
Q

Anti - I is associated with

a. infectious mononucleosis
b. cold agglutinin disease
c. M. pneumoniae
d. aota

A

Auto - I
associated with COLD AGGLUTININ DISEASE AND MYCOPLASMA PNEUMONIAE

Auto - i
- associated with INFECTIOUS MONONUCLEOSIS

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6
Q

in asians the adult that has i phenotype has been associated with

a. PNH
b. congenital cataracts
c. chronic hemolytic anemia
d. HEMPAS

A

❖ Chronic dyserythropoietic anemia type II or hereditary erythroblastic multinuclearity with a positive acidified serum test (HEMPAS) is associated with much greater i activity

❖ In Asians, the i adult phenotype has been associated with congenital cataracts

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7
Q

what is the two common antigen of Duffy

a. Fya
b. Fyb
c. Fyx
d. Fy6

A

Fya and Fyb

- two most common Duffy Ag

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8
Q

An inherited weak form of Fyb that reacts with some examples of anti-Fyb

a. Fyx
b. Fy6
c. Fy3
d. Fy5

A

Fyx

An inherited WEAK FORM of Fyb that reacts with some examples of anti-Fyb

Fy6

Is an important for invasion for P.vivax and P.knowlesi

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9
Q

Is an important for invasion for P.vivax

a. Fyx
b. Fy6
c. Fy3
d. Fy5

A

Fyx

An inherited WEAK FORM of Fyb that reacts with some examples of anti-Fyb

Fy6

Is an important for invasion for P.vivax and P.knowlesi

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10
Q

Duffy phenotype have been associated with ACUTE AND DELAYED HTRs

a. Anti - Fya
b. Anti - Fyb
c. Fy3
d. Fy5

A

Anti Fya and Anti Fyb

  • IgG
  • reacts at antiglobulin phase
  • activity enhance at LOW IONIC STRENGTH SOLUTION
  • associated with ACUTE AND DELAYED HTRs
  • SHOW DOSAGE EFFECT
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11
Q

Duffy phenotype has been found in serum of Fy (a- b-)

a. Anti - Fya
b. Anti - Fyb
c. Fy3
d. Fy5

A

Fy3 antigen and Anti –fy3

✓ Found in the serum of an Fy(a–b–)

✓ Unlike Fya and Fyb, the Fy3 antigen is not destroyed by enzymes.

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12
Q

it is thought to be like Fy3ecause it reacted with all fy (a+) or Fy (b+) but not with Fy (a-b-)

a. Anti - Fya
b. Anti - Fyb
c. Fy6
d. Fy5

A

Fy5 antigen and antibody

Initially it was thought to be a second example of anti-Fy3, because it reacted with all Fy(a+) or Fy(b+) RBCs but not with Fy(a–b–) cells.

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13
Q

which of the following duffy phenotype is common in chinese

a. Fy (a+b-)
b. Fy (a-b-)
c. Fy (a-b+)
d. Fy (a+b+)

A

Fy (a+b-)
- common in Chinese

Fy (a-b-)
- american balcks

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14
Q

resist infection in vitro by the monkey malaria organism Plasmodium knowlesi and Plasmodium vivax

a. Fy (a+b-)
b. Fy (a-b-)
c. Fy (a-b+)
d. Fy6

A

Fy(a-b-)

  • resist infection in vitro by the monkey malaria organism Plasmodium knowlesi and Plasmodium vivax
  • has been linked to lower neutrophil counts, susceptibility to infection, renal disease, and reduced graft survival following renal transplantation
  • Commonly found in black population
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