I and Duffy bgs Flashcards
what phenotype of I is Common antibody that can be benign or pathologic
a. Anti -i
b. Anti - I
c. autoanti -I
d. anti-It
Anti-I
✓ Common antibody that can be BENIGN OR PATHOLOGIC
✓ Demonstrates STRONG REACTION IN ADULT CELLS and weak reactions with cord cells
✓ Not associated with HDN
✓ Incubating tests in the COLD enhances anti-I reactivity and helps confirm its identity; ALBUMIN AND ENZYME methods also enhance anti-I reactivity
What phenotype of I is Potent IgM agglutinins with higher titers and broader thermal range of activity, reacting up to 30° or 32°C
a. Anti -i
b. Anti - I
c. autoanti -I
d. anti-It
Pathologic Anti - I or Autoanti -I
- Potent IgM agglutinins with higher titers and broader thermal range of activity, reacting up to 30° or 32°C
- attach to vivo and cause AUTOAGGLUTINATION, VASCULAR OBSTRUCTION (RAYNAUD’S PHENOMENON) , AND INTRAVASCULAR HEMOLYSIS
- MYCOPLASMA PNEUMONIAE
- Listeria monocytogenes organism from a patient with COLD AUTOIMMUNE HEMOLYTIC ANMEIA has been reported to ABSORB anti - I
which of the I phenotype is associated with HDN
a. Anti -i
b. Anti - I
c. autoanti -I
d. anti-It
Anti - i
- most autoanti- i is IgM
- IgG anti - i also been described and has been associated with HDN
- infectious mononucleosis, alcoholic cirrhosis, myeloid leukemia and reticuloses
which of the following I phenotype is common in melanesians
a. Anti -i
b. Anti - I
c. autoanti -I
d. anti-It
Anti-IT
✓ Naturally occurring antibody among MELANESIANS, COASTAL RESIDENTS OF PAPUA NEW GUINEA, YAYOMA AND VENEZUELA
✓ Examples of IgM and IgG anti-IT reacting preferentially at 37°C have also been found in patients with WARM AUTOIMMUNE HEMOLYTIC ANEMIA AND HODGKIN’S LYMPHOMA
Anti - I is associated with
a. infectious mononucleosis
b. cold agglutinin disease
c. M. pneumoniae
d. aota
Auto - I
associated with COLD AGGLUTININ DISEASE AND MYCOPLASMA PNEUMONIAE
Auto - i
- associated with INFECTIOUS MONONUCLEOSIS
in asians the adult that has i phenotype has been associated with
a. PNH
b. congenital cataracts
c. chronic hemolytic anemia
d. HEMPAS
❖ Chronic dyserythropoietic anemia type II or hereditary erythroblastic multinuclearity with a positive acidified serum test (HEMPAS) is associated with much greater i activity
❖ In Asians, the i adult phenotype has been associated with congenital cataracts
what is the two common antigen of Duffy
a. Fya
b. Fyb
c. Fyx
d. Fy6
Fya and Fyb
- two most common Duffy Ag
An inherited weak form of Fyb that reacts with some examples of anti-Fyb
a. Fyx
b. Fy6
c. Fy3
d. Fy5
Fyx
An inherited WEAK FORM of Fyb that reacts with some examples of anti-Fyb
Fy6
Is an important for invasion for P.vivax and P.knowlesi
Is an important for invasion for P.vivax
a. Fyx
b. Fy6
c. Fy3
d. Fy5
Fyx
An inherited WEAK FORM of Fyb that reacts with some examples of anti-Fyb
Fy6
Is an important for invasion for P.vivax and P.knowlesi
Duffy phenotype have been associated with ACUTE AND DELAYED HTRs
a. Anti - Fya
b. Anti - Fyb
c. Fy3
d. Fy5
Anti Fya and Anti Fyb
- IgG
- reacts at antiglobulin phase
- activity enhance at LOW IONIC STRENGTH SOLUTION
- associated with ACUTE AND DELAYED HTRs
- SHOW DOSAGE EFFECT
Duffy phenotype has been found in serum of Fy (a- b-)
a. Anti - Fya
b. Anti - Fyb
c. Fy3
d. Fy5
Fy3 antigen and Anti –fy3
✓ Found in the serum of an Fy(a–b–)
✓ Unlike Fya and Fyb, the Fy3 antigen is not destroyed by enzymes.
it is thought to be like Fy3ecause it reacted with all fy (a+) or Fy (b+) but not with Fy (a-b-)
a. Anti - Fya
b. Anti - Fyb
c. Fy6
d. Fy5
Fy5 antigen and antibody
Initially it was thought to be a second example of anti-Fy3, because it reacted with all Fy(a+) or Fy(b+) RBCs but not with Fy(a–b–) cells.
which of the following duffy phenotype is common in chinese
a. Fy (a+b-)
b. Fy (a-b-)
c. Fy (a-b+)
d. Fy (a+b+)
Fy (a+b-)
- common in Chinese
Fy (a-b-)
- american balcks
resist infection in vitro by the monkey malaria organism Plasmodium knowlesi and Plasmodium vivax
a. Fy (a+b-)
b. Fy (a-b-)
c. Fy (a-b+)
d. Fy6
Fy(a-b-)
- resist infection in vitro by the monkey malaria organism Plasmodium knowlesi and Plasmodium vivax
- has been linked to lower neutrophil counts, susceptibility to infection, renal disease, and reduced graft survival following renal transplantation
- Commonly found in black population
