kidd, kell, lutheran BGS Flashcards
how many weeks to detect Jk a
a. 11 weeks
b. 7 weeks
c. 8 weeks
d. 2 weeks
JKa and JKb
- commonly found in RBC of most individuals
- detected on fetal rd cells as early as 11 weeks for JKa
and 7 weeks for JKb - not altered by enzymes
which of the bgs has a notorious reputation in blood bank
a. kidd
b, duffy
c. lutheran
d. P
answer : Kidd
kidd antibodies have a NOTORIOUS REPUTATION IN BLOOD BANK
which of the bgs is most common cause of DHTR
a. kidd
b, duffy
c. lutheran
d. P
answer: kidd
anti JKa and anti JKb
- they are immune antibodies amde to response to PREGANCY OR TRANSFUSION
- The decline in antibody reactivity and the difficulty in detecting Kidd antibodies are reasons why they are a common cause of HTRs, especially of the delayed type
✓ Most Common cause of DHTR (delayed hemolytic transfusion reaction)
✓ Contrary to their hemolytic reputation in transfusion, most Kidd antibodies are only rarely associated with severe cases of HDFN
Ingestion of Methyldopa will lead to Autoab formation directed to what BGS
a. kidd
b, duffy
c. lutheran
d. P
Drug Induced Autoantibody (auto ab kidd)
✓ Associated with KIDD BGS on patient receiving ALDOMET/METHYLDOPA and another was chlorpropamide-dependent
_______resists lysis in 2M urea
a. Jk(a-b-)
b. Jk(a+b-)
c. Fy (a-b-)
d. Fy(a+b-)
Jk(a-b-) resists lysis in 2M urea
Jk(a+b+) LYSED in 2M urea
it was the first blood group system discovered after the introduction of antiglobulin testing.
a. kidd
b, duffy
c. lutheran
d. Kell
Kell
3rd most important BGS
a. kidd
b, Kell
c. lutheran
d. P
1st - ABO
2nd - Rh
3rd - Kell
k antigen can be detected on fetal bc as early as __
a. 11 weeks
b. 6 weeks
c. 10 weeks
d. 5 weeks
The K antigen can be detected on fetal RBCs as early as 10 weeks and is well developed at birth.
The Kell glycoprotein is covalently linked with another protein, called ___,
a. Anti - LW
b. oH
c. XK
d. aota
The Kell glycoprotein is covalently linked with another protein, called Xk, by a single disulfide
bond.
Kell antigen expression is dependent upon the presence of the Xk protein
absence of XK result in _____
a. infectious mononucleosis
b. Mc Leod syndrome
c. Mycoplasma pneumoniae
d. PNH
The absence of Xk results in McLeod syndrome. It is also associated with CGD (Chronic granulomatous disease)
Infectious mononucleosis
- Anti - i
Mycoplasma pneumoniae
- Anti I
Paroxysmal nocurnal hemoglobinuria
-antii - i
Kpb
a. penny
b. rautenberg
c. cellano
d. matthews
-K (Kell), k (Cellano), Kpa(Penny), Kpb(Rautenberg), Jsa(Sutter), Jsb(Matthews)
depressed Kell antigen are seen on RBCs witth rare
a. hodgkins lymphoma
b. leach phenotype
c. CGD
d. Mc leod syndrome
- Depressed Kell antigens are seen on RBCs with the rare Gerbich-negative phenotypes Ge: –2, –3, 4 and Ge: –2, –3, –4.(leach phenotype)
- Patients with AUTPIMMUNE HEMOLYTIC ANEMIA, in which the autoantibody is directed against a Kell antigen, may have depressed expression of that antigen.
most common antibody can be seen in bloodbank
a. anti JK
b. alloanti - JK3
c. anti- K
d. anti Fya
anti-K is the most common antibody seen in the blood bank
anti - K can seen in serum of what individual
a. KK
b. kk
c. Kk
d nota
b.kk
what BGS is 2nd to D in terms of immunogenicity
a. kidd
b. duffy
c. kell
d. lutheran
excluding ABO, K is rated as SECOND ONLY TO D IN TERMSOF IMMUNOGENICITY
LACK OF EXPRESSION OF KELL ANTIGENS
A. Kx antigen
b. Ko phenotype
c. Anti - Ku
Ko phenotype
- Ko RBCs LACK OF EXPRESSION of all Kell antigens
which of the following is low frequency Kell antigens
a. Kpa
b. k
c. Jsa
d. Jsb
Antibodies to Kpa ,Jsa ,and other low frequency Kell antigens
- exposed to the antigen
- Most often detected through unexpected incompatible cross-matches or cases of HDN
Antibodies to k, Kpb , Jsb ,and other High frequency Kell antigen
- Antibodies to high frequency Kell antigens are rare, because so few people lack the antigen
what BGS does blood bankers seldom deal
a. kidd
b. kell
c. duffy
d. lutheran
Lutheran BGS
- Blood bankers seldom deal with the serology of the Lutheran blood group system.
HDFN is rare and only mild at birth
a. Lutheran
b. MNS
c. Kell
d. Duffy
answer: Lutheran BGS
Lua and Lub
- HDFN is rare and only mild at birth
- Lutheran glycoprotein on placental tissue may result in adsorption of maternal antibodies to Lutheran antigens, thus decreasing the likelihood of HDFN
whichof the antibody of Lutheran is IgG
a. Anti - Lua
b. Anti Lub
c. Anti Lu3
d. nota
Anti-Lua
✓ Most are naturally occurring saline agglutinins (IgM) that react better at room temperature than 37’C
✓ Experienced technologists recognize Lutheran antibodies by their characteristic loose, mixed-field reactivity in a test tube
which of the bgs has a chaacteristics is losse, mixed ield reactivity on test tube
a. Anti - Lua
b. Anti Lub
c. Anti Lu3
d. nota
Anti-Lua
✓ Most are naturally occurring saline agglutinins (IgM) that react better at room temperature than 37’C
✓ Experienced technologists recognize Lutheran antibodies by their characteristic loose, mixed-field reactivity in a test tube
Implicated with shortened survival of transfused cells and post transfusion jaundice
a. Anti - Lua
b. Anti Lub
c. Anti Lu3
d. nota
Anti-Lub
- Most are IgG although IgM and IgA antibodies have been noted
- Implicated with shortened survival of transfused cells and post transfusion jaundice
