Transdermal Delivery Flashcards
1
Q
Do they avoid first-pass effect?
A
Yes
2
Q
What are some advantages of transdermal patches?
A
- Lack of peaks in plasma (minimizes AE)
- Used for drugs w/ narrow therapeutic window
- Delivers steady infusion of RX
- Improved pt compliance
3
Q
What are some disadvantages of transdermal patches?
A
- Cant deliver ionic RX
- Cannot use large molecules (>500)
- Cannot be used for RX requiring high blood levels
- Expensive
4
Q
What were the rodent models for in vivo testing?
A
“Skinless?” mouse/rat
5
Q
What were the non human primate models for in vivo testing?
A
Weanling pig, rhesus monkey
6
Q
An ophthalmic suspension w/ suitable particle size would be…
A
<10micrometers
7
Q
The major routes of skin permeations occur via…
Transcellular
Paracellular
Transfollicular
A
Transcellular
Paracellular
8
Q
What layer of the cornea is the major limiting barrier for hydrophilic RX?
A
Corneal epithelium
