Brainscape's Knowledge GenomeTM


Top Flashcards (Certified)
All Flashcards

Pharmaceutics > Buccal and Sublingual Drug Delivery > Flashcards

Buccal and Sublingual Drug Delivery Flashcards

1
Q

Sublingual vs Buccal

Which is more permeable?

A

Sublingual

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

Sublingual vs Buccal

Which has rapid onset/bioavailability?

A

Sublingual

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

Sublingual vs Buccal

Which can provide sustained delivery?

A

Buccal

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

Sublingual vs Buccal

Which one does not provide good bioavailability?

A

Buccal

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

Sublingual vs Buccal

Which one has systemic delivery?

A

Both

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

Sublingual vs Buccal

Which one has local delivery?

A

Buccal

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

What are the three layers of the oral mucosa?

A
  1. Epithelial membrane
  2. Basement membrane
  3. Lamina propria
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

What is the function of the epithelial membrane?

A

Protection

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

Of the layers of the oral mucosa, which one is the innermost layer?

A

Basement membrane

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

Of the layers of the oral mucosa, which one is also known as the submucosa?

A

Lamina Propria

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

Describe the cell size of the epithelial membrane of the oral mucosa

A

Cell size increases + flattens as it goes from basal to superficial

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

Sublingual vs Buccal

Which has a thinner membrane?

A

Sublingual

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

What is special about the basal layer of the epithelial membrane of the oral mucosa?

A

Basal cell layer is mitotically active

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

What is the purpose of the basement layer of the epithelial membrane?

A

New cell production

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

What is the purpose of the Lamina Propria of the epithelial membrane?

A

Contains rich supply of blood vessels

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

What is the function of saliva?

A
  1. Protective film

2. Acts as an anti-adherent

17
Q

What is found in saliva?

A

Mostly water

But also salts, proteins, and amylase

18
Q

How much saliva is produced per day? When is more produced? Less?

A

1L per day following a circadian rhythm

Heavily reduced when sleeping
Reduced in morning
Increased in afternoon
Increase when stimulated

19
Q

For systemic delivery, what is the main drug transport pathway?

A

Paracellular

20
Q

What is a permeability enhancer?

A

A chemical that REVERISBILY reduces the resistance of the barrier to drug penetration without permanently damaging any viable cells

21
Q

What are some common permeability enhancer groups?

A
  1. FA
  2. Bile salts
  3. Surfactants
22
Q

What does CO2 do with permeability?

A

Increases it

EX: effervescent fentanyl tabs

23
Q

What kind of bonds do mucoadhesions form?

A

Secondary non-covalent bonds

24
Q

What kind of mucoadhesion materials should be found?

A
  1. Hydrophilic

2. Lots of hydroxyl, carboxyl, and amine groups

25
Q

What kind of bonds form weaker adhesives?

26
Q

What are the two kinds of FDA approved adhesives?

A

Cationic + Anionic

Pharmaceutics (30 decks)

Brainscape helps you reach your goals faster, through stronger study habits.
© 2025 Bold Learning Solutions. Terms and Conditions